Literature DB >> 2024230

A multi-dimensional coalescent process applied to multi-allelic selection models and migration models.

J Hey1.   

Abstract

For a sample of two genes from a population divided into an arbitrary number of allele classes, a general mathematical framework is developed to address the expectation and variance of the time of the most recent common ancestor. Depending on the meaning of allele classes and the manner in which genes can change among them, this framework can be applied to a diversity of population genetic models. By adoption of the infinite sites model, the effect on heterozygosity is modelled for balancing selection among allele classes, mutation between allele classes, migration among populations, and gene conversion between loci. Most results are described for a continuous time approximation to a discrete generation model. It is also shown how the discrete generation model can be used to study the hitch-hiking effect of favorable mutations.

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Year:  1991        PMID: 2024230     DOI: 10.1016/0040-5809(91)90039-i

Source DB:  PubMed          Journal:  Theor Popul Biol        ISSN: 0040-5809            Impact factor:   1.570


  26 in total

Review 1.  Genetic hitchhiking.

Authors:  N H Barton
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2000-11-29       Impact factor: 6.237

Review 2.  Effects of metapopulation processes on measures of genetic diversity.

Authors:  J R Pannell; B Charlesworth
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2000-12-29       Impact factor: 6.237

3.  The coalescent and infinite-site model of a small multigene family.

Authors:  Hideki Innan
Journal:  Genetics       Date:  2003-02       Impact factor: 4.562

4.  The genealogy of sequences containing multiple sites subject to strong selection in a subdivided population.

Authors:  Magnus Nordborg; Hideki Innan
Journal:  Genetics       Date:  2003-03       Impact factor: 4.562

5.  Patterns of neutral diversity under general models of selective sweeps.

Authors:  Graham Coop; Peter Ralph
Journal:  Genetics       Date:  2012-06-19       Impact factor: 4.562

6.  Coalescence with Background and Balancing Selection in Systems with Bi- and Uniparental Reproduction: Contrasting Partial Asexuality and Selfing.

Authors:  Aneil F Agrawal; Matthew Hartfield
Journal:  Genetics       Date:  2015-11-19       Impact factor: 4.562

7.  A separation-of-timescales approach to the coalescent in a continuous population.

Authors:  Jon F Wilkins
Journal:  Genetics       Date:  2004-12       Impact factor: 4.562

8.  Coalescence times and FST under a skewed offspring distribution among individuals in a population.

Authors:  Bjarki Eldon; John Wakeley
Journal:  Genetics       Date:  2008-12-01       Impact factor: 4.562

Review 9.  Fundamental concepts in genetics: effective population size and patterns of molecular evolution and variation.

Authors:  Brian Charlesworth
Journal:  Nat Rev Genet       Date:  2009-03       Impact factor: 53.242

10.  Identifying loci under selection against gene flow in isolation-with-migration models.

Authors:  Vitor C Sousa; Miguel Carneiro; Nuno Ferrand; Jody Hey
Journal:  Genetics       Date:  2013-03-02       Impact factor: 4.562

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