Literature DB >> 2751981

Adverse effect of intraoperative phenylephrine 10%: case report.

Y K Lai1.   

Abstract

The case is reported of a patient who suffered severe acute hypertension, cardiac arrhythmia, and myocardial infarction probably as a direct effect of phenylephrine overdose. Instillation of the drops during surgery probably enhanced the systemic absorption of a significant amount of the drug. Therefore it should be used during surgery with caution, especially in elderly patients and those with cardiovascular disease.

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Year:  1989        PMID: 2751981      PMCID: PMC1041770          DOI: 10.1136/bjo.73.6.468

Source DB:  PubMed          Journal:  Br J Ophthalmol        ISSN: 0007-1161            Impact factor:   4.638


  2 in total

1.  Hazards of the use of sympathomimetic drugs in ophthalmology.

Authors:  W H HAVENER; J W HENDERSON; W U MCREYNOLDS
Journal:  AMA Arch Ophthalmol       Date:  1956-08

2.  Possible adverse effects from topical ocular 10% phenylephrine.

Authors:  F T Fraunfelder; A F Scafidi
Journal:  Am J Ophthalmol       Date:  1978-04       Impact factor: 5.258

  2 in total
  7 in total

1.  Effect on mydriasis of modifying the volume of phenylephrine drops.

Authors:  E W Craig; P G Griffiths
Journal:  Br J Ophthalmol       Date:  1991-04       Impact factor: 4.638

2.  Intraoperative pulseless electrical activity and acute cardiogenic shock after administration of phenylephrine, epinephrine, and ketamine.

Authors:  Alan D Kaye; Alecia L Sabartinelli; Adam M Kaye; Alan M Holtzman; Paul L Samm
Journal:  Ochsner J       Date:  2010

3.  Characterizing Current Attitudes and Practices for Human Subject Safety in Studies Involving Pupil Dilation.

Authors:  Jacob Szpernal; Joseph Carroll; Ryan Spellecy; Jane A Bachman Groth
Journal:  J Empir Res Hum Res Ethics       Date:  2020-11-02       Impact factor: 1.742

Review 4.  Systemic adverse effects of topical ophthalmic agents. Implications for older patients.

Authors:  J P Diamond
Journal:  Drugs Aging       Date:  1997-11       Impact factor: 3.923

5.  Pupillary Dilation in Research: More than Meets the Eye.

Authors:  Jacob Szpernal; Jane A Bachman Groth; Niamh Wynne; Vesper Williams; Ryan Spellecy; Catherine Thuruthumaly; Joseph Carroll
Journal:  Curr Eye Res       Date:  2022-05-02       Impact factor: 2.555

Review 6.  Potential cardiovascular adverse events when phenylephrine is combined with paracetamol: simulation and narrative review.

Authors:  Hartley C Atkinson; Amanda L Potts; Brian J Anderson
Journal:  Eur J Clin Pharmacol       Date:  2015-05-29       Impact factor: 2.953

Review 7.  Systemic side effects of eye drops: a pharmacokinetic perspective.

Authors:  Andre Farkouh; Peter Frigo; Martin Czejka
Journal:  Clin Ophthalmol       Date:  2016-12-07
  7 in total

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