Literature DB >> 3409715

Comparison of conjunctival and corneal surface areas in rabbit and human.

M A Watsky1, M M Jablonski, H F Edelhauser.   

Abstract

This comparative study shows the surface area ratio of conjunctiva to cornea to be two times larger in humans than in rabbits. This large heretofore unrecognized interspecies difference may affect the applicability of drug pharmacokinetic data obtained using rabbit models and should be taken into consideration in topical drug development and future comparative drug penetration studies between rabbit and man.

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Mesh：

Year:  1988        PMID： 3409715     DOI： 10.3109/02713688809031801

Source DB:  PubMed          Journal:  Curr Eye Res        ISSN： 0271-3683            Impact factor:   2.424


  33 in total

1.  Effect on mydriasis of modifying the volume of phenylephrine drops.

Authors:  E W Craig; P G Griffiths
Journal:  Br J Ophthalmol       Date:  1991-04       Impact factor: 4.638

2.  General Pharmacokinetic Model for Topically Administered Ocular Drug Dosage Forms.

Authors:  Feng Deng; Veli-Pekka Ranta; Heidi Kidron; Arto Urtti
Journal:  Pharm Res       Date:  2016-07-18       Impact factor: 4.200

3.  Formulation influence on conjunctival penetration of four beta blockers in the pigmented rabbit: a comparison with corneal penetration.

Authors:  P Ashton; S K Podder; V H Lee
Journal:  Pharm Res       Date:  1991-09       Impact factor: 4.200

4.  Controlled delivery of pirfenidone through vitamin E-loaded contact lens ameliorates corneal inflammation.

Authors:  Phillip Dixon; Tanushri Ghosh; Kalyani Mondal; Aditya Konar; Anuj Chauhan; Sarbani Hazra
Journal:  Drug Deliv Transl Res       Date:  2018-10       Impact factor: 4.617

5.  Regional differences in rat conjunctival ion transport activities.

Authors:  Dongfang Yu; William R Thelin; Troy D Rogers; M Jackson Stutts; Scott H Randell; Barbara R Grubb; Richard C Boucher
Journal:  Am J Physiol Cell Physiol       Date:  2012-07-18       Impact factor: 4.249

6.  L-662,583 is a topically effective ocular hypotensive carbonic anhydrase inhibitor in experimental animals.

Authors:  M F Sugrue; P Gautheron; P Mallorga; T E Nolan; S L Graham; H Schwam; K L Shepard; R L Smith
Journal:  Br J Pharmacol       Date:  1990-01       Impact factor: 8.739

7.  The effect of topical amiloride eye drops on tear quantity in rabbits.

Authors:  Shuya Hara; Akihiro Hazama; Masao Miyake; Takashi Kojima; Yasumasa Sasaki; Jun Shimazaki; Murat Dogru; Kazuo Tsubota
Journal:  Mol Vis       Date:  2010-11-04       Impact factor: 2.367

8.  Influence of drug lipophilicity on drug release from sclera after iontophoretic delivery of mixed micellar carrier system to human sclera.

Authors:  Poonam Chopra; Jinsong Hao; S Kevin Li
Journal:  J Pharm Sci       Date:  2012-11-13       Impact factor: 3.534

9.  Ocular pharmacokinetic modeling using corneal absorption and desorption rates from in vitro permeation experiments with cultured corneal epithelial cells.

Authors:  Veli-Pekka Ranta; Mirka Laavola; Elisa Toropainen; Kati-Sisko Vellonen; Anu Talvitie; Arto Urtti
Journal:  Pharm Res       Date:  2003-09       Impact factor: 4.200

10.  Transporter targeted gatifloxacin prodrugs: synthesis, permeability, and topical ocular delivery.

Authors:  Sunil K Vooturi; Rajendra S Kadam; Uday B Kompella
Journal:  Mol Pharm       Date:  2012-10-11       Impact factor: 4.939
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