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Literature DB >> 20209006

Antiulcerogenic activity of ethanolic leaf extract of Lasianthera africana.

Jude E Okokon¹, Bassey S Antia, Emem E Umoh.

Abstract

The effect of ethanolic leaf extract of Lasianthera africana on experimentally induced ulcer was studied in rats. The extract (1000 - 3000mg/kg) inhibited ethanol-induced, indomethacin - induced and reserpine -induced ulcer models in a dose dependent fashion. The various degrees of inhibitions were statistically significant (p<0.01). The effect of the extract was comparable to that of the standard drugs used. Thus, Lasianthera africana extract demonstrated a good antiulcer activity which supports the antiulcer effect of this plant in traditional medicine.

Entities: Chemical Disease Species

Keywords: Lasianthera africana; antiulcer; vegetable

Mesh：

Substances：

Year: 2009 PMID： 20209006 PMCID： PMC2816572

Source DB: PubMed Journal: Afr J Tradit Complement Altern Med ISSN： 2505-0044

15 in total

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Authors: B J Whittle; N Oren-Wolman; P H Guth
Journal: Am J Physiol Date: 1985-05

Antiulcerogenic activity of ethanolic leaf extract of Lasianthera africana.

1. Antidiarrhoeal and antiulcerogenic effects of methanolic extract of Asparagus pubescens root in rats.

Review 2. Anti-ulcer drugs of plant origin.

3. Antiulcerogenic activity of Alchornea castaneaefolia: effects on somatostatin, gastrin and prostaglandin.

4. The effects of 5-lipoxygenase inhibitors and leukotriene antagonists on the development of gastric lesions induced by nonsteroidal antiinflammatory drugs in mice.

5. NSAIDs, Cox-2 inhibitors, and the gut.

6. Gastroprotective effects of flavonoids in plant extracts.

Review 7. Flavonoids: old and new aspects of a class of natural therapeutic drugs.

8. Gastric vasoconstrictor actions of leukotriene C4, PGF2 alpha, and thromboxane mimetic U-46619 on rat submucosal microcirculation in vivo.

Review 9. The plant kingdom as a source of anti-ulcer remedies.

10. Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury.

Review 1. Biotechnological aspects of plants metabolites in the treatment of ulcer: A new prospective.

2. Toxicity status and antiulcerative potential of Sansevieria trifasciata leaf extract in Wistar rats.