Literature DB >> 2021589

Effect on mydriasis of modifying the volume of phenylephrine drops.

E W Craig1, P G Griffiths.   

Abstract

The cardiovascular effects of topically administered phenylephrine 10% are well known and can be minimised by reducing the concentration of drops administered. By modifying the dimensions of the dropper tip we reduced the volume of the drops administered, and therefore the total dose of phenylephrine, without altering the concentration. No difference in the mydriasis produced by drops of small and normal volume could be detected. Since a smaller dose of phenylephrine is administered with smaller drops, the risk of systemic side effects could be reduced by modifying the tips of eyedroppers.

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Year:  1991        PMID： 2021589      PMCID： PMC1042326          DOI： 10.1136/bjo.75.4.222

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN： 0007-1161            Impact factor:   4.638


  10 in total

1.  Quantitative precorneal disposition of topically applied pilocarpine nitrate in rabbit eyes.

Authors:  T F Patton; J R Robinson
Journal:  J Pharm Sci       Date:  1976-09       Impact factor: 3.534

2.  Creating smaller eyedrops by reducing eyedropper tip dimensions.

Authors:  R H Brown; M L Hotchkiss; E B Davis
Journal:  Am J Ophthalmol       Date:  1985-04-15       Impact factor: 5.258

3.  Punctal occlusion and topical medications for glaucoma.

Authors:  T C Huang; D A Lee
Journal:  Am J Ophthalmol       Date:  1989-02-15       Impact factor: 5.258

4.  Design of eyedropper tips for topical beta-blocking agents.

Authors:  R H Brown; M G Lynch
Journal:  Am J Ophthalmol       Date:  1986-07-15       Impact factor: 5.258

Review 5.  Pharmacokinetics of topically applied ophthalmic drugs.

Authors:  J W Shell
Journal:  Surv Ophthalmol       Date:  1982 Jan-Feb       Impact factor: 6.048

6.  Possible adverse effects from topical ocular 10% phenylephrine.

Authors:  F T Fraunfelder; A F Scafidi
Journal:  Am J Ophthalmol       Date:  1978-04       Impact factor: 5.258

7.  Systemic absorption and cardiovascular effects of phenylephrine eyedrops.

Authors:  V Kumar; R D Schoenwald; D S Chien; A J Packer; W W Choi
Journal:  Am J Ophthalmol       Date:  1985-02-15       Impact factor: 5.258

8.  Improving the therapeutic index of topically applied ocular drugs.

Authors:  T J Zimmerman; K S Kooner; A S Kandarakis; L P Ziegler
Journal:  Arch Ophthalmol       Date:  1984-04

9.  Adverse effect of intraoperative phenylephrine 10%: case report.

Authors:  Y K Lai
Journal:  Br J Ophthalmol       Date:  1989-06       Impact factor: 4.638

10.  Comparison of conjunctival and corneal surface areas in rabbit and human.

Authors:  M A Watsky; M M Jablonski; H F Edelhauser
Journal:  Curr Eye Res       Date:  1988-05       Impact factor: 2.424
  10 in total
  1 in total

1.  Short-term Analysis of the Residual Volume of an Eye Drop Following 23-Gauge Microincision Vitrectomy Surgery.

Authors:  Yong Koo Kang; Jong Chan Im; Jae Pil Shin; In Taek Kim; Dong Ho Park
Journal:  Korean J Ophthalmol       Date:  2017-07-06
  1 in total

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