| Literature DB >> 33666711 |
Wenxian Zhang1, Guangchun Xiao1, Jun Chen1, Li Wang2, Qiongzheng Hu3, Jian Wu1, Wenhong Zhang1, Ming Song1, Jinwei Qiao1, Chonghai Xu1.
Abstract
Colorectal cancer (CRC) is associated with one of the highest rates of mortality among cancers worldwide. The early detection and management of CRC is imperative. Biomarkers play an important role in CRC screening tests, CRC treatment, and prognosis and clinical management; thus rapid and sensitive detection of biomarkers is helpful for early detection of CRC. In recent years, electrochemical biosensors for detecting CRC biomarkers have been widely investigated. In this review, different electrochemical detection methods for CRC biomarkers including immunosensors, aptasensors, and genosensors are summarized. Further, representative examples are provided that demonstrate the advantages of electrochemical sensors modified by various nanomaterials. Finally, the limitations and prospects of biomarkers and electrochemical sensors in detection are also discussed. Graphical abstract.Entities:
Keywords: Aptasensors; Biomarkers; Colorectal cancer; Electrochemical detection; Genosensor; Immunosensors; Nanomaterials
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Year: 2021 PMID: 33666711 DOI: 10.1007/s00216-021-03197-8
Source DB: PubMed Journal: Anal Bioanal Chem ISSN: 1618-2642 Impact factor: 4.142