Literature DB >> 20207529

From hematopoietic progenitors to B cells: mechanisms of lineage restriction and commitment.

Julita Ramírez1, Kara Lukin, James Hagman.   

Abstract

The generation of B lymphocytes from hematopoietic progenitors requires lineage-specific transcription factors that progressively direct cell fate choices. Differentiation of hematopoietic stem cells to lymphoid progenitors requires Ikaros-dependent lineage priming and graded levels of PU.1, which are controlled by Ikaros and Gfi1. E2A drives expression of EBF1, which initiates B lineage specification. EBF1, in addition to Pax5, is necessary for commitment to the B cell lineage. As a model of gene activation in early B lymphopoiesis, mb-1 genes are activated sequentially by factors (e.g. EBF1) that initiate chromatin modifications before transcription. This review highlights the requisite interplay between transcription factors and epigenetic mechanisms in the context of B cell development. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20207529      PMCID： PMC2854230          DOI： 10.1016/j.coi.2010.02.003

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  55 in total

1.  Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes.

Authors:  J Kim; S Sif; B Jones; A Jackson; J Koipally; E Heller; S Winandy; A Viel; A Sawyer; T Ikeda; R Kingston; K Georgopoulos
Journal:  Immunity       Date:  1999-03       Impact factor: 31.745

2.  Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells.

Authors:  Holger Weishaupt; Mikael Sigvardsson; Joanne L Attema
Journal:  Blood       Date:  2009-11-03       Impact factor: 22.113

3.  Multilineage gene expression precedes commitment in the hemopoietic system.

Authors:  M Hu; D Krause; M Greaves; S Sharkis; M Dexter; C Heyworth; T Enver
Journal:  Genes Dev       Date:  1997-03-15       Impact factor: 11.361

4.  The helix-loop-helix gene E2A is required for B cell formation.

Authors:  Y Zhuang; P Soriano; H Weintraub
Journal:  Cell       Date:  1994-12-02       Impact factor: 41.582

5.  Coordinate regulation of B cell differentiation by the transcription factors EBF and E2A.

Authors:  M O'Riordan; R Grosschedl
Journal:  Immunity       Date:  1999-07       Impact factor: 31.745

6.  Selective defects in the development of the fetal and adult lymphoid system in mice with an Ikaros null mutation.

Authors:  J H Wang; A Nichogiannopoulou; L Wu; L Sun; A H Sharpe; M Bigby; K Georgopoulos
Journal:  Immunity       Date:  1996-12       Impact factor: 31.745

7.  Commitment to the B-lymphoid lineage depends on the transcription factor Pax5.

Authors:  S L Nutt; B Heavey; A G Rolink; M Busslinger
Journal:  Nature       Date:  1999-10-07       Impact factor: 49.962

8.  Failure of B-cell differentiation in mice lacking the transcription factor EBF.

Authors:  H Lin; R Grosschedl
Journal:  Nature       Date:  1995-07-20       Impact factor: 49.962

9.  PU.1 regulates the commitment of adult hematopoietic progenitors and restricts granulopoiesis.

Authors:  Aleksandar Dakic; Donald Metcalf; Ladina Di Rago; Sandra Mifsud; Li Wu; Stephen L Nutt
Journal:  J Exp Med       Date:  2005-05-02       Impact factor: 14.307

10.  EBF contains a novel zinc coordination motif and multiple dimerization and transcriptional activation domains.

Authors:  J Hagman; M J Gutch; H Lin; R Grosschedl
Journal:  EMBO J       Date:  1995-06-15       Impact factor: 11.598
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  54 in total

1.  DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth.

Authors:  Hwajin Lee; Andrew E Jaffe; Jason I Feinberg; Rakel Tryggvadottir; Shannon Brown; Carolina Montano; Martin J Aryee; Rafael A Irizarry; Julie Herbstman; Frank R Witter; Lynn R Goldman; Andrew P Feinberg; M Daniele Fallin
Journal:  Int J Epidemiol       Date:  2012-02       Impact factor: 7.196

Review 2.  Role of Kruppel-like factors in leukocyte development, function, and disease.

Authors:  Zhuoxiao Cao; Xinghui Sun; Basak Icli; Akm Khyrul Wara; Mark W Feinberg
Journal:  Blood       Date:  2010-07-08       Impact factor: 22.113

3.  Lineage determination in the immune system.

Authors:  Ellen V Rothenberg
Journal:  Immunol Rev       Date:  2010-11       Impact factor: 12.988

4.  Hoxa9 regulates Flt3 in lymphohematopoietic progenitors.

Authors:  Kimberly Gwin; Elena Frank; Ayoko Bossou; Kay L Medina
Journal:  J Immunol       Date:  2010-10-22       Impact factor: 5.422

Review 5.  Epigenetics of haematopoietic cell development.

Authors:  Howard Cedar; Yehudit Bergman
Journal:  Nat Rev Immunol       Date:  2011-06-10       Impact factor: 53.106

Review 6.  Transcriptional and epigenetic regulation of B cell development.

Authors:  Patricia Santos; Fortuna Arumemi; Kyung Soo Park; Lisa Borghesi; Christine Milcarek
Journal:  Immunol Res       Date:  2011-08       Impact factor: 2.829

Review 7.  B lymphocyte lineage specification, commitment and epigenetic control of transcription by early B cell factor 1.

Authors:  James Hagman; Julita Ramírez; Kara Lukin
Journal:  Curr Top Microbiol Immunol       Date:  2012       Impact factor: 4.291

8.  Clonal allelic predetermination of immunoglobulin-κ rearrangement.

Authors:  Marganit Farago; Chaggai Rosenbluh; Maya Tevlin; Shira Fraenkel; Sharon Schlesinger; Hagit Masika; Masha Gouzman; Grace Teng; David Schatz; Yoach Rais; Jacob H Hanna; Alexander Mildner; Steffen Jung; Gustavo Mostoslavsky; Howard Cedar; Yehudit Bergman
Journal:  Nature       Date:  2012-09-30       Impact factor: 49.962

9.  Late stages of hematopoiesis and B cell lymphopoiesis are regulated by α-synuclein, a key player in Parkinson's disease.

Authors:  Wenbin Xiao; Afshin Shameli; Clifford V Harding; Howard J Meyerson; Robert W Maitta
Journal:  Immunobiology       Date:  2014-07-22       Impact factor: 3.144

10.  Ectopic T cell receptor-α locus control region activity in B cells is suppressed by direct linkage to two flanking genes at once.

Authors:  Stefan Knirr; Janette Gomos-Klein; Blanca E Andino; Faith Harrow; Karl F Erhard; Damian Kovalovsky; Derek B Sant'Angelo; Benjamin D Ortiz
Journal:  PLoS One       Date:  2010-11-22       Impact factor: 3.240
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