Literature DB >> 20189270

Synthesis, characterization and antihypertensive activity of pyridazinone derivatives.

Anees A Siddiqui1, Ravinesh Mishra, Mohammad Shaharyar.   

Abstract

Some 6-(substituted-phenyl)-2-(substitutedmethyl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by reacting 6-substituted-phenyl-4,5-dihydropyridazin-3(2H)-one with cyclic secondary amine under Mannich reaction conditions. The final compounds (15-70) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 16, 19, 24, 30, 39, 42 and 45 showed good antihypertensive activity. Copyright (c) 2010 Elsevier Masson SAS. All rights reserved.

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Year:  2010        PMID： 20189270     DOI： 10.1016/j.ejmech.2010.02.003

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  10 in total

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Authors:  Gheorghe Roman
Journal:  Eur J Med Chem       Date:  2014-10-30       Impact factor: 6.514

2.  5-[(tert-Butyl-diphenyl-sil-yloxy)meth-yl]pyridazin-3(2H)-one.

Authors:  María Carmen Costas-Lago; Tamara Costas; Noemí Vila; Carmen Terán
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-11-27

3.  4-[(tert-Butyl-diphenyl-sil-yloxy)meth-yl]pyridazin-3(2H)-one.

Authors:  María Carmen Costas-Lago; Tamara Costas; Noemí Vila; Pedro Besada
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2013-11-30

4.  Synthesis and biological evaluation of new 3(2H)-pyridazinone derivatives as non-toxic anti-proliferative compounds against human colon carcinoma HCT116 cells.

Authors:  Zeynep Özdemir; Semra Utku; Bijo Mathew; Simone Carradori; Giustino Orlando; Simonetta Di Simone; Mehmet Abdullah Alagöz; Azime Berna Özçelik; Mehtap Uysal; Claudio Ferrante
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

5.  Synthesis, Cytotoxicity and Anti-Proliferative Activity Against AGS Cells of New 3(2H)-Pyridazinone Derivatives Endowed with a Piperazinyl Linker.

Authors:  Mehmet Abdullah Alagöz; Zeynep Özdemir; Mehtap Uysal; Simone Carradori; Marialucia Gallorini; Alessia Ricci; Susi Zara; Bijo Mathew
Journal:  Pharmaceuticals (Basel)       Date:  2021-02-25

6.  Synthesis and antihypertensive screening of new derivatives of quinazolines linked with isoxazole.

Authors:  Mujeeb Ur Rahman; Ankita Rathore; Anees A Siddiqui; Gazala Parveen; M Shahar Yar
Journal:  Biomed Res Int       Date:  2014-06-12       Impact factor: 3.411

7.  Crystal structure of 4-chloro-2-[(5-eth-oxy-1,3,4-thia-diazol-2-yl)meth-yl]-5-(piperidin-1-yl)pyridazin-3(2H)-one.

Authors:  Hongsen Li; Xinfeng Ren; Ya Li; Linjing Zhao
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-09-20

8.  Synthesis and In Vitro Biological Evaluation of 1,3,4-Oxadiazol-2(3H)-one and Tetrahydropyridazine-3,6-dione Derivatives of Fatty Acids.

Authors:  Mohammad F Hassan; Abdul Rauf; Asif Sherwani; Mohammad Owais
Journal:  Sci Pharm       Date:  2015-06-09

9.  Synthesis, Characterization and Solubility Determination of 6-Phenyl-pyridazin-3(2H)-one in Different Pharmaceutical Solvents.

Authors:  Faiyaz Shakeel; Mohd Imran; Nazrul Haq; Sultan Alshehri; Md Khalid Anwer
Journal:  Molecules       Date:  2019-09-19       Impact factor: 4.411

10.  Experimental and Computational Approaches for Solubility Measurement of Pyridazinone Derivative in Binary (DMSO + Water) Systems.

Authors:  Faiyaz Shakeel; Sultan Alshehri; Mohd Imran; Nazrul Haq; Abdullah Alanazi; Md Khalid Anwer
Journal:  Molecules       Date:  2019-12-31       Impact factor: 4.411
  10 in total

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