Literature DB >> 20208522

Disulfide-directed histone ubiquitylation reveals plasticity in hDot1L activation.

Champak Chatterjee1, Robert K McGinty, Beat Fierz, Tom W Muir.   

Abstract

We have developed a readily accessible disulfide-directed methodology for the site-specific modification of histones by ubiquitin and ubiquitin-like proteins. The disulfide-linked analog of mono-ubiquitylated H2B stimulated the H3K79 methyltransferase activity of hDot1L to a similar extent as the native isopeptide linkage. This permitted structure-activity studies of ubiquitylated mononucleosomes that revealed plasticity in the mechanism of hDot1L stimulation and identified surfaces of ubiquitin important for activation.

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Year:  2010        PMID： 20208522     DOI： 10.1038/nchembio.315

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  21 in total

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Journal:  Nat Rev Mol Cell Biol       Date:  2001-03       Impact factor: 94.444

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Authors:  Vikki M Weake; Jerry L Workman
Journal:  Mol Cell       Date:  2008-03-28       Impact factor: 17.970

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Journal:  Mol Cell       Date:  2005-11-23       Impact factor: 17.970

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Journal:  Annu Rev Biochem       Date:  1998       Impact factor: 23.643

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Authors:  F G Whitby; G Xia; C M Pickart; C P Hill
Journal:  J Biol Chem       Date:  1998-12-25       Impact factor: 5.157

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Journal:  Biochemistry       Date:  1989-02-07       Impact factor: 3.162

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Authors:  M H West; W M Bonner
Journal:  Nucleic Acids Res       Date:  1980-10-24       Impact factor: 16.971

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10.  The site-specific installation of methyl-lysine analogs into recombinant histones.

Authors:  Matthew D Simon; Feixia Chu; Lisa R Racki; Cecile C de la Cruz; Alma L Burlingame; Barbara Panning; Geeta J Narlikar; Kevan M Shokat
Journal:  Cell       Date:  2007-03-09       Impact factor: 41.582
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  100 in total

Review 1.  Ubiquitin and proteasomes in transcription.

Authors:  Fuqiang Geng; Sabine Wenzel; William P Tansey
Journal:  Annu Rev Biochem       Date:  2012-03-08       Impact factor: 23.643

2.  Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation.

Authors:  Franziska Meier; Tharindumala Abeywardana; Abhinav Dhall; Nicholas P Marotta; Jobin Varkey; Ralf Langen; Champak Chatterjee; Matthew R Pratt
Journal:  J Am Chem Soc       Date:  2012-03-14       Impact factor: 15.419

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Authors:  Mahesh B Chandrasekharan; Fu Huang; Zu-Wen Sun
Journal:  Epigenetics       Date:  2010-08-16       Impact factor: 4.528

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Authors:  Daniel Rösner; Tatjana Schneider; Daniel Schneider; Martin Scheffner; Andreas Marx
Journal:  Nat Protoc       Date:  2015-09-24       Impact factor: 13.491

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Authors:  Matthew T Holt; Yael David; Sam Pollock; Zhanyun Tang; Jongcheol Jeon; Jaehoon Kim; Robert G Roeder; Tom W Muir
Journal:  Proc Natl Acad Sci U S A       Date:  2015-08-03       Impact factor: 11.205

Review 6.  The upstreams and downstreams of H3K79 methylation by DOT1L.

Authors:  Hanneke Vlaming; Fred van Leeuwen
Journal:  Chromosoma       Date:  2016-01-04       Impact factor: 4.316

7.  Synthesis of a Bis-thio-acetone (BTA) Analogue of the Lysine Isopeptide Bond and its Application to Investigate the Effects of Ubiquitination and SUMOylation on α-Synuclein Aggregation and Toxicity.

Authors:  Yuka E Lewis; Tharindumala Abeywardana; Yu Hsuan Lin; Ana Galesic; Matthew R Pratt
Journal:  ACS Chem Biol       Date:  2016-01-12       Impact factor: 5.100

8.  Site-selective protein-modification chemistry for basic biology and drug development.

Authors:  Nikolaus Krall; Filipa P da Cruz; Omar Boutureira; Gonçalo J L Bernardes
Journal:  Nat Chem       Date:  2015-11-30       Impact factor: 24.427

9.  Site-specific differences in proteasome-dependent degradation of monoubiquitinated α-synuclein.

Authors:  Tharindumala Abeywardana; Yu Hsuan Lin; Ruth Rott; Simone Engelender; Matthew R Pratt
Journal:  Chem Biol       Date:  2013-10-24

10.  ASH2L regulates ubiquitylation signaling to MLL: trans-regulation of H3 K4 methylation in higher eukaryotes.

Authors:  Lipeng Wu; Shirley Y Lee; Bo Zhou; Uyen T T Nguyen; Tom W Muir; Song Tan; Yali Dou
Journal:  Mol Cell       Date:  2013-02-28       Impact factor: 17.970
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