Literature DB >> 20227034

IDH1 and IDH2: not your typical oncogenes.

Zachary J Reitman1, D Williams Parsons, Hai Yan.   

Abstract

Oncogenes usually increase their normal function when activated. However, seemingly oncogenic mutations in IDH1 and IDH2 reduce their native enzyme activity. In this issue of Cancer Cell, Ward et al. pin down a neomorphic enzyme activity as a possible oncogenic function for these alterations. Copyright 2010 Elsevier Inc. All rights reserved.

Entities:  

Year:  2010        PMID： 20227034      PMCID： PMC4467912          DOI： 10.1016/j.ccr.2010.02.024

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

1.  IDH1 mutations in gliomas: when an enzyme loses its grip.

Authors:  Christian Frezza; Daniel A Tennant; Eyal Gottlieb
Journal:  Cancer Cell       Date:  2010-01-19       Impact factor: 31.743

2.  Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations.

Authors:  Stefan Gross; Rob A Cairns; Mark D Minden; Edward M Driggers; Mark A Bittinger; Hyun Gyung Jang; Masato Sasaki; Shengfang Jin; David P Schenkein; Shinsan M Su; Lenny Dang; Valeria R Fantin; Tak W Mak
Journal:  J Exp Med       Date:  2010-02-08       Impact factor: 17.579

3.  Cancer-associated IDH1 mutations produce 2-hydroxyglutarate.

Authors:  Lenny Dang; David W White; Stefan Gross; Bryson D Bennett; Mark A Bittinger; Edward M Driggers; Valeria R Fantin; Hyun Gyung Jang; Shengfang Jin; Marie C Keenan; Kevin M Marks; Robert M Prins; Patrick S Ward; Katharine E Yen; Linda M Liau; Joshua D Rabinowitz; Lewis C Cantley; Craig B Thompson; Matthew G Vander Heiden; Shinsan M Su
Journal:  Nature       Date:  2009-12-10       Impact factor: 49.962

4.  Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.

Authors:  Shimin Zhao; Yan Lin; Wei Xu; Wenqing Jiang; Zhengyu Zha; Pu Wang; Wei Yu; Zhiqiang Li; Lingling Gong; Yingjie Peng; Jianping Ding; Qunying Lei; Kun-Liang Guan; Yue Xiong
Journal:  Science       Date:  2009-04-10       Impact factor: 47.728

5.  Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation.

Authors:  Wen-Chien Chou; Hsin-An Hou; Chien-Yuan Chen; Jih-Luh Tang; Ming Yao; Woei Tsay; Bor-Shen Ko; Shang-Ju Wu; Shang-Yi Huang; Szu-Chun Hsu; Yao-Chang Chen; Yen-Ning Huang; Yi-Chang Chang; Fen-Yu Lee; Ming-Chi Liu; Chia-Wen Liu; Mei-Hsuan Tseng; Chi-Fei Huang; Hwei-Fang Tien
Journal:  Blood       Date:  2010-01-22       Impact factor: 22.113

6.  Recurring mutations found by sequencing an acute myeloid leukemia genome.

Authors:  Elaine R Mardis; Li Ding; David J Dooling; David E Larson; Michael D McLellan; Ken Chen; Daniel C Koboldt; Robert S Fulton; Kim D Delehaunty; Sean D McGrath; Lucinda A Fulton; Devin P Locke; Vincent J Magrini; Rachel M Abbott; Tammi L Vickery; Jerry S Reed; Jody S Robinson; Todd Wylie; Scott M Smith; Lynn Carmichael; James M Eldred; Christopher C Harris; Jason Walker; Joshua B Peck; Feiyu Du; Adam F Dukes; Gabriel E Sanderson; Anthony M Brummett; Eric Clark; Joshua F McMichael; Rick J Meyer; Jonathan K Schindler; Craig S Pohl; John W Wallis; Xiaoqi Shi; Ling Lin; Heather Schmidt; Yuzhu Tang; Carrie Haipek; Madeline E Wiechert; Jolynda V Ivy; Joelle Kalicki; Glendoria Elliott; Rhonda E Ries; Jacqueline E Payton; Peter Westervelt; Michael H Tomasson; Mark A Watson; Jack Baty; Sharon Heath; William D Shannon; Rakesh Nagarajan; Daniel C Link; Matthew J Walter; Timothy A Graubert; John F DiPersio; Richard K Wilson; Timothy J Ley
Journal:  N Engl J Med       Date:  2009-08-05       Impact factor: 91.245

7.  An integrated genomic analysis of human glioblastoma multiforme.

Authors:  D Williams Parsons; Siân Jones; Xiaosong Zhang; Jimmy Cheng-Ho Lin; Rebecca J Leary; Philipp Angenendt; Parminder Mankoo; Hannah Carter; I-Mei Siu; Gary L Gallia; Alessandro Olivi; Roger McLendon; B Ahmed Rasheed; Stephen Keir; Tatiana Nikolskaya; Yuri Nikolsky; Dana A Busam; Hanna Tekleab; Luis A Diaz; James Hartigan; Doug R Smith; Robert L Strausberg; Suely Kazue Nagahashi Marie; Sueli Mieko Oba Shinjo; Hai Yan; Gregory J Riggins; Darell D Bigner; Rachel Karchin; Nick Papadopoulos; Giovanni Parmigiani; Bert Vogelstein; Victor E Velculescu; Kenneth W Kinzler
Journal:  Science       Date:  2008-09-04       Impact factor: 47.728

8.  The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate.

Authors:  Patrick S Ward; Jay Patel; David R Wise; Omar Abdel-Wahab; Bryson D Bennett; Hilary A Coller; Justin R Cross; Valeria R Fantin; Cyrus V Hedvat; Alexander E Perl; Joshua D Rabinowitz; Martin Carroll; Shinsan M Su; Kim A Sharp; Ross L Levine; Craig B Thompson
Journal:  Cancer Cell       Date:  2010-02-18       Impact factor: 38.585

9.  Somatic mutations of IDH1 and IDH2 in the leukemic transformation of myeloproliferative neoplasms.

Authors:  Anthony Green; Philip Beer
Journal:  N Engl J Med       Date:  2010-01-28       Impact factor: 176.079

10.  IDH1 and IDH2 mutations in gliomas.

Authors:  Hai Yan; D Williams Parsons; Genglin Jin; Roger McLendon; B Ahmed Rasheed; Weishi Yuan; Ivan Kos; Ines Batinic-Haberle; Siân Jones; Gregory J Riggins; Henry Friedman; Allan Friedman; David Reardon; James Herndon; Kenneth W Kinzler; Victor E Velculescu; Bert Vogelstein; Darell D Bigner
Journal:  N Engl J Med       Date:  2009-02-19       Impact factor: 176.079
  10 in total
  30 in total

1.  Differential expression of alternatively spliced transcripts related to energy metabolism in colorectal cancer.

Authors:  Anastasiya Vladimirovna Snezhkina; George Sergeevich Krasnov; Andrew Rostislavovich Zaretsky; Alex Zhavoronkov; Kirill Mikhailovich Nyushko; Alexey Alexandrovich Moskalev; Irina Yurievna Karpova; Anastasiya Isaevna Afremova; Anastasiya Valerievna Lipatova; Dmitriy Vladimitovich Kochetkov; Maria Sergeena Fedorova; Nadezhda Nikolaevna Volchenko; Asiya Fayazovna Sadritdinova; Nataliya Vladimirovna Melnikova; Dmitry Vladimirovich Sidorov; Anatoly Yurievich Popov; Dmitry Valerievich Kalinin; Andrey Dmitrievich Kaprin; Boris Yakovlevich Alekseev; Alexey Alexandrovich Dmitriev; Anna Viktorovna Kudryavtseva
Journal:  BMC Genomics       Date:  2016-12-28       Impact factor: 3.969

Review 2.  Proteins moonlighting in tumor metabolism and epigenetics.

Authors:  Lei Lv; Qunying Lei
Journal:  Front Med       Date:  2021-01-02       Impact factor: 4.592

Review 3.  Malignant glioma: lessons from genomics, mouse models, and stem cells.

Authors:  Jian Chen; Renée M McKay; Luis F Parada
Journal:  Cell       Date:  2012-03-30       Impact factor: 41.582

Review 4.  Cholangiocarcinoma.

Authors:  Nataliya Razumilava; Gregory J Gores
Journal:  Lancet       Date:  2014-02-26       Impact factor: 79.321

5.  Up-regulated isocitrate dehydrogenase 1 suppresses proliferation, migration and invasion in osteosarcoma: in vitro and in vivo.

Authors:  Xiang Hu; Yang Liu; Chunxia Qin; Zhenyu Pan; Jun Luo; Aixi Yu; Zhen Cheng
Journal:  Cancer Lett       Date:  2013-12-22       Impact factor: 8.679

Review 6.  IDH mutations in human glioma.

Authors:  Won Kim; Linda M Liau
Journal:  Neurosurg Clin N Am       Date:  2012-05-31       Impact factor: 2.509

7.  Mutant IDH1-driven cellular transformation increases RAD51-mediated homologous recombination and temozolomide resistance.

Authors:  Shigeo Ohba; Joydeep Mukherjee; Wendy L See; Russell O Pieper
Journal:  Cancer Res       Date:  2014-07-17       Impact factor: 12.701

Review 8.  Molecular pathogenesis of cholangiocarcinoma.

Authors:  Sumera Rizvi; Gregory J Gores
Journal:  Dig Dis       Date:  2014-07-14       Impact factor: 2.404

Review 9.  Pathogenesis, diagnosis, and management of cholangiocarcinoma.

Authors:  Sumera Rizvi; Gregory J Gores
Journal:  Gastroenterology       Date:  2013-10-15       Impact factor: 22.682

10.  Pretreatment d-2-hydroxyglutarate serum levels negatively impact on outcome in IDH1-mutated acute myeloid leukemia.

Authors:  J Balss; C Thiede; T Bochtler; J G Okun; M Saadati; A Benner; S Pusch; G Ehninger; M Schaich; A D Ho; A von Deimling; A Krämer; C E Heilig
Journal:  Leukemia       Date:  2015-11-19       Impact factor: 11.528
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