Literature DB >> 20231456

From the Cover: mitotic gene conversion events induced in G1-synchronized yeast cells by gamma rays are similar to spontaneous conversion events.

Phoebe S Lee1, Thomas D Petes.   

Abstract

In a previous study, we mapped spontaneous mitotic reciprocal crossovers (RCOs) in a 120-kb interval of chromosome V of Saccharomyces cerevisiae. About three-quarters of the crossovers were associated with gene conversion tracts. About 40% of these conversion tracts had the pattern expected as a consequence of repair of a double-stranded DNA break (DSB) of an unreplicated chromosome. We test this hypothesis by examining the crossovers and gene conversion events induced by gamma irradiation in G1- and G2-arrested diploid yeast cells. The gene conversion patterns of G1-irradiated cells (but not G2-irradiated cells) mimic conversion events associated with spontaneous RCOs, confirming our previous conclusion that many spontaneous crossovers are initiated by a DSB on an unreplicated chromosome.

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Year:  2010        PMID： 20231456      PMCID： PMC2867710          DOI： 10.1073/pnas.1001940107

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  36 in total

1.  Alteration of gene conversion tract length and associated crossing over during plasmid gap repair in nuclease-deficient strains of Saccharomyces cerevisiae.

Authors:  L S Symington; L E Kang; S Moreau
Journal:  Nucleic Acids Res       Date:  2000-12-01       Impact factor: 16.971

Review 2.  DNA damage and repair following treatment with ionizing radiation.

Authors:  S Powell; T J McMillan
Journal:  Radiother Oncol       Date:  1990-10       Impact factor: 6.280

3.  Somatic Crossing over and Segregation in Drosophila Melanogaster.

Authors:  C Stern
Journal:  Genetics       Date:  1936-11       Impact factor: 4.562

4.  The Saccharomyces cerevisiae Ku autoantigen homologue affects radiosensitivity only in the absence of homologous recombination.

Authors:  W Siede; A A Friedl; I Dianova; F Eckardt-Schupp; E C Friedberg
Journal:  Genetics       Date:  1996-01       Impact factor: 4.562

5.  The relevance of the nuclear division cycle to radiosensitivity in yeast.

Authors:  G Brunborg; D H Williamson
Journal:  Mol Gen Genet       Date:  1978-07-04

Review 6.  Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae.

Authors:  F Pâques; J E Haber
Journal:  Microbiol Mol Biol Rev       Date:  1999-06       Impact factor: 11.056

7.  Cell division transforms mutagenic lesions into deletion-recombinagenic lesions in yeast cells.

Authors:  A Galli; R H Schiestl
Journal:  Mutat Res       Date:  1999-08-11       Impact factor: 2.433

8.  Rad52 forms DNA repair and recombination centers during S phase.

Authors:  M Lisby; R Rothstein; U H Mortensen
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

9.  Role of the Saccharomyces cerevisiae Rad51 paralogs in sister chromatid recombination.

Authors:  Amy M Mozlin; Cindy W Fung; Lorraine S Symington
Journal:  Genetics       Date:  2008-01       Impact factor: 4.562

10.  DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1.

Authors:  Grzegorz Ira; Achille Pellicioli; Alitukiriza Balijja; Xuan Wang; Simona Fiorani; Walter Carotenuto; Giordano Liberi; Debra Bressan; Lihong Wan; Nancy M Hollingsworth; James E Haber; Marco Foiani
Journal:  Nature       Date:  2004-10-21       Impact factor: 49.962
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  33 in total

1.  Initiation and completion of spontaneous mitotic recombination occur in different cell cycle phases.

Authors:  Lorraine S Symington
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-23       Impact factor: 11.205

2.  Mus81 and Yen1 promote reciprocal exchange during mitotic recombination to maintain genome integrity in budding yeast.

Authors:  Chu Kwen Ho; Gerard Mazón; Alicia F Lam; Lorraine S Symington
Journal:  Mol Cell       Date:  2010-12-22       Impact factor: 17.970

3.  Interhomolog recombination and loss of heterozygosity in wild-type and Bloom syndrome helicase (BLM)-deficient mammalian cells.

Authors:  Jeannine R LaRocque; Jeremy M Stark; Jin Oh; Ekaterina Bojilova; Kosuke Yusa; Kyoji Horie; Junji Takeda; Maria Jasin
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-05       Impact factor: 11.205

4.  The Transient Inactivation of the Master Cell Cycle Phosphatase Cdc14 Causes Genomic Instability in Diploid Cells of Saccharomyces cerevisiae.

Authors:  Oliver Quevedo; Cristina Ramos-Pérez; Thomas D Petes; Félix Machín
Journal:  Genetics       Date:  2015-05-12       Impact factor: 4.562

5.  Understanding the origins of UV-induced recombination through manipulation of sister chromatid cohesion.

Authors:  Shay Covo; Wenjian Ma; James W Westmoreland; Dmitry A Gordenin; Michael A Resnick
Journal:  Cell Cycle       Date:  2012-09-17       Impact factor: 4.534

6.  The baker's yeast diploid genome is remarkably stable in vegetative growth and meiosis.

Authors:  K T Nishant; Wu Wei; Eugenio Mancera; Juan Lucas Argueso; Andreas Schlattl; Nicolas Delhomme; Xin Ma; Carlos D Bustamante; Jan O Korbel; Zhenglong Gu; Lars M Steinmetz; Eric Alani
Journal:  PLoS Genet       Date:  2010-09-09       Impact factor: 5.917

7.  Competitive repair by naturally dispersed repetitive DNA during non-allelic homologous recombination.

Authors:  Margaret L Hoang; Frederick J Tan; David C Lai; Sue E Celniker; Roger A Hoskins; Maitreya J Dunham; Yixian Zheng; Douglas Koshland
Journal:  PLoS Genet       Date:  2010-12-02       Impact factor: 5.917

8.  SUMOylation of Rad52-Rad59 synergistically change the outcome of mitotic recombination.

Authors:  Sonia Silva; Veronika Altmannova; Nadine Eckert-Boulet; Peter Kolesar; Irene Gallina; Lisa Hang; Inn Chung; Milica Arneric; Xiaolan Zhao; Line Due Buron; Uffe H Mortensen; Lumir Krejci; Michael Lisby
Journal:  DNA Repair (Amst)       Date:  2016-04-16

9.  Remarkably Long-Tract Gene Conversion Induced by Fragile Site Instability in Saccharomyces cerevisiae.

Authors:  Shahana A Chumki; Mikael K Dunn; Thomas F Coates; Jeanmarie D Mishler; Ellen M Younkin; Anne M Casper
Journal:  Genetics       Date:  2016-06-24       Impact factor: 4.562

10.  Phenotypic Consequences of a Spontaneous Loss of Heterozygosity in a Common Laboratory Strain of Candida albicans.

Authors:  Toni Ciudad; Meleah Hickman; Alberto Bellido; Judith Berman; Germán Larriba
Journal:  Genetics       Date:  2016-05-20       Impact factor: 4.562
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