Literature DB >> 6246273

BK virus DNA sequence coding for the t and T antigens and evaluation of methods for determining sequence homology.

R C Yang, A Young, R Wu.   

Abstract

The DNA sequence of the early region of the human papovavirus BK (MM strain) was determined. A potential initiation signal for translation is located at nucleotides 3,047 to 3,045 or map position 0.614. Extending counterclockwise from this AUG signal there is only one open reading frame, which can code for a putative t antigen of 100 amino acids in length. If the early mRNA of BKV is spliced, then the regions between nucleotides 3,047 to 2,808 and 2,725 to 884 can code for a T antigen 694 amino acids in length. The sequences of the deduced T antigens in BK virus share 71% amino acid homology with those in simian virus 40, whereas the coding sequences of the two viruses share 70% DNA homology. Comparison of DNA sequences and evaluation of homology measurements between these two viruses are discussed.

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Year:  1980        PMID： 6246273      PMCID： PMC288720     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  51 in total

1.  Nucleotide sequence analysis of DNA. IV. Complete nucleotide sequence of the left-hand cohesive end of coliphage 186 DNA.

Authors:  R Padmanabhan; R Wu
Journal:  J Mol Biol       Date:  1972-04-14       Impact factor: 5.469

2.  New human papovavirus (B.K.) isolated from urine after renal transplantation.

Authors:  S D Gardner; A M Field; D V Coleman; B Hulme
Journal:  Lancet       Date:  1971-06-19       Impact factor: 79.321

3.  Selective extraction of polyoma DNA from infected mouse cell cultures.

Authors:  B Hirt
Journal:  J Mol Biol       Date:  1967-06-14       Impact factor: 5.469

4.  Improved estimation of secondary structure in ribonucleic acids.

Authors:  I Tinoco; P N Borer; B Dengler; M D Levin; O C Uhlenbeck; D M Crothers; J Bralla
Journal:  Nat New Biol       Date:  1973-11-14

5.  Nucleotide sequence analysis of DNA. II. Complete nucleotide sequence of the cohesive ends of bacteriophage lambda DNA.

Authors:  R Wu; E Taylor
Journal:  J Mol Biol       Date:  1971-05-14       Impact factor: 5.469

6.  Isolation of papovavirus from brain tumor and urine of a patient with Wiskott-Aldrich syndrome.

Authors:  K K Takemoto; A S Rabson; M F Mullarkey; R M Blaese; C F Garon; D Nelson
Journal:  J Natl Cancer Inst       Date:  1974-11       Impact factor: 13.506

7.  Thermodynamic and kinetic studies on the interconversion between the linear and circular forms of phage lambda DNA.

Authors:  J C Wang; N Davidson
Journal:  J Mol Biol       Date:  1966-01       Impact factor: 5.469

8.  Cyclization of coliphage 186 DNA.

Authors:  J C Wang
Journal:  J Mol Biol       Date:  1967-09-28       Impact factor: 5.469

9.  Human papovavirus, BK strain: biological studies including antigenic relationship to simian virus 40.

Authors:  K K Takemoto; M F Mullarkey
Journal:  J Virol       Date:  1973-09       Impact factor: 5.103

10.  Malignant transformation of BHK21 clone 13 cells by BK virus--a human papovavirus.

Authors:  E O Major; G Di Mayorca
Journal:  Proc Natl Acad Sci U S A       Date:  1973-11       Impact factor: 11.205
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  2 in total

1.  Structural relationships between the surface antigens of ground squirrel hepatitis virus and human hepatitis B virus.

Authors:  W H Gerlich; M A Feitelson; P L Marion; W S Robinson
Journal:  J Virol       Date:  1980-12       Impact factor: 5.103

2.  Genome-specific repetitive sequences in the genus Oryza.

Authors:  X Zhao; T Wu; Y Xie; R Wu
Journal:  Theor Appl Genet       Date:  1989-08       Impact factor: 5.699
  2 in total

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