BACKGROUND: Colonoscopic examination is the common pathway for positive screening tests detecting colorectal lesions. We evaluated a specific, quantitative high-throughput automatic immunochemical fecal occult blood test (Auto iFOBT) method for colorectal cancer (CRC) screening and to determine its concordance with physician assessments informed by complete colonoscopy, the gold-standard technique for evaluation of the colonic mucosa. METHODS: 1200 CRC symptomatic patients were recruited for a retrospective investigation. Colorectal neoplasia were localized by colonoscopy and cancer outcomes were enumerated according to severity. In addition, stool samples were collected and analyzed by Auto iFOBT to derive sensitivity, specificity, and positive predictive value. Qualitative colonoscopy and Auto iFOBT results were correlated, as were cancer severities and quantitative hemoglobin concentrations. RESULTS: Ninety-one patients were found positive for CRC; 50 mucosal, 20 submucosal, and 21 advanced. At standard cutoff, sensitivity was 60%, 90%, and 95%, respectively. Specificity and positive predictive value for all neoplasia and cancers were 89.6% and 86.4%, and 60.9% and 33.7%, respectively. Cancer severities could be approximated roughly according to hemoglobin concentrations. CONCLUSIONS: Specific qualitative 2-day Auto iFOBT is an accurate tool for the detection of colorectal cancer and therefore provides the basis for a large-scale screening program. Copyright 2010 Elsevier B.V. All rights reserved.
BACKGROUND: Colonoscopic examination is the common pathway for positive screening tests detecting colorectal lesions. We evaluated a specific, quantitative high-throughput automatic immunochemical fecal occult blood test (Auto iFOBT) method for colorectal cancer (CRC) screening and to determine its concordance with physician assessments informed by complete colonoscopy, the gold-standard technique for evaluation of the colonic mucosa. METHODS: 1200 CRC symptomatic patients were recruited for a retrospective investigation. Colorectal neoplasia were localized by colonoscopy and cancer outcomes were enumerated according to severity. In addition, stool samples were collected and analyzed by Auto iFOBT to derive sensitivity, specificity, and positive predictive value. Qualitative colonoscopy and Auto iFOBT results were correlated, as were cancer severities and quantitative hemoglobin concentrations. RESULTS: Ninety-one patients were found positive for CRC; 50 mucosal, 20 submucosal, and 21 advanced. At standard cutoff, sensitivity was 60%, 90%, and 95%, respectively. Specificity and positive predictive value for all neoplasia and cancers were 89.6% and 86.4%, and 60.9% and 33.7%, respectively. Cancer severities could be approximated roughly according to hemoglobin concentrations. CONCLUSIONS: Specific qualitative 2-day Auto iFOBT is an accurate tool for the detection of colorectal cancer and therefore provides the basis for a large-scale screening program. Copyright 2010 Elsevier B.V. All rights reserved.
Authors: Manny D Bacolod; Aashiq H Mirza; Jianmin Huang; Sarah F Giardina; Philip B Feinberg; Steven A Soper; Francis Barany Journal: J Mol Diagn Date: 2020-05-12 Impact factor: 5.568
Authors: Miren B Zubero; Eunate Arana-Arri; José I Pijoan; Isabel Portillo; Isabel Idigoras; Antonio López-Urrutia; Ana Samper; Begoña Uranga; Carmen Rodríguez; Luis Bujanda Journal: Front Pharmacol Date: 2014-01-10 Impact factor: 5.810
Authors: Joaquín Cubiella; Pablo Vega; María Salve; Marta Díaz-Ondina; Maria Teresa Alves; Enrique Quintero; Victoria Álvarez-Sánchez; Fernando Fernández-Bañares; Jaume Boadas; Rafel Campo; Luis Bujanda; Joan Clofent; Ángel Ferrandez; Leyanira Torrealba; Virginia Piñol; Daniel Rodríguez-Alcalde; Vicent Hernández; Javier Fernández-Seara Journal: BMC Med Date: 2016-08-31 Impact factor: 8.775