Literature DB >> 20189814

Gentisides A and B, two new neuritogenic compounds from the traditional Chinese medicine Gentiana rigescens Franch.

Lijuan Gao1, Jinyou Li, Jianhua Qi.   

Abstract

Two new alkyl 2,3-dihydroxybenzoates, gentisides A and B, were isolated from the traditional Chinese medicine Gentiana rigescens Franch. Their structures and stereochemistry were elucidated by spectroscopic methods and chemical derivatization. These compounds showed a significant neuritogenic activity at 30 microM against PC12 cells that was comparable to that seen for the best nerve growth factor (NGF) concentration of 40 ng/mL. Gentisides A and B showed parallel activity, indicating that the observed structural difference at the end of their alkyl chain did not affect neuritogenic activity. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20189814     DOI： 10.1016/j.bmc.2010.02.004

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  12 in total

1.  Functionally Optimized Neuritogenic Farinosone C Analogs: SAR-Study and Investigations on Their Mode of Action.

Authors:  Patrick Burch; Andrea Chicca; Jürg Gertsch; Karl Gademann
Journal:  ACS Med Chem Lett       Date:  2013-12-06       Impact factor: 4.345

2.  Neuritogenic monoglyceride derived from the constituent of a marine fish for activating the PI3K/ERK/CREB signalling pathways in PC12 cells.

Authors:  Wei Yang; Yan Luo; Ruiqi Tang; Hui Zhang; Ying Ye; Lan Xiang; Jianhua Qi
Journal:  Int J Mol Sci       Date:  2013-12-12       Impact factor: 5.923

3.  Comprehensive Quality Assessment Based Specific Chemical Profiles for Geographic and Tissue Variation in Gentiana rigescens Using HPLC and FTIR Method Combined with Principal Component Analysis.

Authors:  Jie Li; Ji Zhang; Yan-Li Zhao; Heng-Yu Huang; Yuan-Zhong Wang
Journal:  Front Chem       Date:  2017-12-22       Impact factor: 5.221

4.  Quantitative and Qualitative Characterization of Gentiana rigescens Franch (Gentianaceae) on Different Parts and Cultivations Years by HPLC and FTIR Spectroscopy.

Authors:  Lu-Ming Qi; Ji Zhang; Yan-Li Zhao; Zhi-Tian Zuo; Hang Jin; Yuan-Zhong Wang
Journal:  J Anal Methods Chem       Date:  2017-06-01       Impact factor: 2.193

Review 5.  The role of bioactive compounds on the promotion of neurite outgrowth.

Authors:  Sandeep Vasant More; Sushruta Koppula; In-Su Kim; Hemant Kumar; Byung-Wook Kim; Dong-Kug Choi
Journal:  Molecules       Date:  2012-06-04       Impact factor: 4.411

6.  Cucurbitacin B induces neurogenesis in PC12 cells and protects memory in APP/PS1 mice.

Authors:  Jing Li; Kaiyue Sun; Makoto Muroi; Lijuan Gao; Young-Tae Chang; Hiroyuki Osada; Lan Xiang; Jianhua Qi
Journal:  J Cell Mol Med       Date:  2019-06-30       Impact factor: 5.310

7.  Optimization of Gentisides Extraction from Gentiana rigescens Franch. ex Hemsl. by Response Surface Methodology.

Authors:  Bowen Chu; Yao Shi; Zhimin Li; Hao Tian; Wanyi Li; Yuanzhong Wang
Journal:  J Anal Methods Chem       Date:  2015-12-24       Impact factor: 2.193

8.  Investigation of metabolites accumulation in medical plant Gentiana rigescens during different growing stage using LC-MS/MS and FT-IR.

Authors:  Yu Pan; Ji Zhang; Yan-Li Zhao; Yuan-Zhong Wang; Heng-Yu Huang
Journal:  Bot Stud       Date:  2015-05-27       Impact factor: 2.787

9.  Discrimination of Gentiana and Its Related Species Using IR Spectroscopy Combined with Feature Selection and Stacked Generalization.

Authors:  Tao Shen; Hong Yu; Yuan-Zhong Wang
Journal:  Molecules       Date:  2020-03-23       Impact factor: 4.411

10.  Gentiopicroside, a Secoiridoid Glycoside from Gentiana rigescens Franch, Extends the Lifespan of Yeast via Inducing Mitophagy and Antioxidative Stress.

Authors:  Qian Liu; Lihong Cheng; Akira Matsuura; Lan Xiang; Jianhua Qi
Journal:  Oxid Med Cell Longev       Date:  2020-08-02       Impact factor: 6.543
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