Literature DB >> 2026425

Determination of the origin of nondisjunction in a 49,XXXXY male using hypervariable dinucleotide repeat sequences.

T H Huang1, F Greenberg, D H Ledbetter.   

Abstract

We present a patient with a 49,XXXXY chromosome constitution in whom the origin of the extra X chromosomes was determined by analysis of five polymorphic CA (or GT) dinucleotide repeat sequences. This class of DNA marker has recently been demonstrated to be hypervariable with heterozygosity values up to 80%. By polymerase chain reaction (PCR) analysis of the dinucleotide repeat length polymorphisms, we have shown that all four X chromosomes were of maternal origin.

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Year:  1991        PMID： 2026425     DOI： 10.1007/bf00201553

Source DB:  PubMed          Journal:  Hum Genet        ISSN： 0340-6717            Impact factor:   4.132


  9 in total

1.  Origin of the X chromosomes in a patient with the 49,XXXXY syndrome.

Authors:  D S Plaha; D P Duckett; R A Collacott; I D Young
Journal:  J Med Genet       Date:  1990-03       Impact factor: 6.318

2.  Five polymorphic microsatellite VNTRs on the human X chromosome.

Authors:  J A Luty; Z Guo; H F Willard; D H Ledbetter; S Ledbetter; M Litt
Journal:  Am J Hum Genet       Date:  1990-04       Impact factor: 11.025

3.  Parental origin of chromosomal nondisjunction in a 49,XXXXY male using recombinant-DNA techniques.

Authors:  M Villamar; J Benitez; E Fernández; C Ayuso; C Ramos
Journal:  Clin Genet       Date:  1989-09       Impact factor: 4.438

4.  Xg and sex-chromosome abnormalities.

Authors:  R R Race; R Sanger
Journal:  Br Med Bull       Date:  1969-01       Impact factor: 4.291

5.  Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction.

Authors:  J L Weber; P E May
Journal:  Am J Hum Genet       Date:  1989-03       Impact factor: 11.025

6.  A member of a new repeated sequence family which is conserved throughout eucaryotic evolution is found between the human delta and beta globin genes.

Authors:  R Miesfeld; M Krystal; N Arnheim
Journal:  Nucleic Acids Res       Date:  1981-11-25       Impact factor: 16.971

7.  A hypervariable microsatellite revealed by in vitro amplification of a dinucleotide repeat within the cardiac muscle actin gene.

Authors:  M Litt; J A Luty
Journal:  Am J Hum Genet       Date:  1989-03       Impact factor: 11.025

8.  X-chromosome polysomy in the male. The Leuven experience 1966-1987.

Authors:  A Kleczkowska; J P Fryns; H Van den Berghe
Journal:  Hum Genet       Date:  1988-09       Impact factor: 4.132

9.  Informativeness of human (dC-dA)n.(dG-dT)n polymorphisms.

Authors:  J L Weber
Journal:  Genomics       Date:  1990-08       Impact factor: 5.736
  9 in total
  2 in total

1.  Parental origin of the extra chromosomes in polysomy X.

Authors:  C A Leal; J W Belmont; R Nachtman; J M Cantu; C Medina
Journal:  Hum Genet       Date:  1994-10       Impact factor: 4.132

2.  49,XXXXY: a distinct phenotype. Three new cases and review.

Authors:  J Peet; D D Weaver; G H Vance
Journal:  J Med Genet       Date:  1998-05       Impact factor: 6.318
  2 in total

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