Literature DB >> 24368190

Up-regulated isocitrate dehydrogenase 1 suppresses proliferation, migration and invasion in osteosarcoma: in vitro and in vivo.

Xiang Hu1, Yang Liu2, Chunxia Qin2, Zhenyu Pan3, Jun Luo4, Aixi Yu5, Zhen Cheng6.   

Abstract

Very few studies have been reported the function of wild type IDH1 in tumor progress. Previously, we reported that IDH1 correlated with pathological grade and metastatic potential inversely in human osteosarcoma. Here, IDH1 was found lower expressed in osteosarcoma tissues than that of adjacent normal bone tissues. In addition, we observed in vitro anti-proliferation and pro-apoptosis effects of up-regulated IDH1 on osteosarcoma cell lines. The migration and invasion activity was also markedly reduced by IDH1 up-regulation. Unexpectedly, IDH1 up-regulation also suppressed tumor growth and metastasis in vivo. Therefore, IDH1 may represent a potential novel treatment and preventive strategy for osteosarcoma.
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Entities:  

Keywords:  Invasion; Isocitrate dehydrogenase 1; Migration; Osteosarcoma; Proliferation

Mesh：

Substances：

Year:  2013        PMID： 24368190      PMCID： PMC4363565          DOI： 10.1016/j.canlet.2013.12.020

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  25 in total

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2.  Cytosolic isocitrate dehydrogenase in humans, mice, and voles and phylogenetic analysis of the enzyme family.

Authors:  A Nekrutenko; D M Hillis; J C Patton; R D Bradley; R J Baker
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3.  Functional and biological analysis of Bcl-xL expression in human osteosarcoma.

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Authors:  Ashfaque A Memon; Jong W Chang; Bong R Oh; Yung J Yoo
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5.  IDH1 and IDH2: not your typical oncogenes.

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Journal:  Cancer Cell       Date:  2010-03-16       Impact factor: 31.743

6.  Insulin-like growth factor binding protein 5 suppresses tumor growth and metastasis of human osteosarcoma.

Authors:  Y Su; E R Wagner; Q Luo; J Huang; L Chen; B-C He; G-W Zuo; Q Shi; B-Q Zhang; G Zhu; Y Bi; J Luo; X Luo; S H Kim; J Shen; F Rastegar; E Huang; Y Gao; J-L Gao; K Yang; C Wietholt; M Li; J Qin; R C Haydon; T-C He; H H Luu
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Review 7.  The role of high-dose therapy and autologous stem cell transplantation for pediatric bone and soft tissue sarcomas.

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10.  Selective killing of tumors deficient in methylthioadenosine phosphorylase: a novel strategy.

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3.  [RHPN2 is highly expressed in osteosarcoma cells to promote cell proliferation and migration and inhibit apoptosis].

Authors:  Z Liu; F Fang; J Li; G Zhao; Q Zang; F Zhang; J Die
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4.  IDH2 reprograms mitochondrial dynamics in cancer through a HIF-1α-regulated pseudohypoxic state.

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Journal:  FASEB J       Date:  2019-09-17       Impact factor: 5.834

5.  lncRNA CEBPA-AS1 Overexpression Inhibits Proliferation and Migration and Stimulates Apoptosis of OS Cells via Notch Signaling.

Authors:  Peng Xia; Rui Gu; Wei Zhang; Yi-Fu Sun
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7.  Long non-coding RNA PGM5-AS1 promotes epithelial-mesenchymal transition, invasion and metastasis of osteosarcoma cells by impairing miR-140-5p-mediated FBN1 inhibition.

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Review 8.  Osteosarcoma and Metastasis.

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  8 in total

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