Literature DB >> 20230527

The profile of KIR3DL1 and KIR3DS1 alleles in an African American population resembles that found in African populations.

B Jiang1, L Hou, M Chen, J Ng, C K Hurley.   

Abstract

KIR3DL1 and KIR3DS1 allele frequencies were determined by DNA sequencing of the complete coding regions from 100 random unrelated African Americans. Alleles 3DL1*01501 (29 individuals) and 3DL1*01502 (23 individuals) were most frequently observed in addition to 21 other known alleles and 7 new alleles: KIR3DL1*01503, *03102, *064, *065, *066, *067, and *068. Two of the new alleles (KIR3DL1*064, *065) created additional variants of the chimeric KIR3DL1/KIR3DL2 gene. KIR3DS1*01301 (94% of the gene positive individuals) and KIR3DS1*049N (11%) were identified in the 18 individuals carrying this gene. Three individuals appeared to carry a killer cell immunoglobulin-like receptor haplotype with KIR3DL1/S1 duplication. The profile of alleles resembles that found in African populations but also shows signs of admixture.

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Year:  2010        PMID： 20230527      PMCID： PMC3485638          DOI： 10.1111/j.1399-0039.2010.01468.x

Source DB:  PubMed          Journal:  Tissue Antigens        ISSN： 0001-2815


  18 in total

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Journal:  Nat Genet       Date:  2007-08-12       Impact factor: 38.330

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Journal:  Tissue Antigens       Date:  2003-07

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Journal:  J Immunol       Date:  2007-01-01       Impact factor: 5.422

10.  The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor.

Authors:  J E Gumperz; V Litwin; J H Phillips; L L Lanier; P Parham
Journal:  J Exp Med       Date:  1995-03-01       Impact factor: 14.307
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Authors:  S D Tao; Y M He; Y L Ying; J He; F M Zhu; H J Lv
Journal:  Genes Immun       Date:  2013-10-31       Impact factor: 2.676

3.  The characteristics of allelic polymorphism in killer-immunoglobulin-like receptor framework genes in African Americans.

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  6 in total

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