Literature DB >> 17483308

Paradoxes of the EphB4 receptor in cancer.

Nicole K Noren1, Elena B Pasquale.   

Abstract

Recent findings have started to uncover the intriguing roles of the Eph family of receptor tyrosine kinases in normal epithelial cells and during oncogenic transformation. This review focuses on EphB4, an Eph receptor that has both tumor-suppressing and tumor-promoting activities in breast cancer. Understanding the multifaceted role of EphB4 in tumorigenesis may allow the development of new anticancer therapies.

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Year:  2007        PMID： 17483308     DOI： 10.1158/0008-5472.CAN-07-0525

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  62 in total

1.  Scram1 is a modifier of spinal cord resistance for astrocytoma on mouse Chr 5.

Authors:  Jessica Amlin-Van Schaick; Sungjin Kim; Karl W Broman; Karlyne M Reilly
Journal:  Mamm Genome       Date:  2011-12-08       Impact factor: 2.957

Review 2.  Molecular mechanisms of cell segregation and boundary formation in development and tumorigenesis.

Authors:  Eduard Batlle; David G Wilkinson
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-01-01       Impact factor: 10.005

Review 3.  Targeting Eph receptors with peptides and small molecules: progress and challenges.

Authors:  Roberta Noberini; Ilaria Lamberto; Elena B Pasquale
Journal:  Semin Cell Dev Biol       Date:  2011-10-25       Impact factor: 7.727

4.  Competition amongst Eph receptors regulates contact inhibition of locomotion and invasiveness in prostate cancer cells.

Authors:  Jonathan W Astin; Jennifer Batson; Shereen Kadir; Jessica Charlet; Raj A Persad; David Gillatt; Jon D Oxley; Catherine D Nobes
Journal:  Nat Cell Biol       Date:  2010-11-14       Impact factor: 28.824

Review 5.  Eph receptors and ephrins in cancer: bidirectional signalling and beyond.

Authors:  Elena B Pasquale
Journal:  Nat Rev Cancer       Date:  2010-03       Impact factor: 60.716

6.  EphB3 suppresses non-small-cell lung cancer metastasis via a PP2A/RACK1/Akt signalling complex.

Authors:  Guo Li; Xiao-Dan Ji; Hong Gao; Jiang-Sha Zhao; Jun-Feng Xu; Zhi-Jian Sun; Yue-Zhen Deng; Shuo Shi; Yu-Xiong Feng; Yin-Qiu Zhu; Tao Wang; Jing-Jing Li; Dong Xie
Journal:  Nat Commun       Date:  2012-02-07       Impact factor: 14.919

7.  EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures.

Authors:  Ombretta Salvucci; Dragan Maric; Matina Economopoulou; Shuhei Sakakibara; Simone Merlin; Antonia Follenzi; Giovanna Tosato
Journal:  Blood       Date:  2009-05-01       Impact factor: 22.113

8.  Small molecules can selectively inhibit ephrin binding to the EphA4 and EphA2 receptors.

Authors:  Roberta Noberini; Mitchell Koolpe; Satyamaheshwar Peddibhotla; Russell Dahl; Ying Su; Nicholas D P Cosford; Gregory P Roth; Elena B Pasquale
Journal:  J Biol Chem       Date:  2008-08-26       Impact factor: 5.157

Review 9.  The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting.

Authors:  Jill Wykosky; Waldemar Debinski
Journal:  Mol Cancer Res       Date:  2008-12       Impact factor: 5.852

10.  Design, synthesis and characterization of novel small molecular inhibitors of ephrin-B2 binding to EphB4.

Authors:  Srinivas Duggineni; Sayantan Mitra; Roberta Noberini; Xiaofeng Han; Nan Lin; Yan Xu; Wang Tian; Jing An; Elena B Pasquale; Ziwei Huang
Journal:  Biochem Pharmacol       Date:  2012-12-17       Impact factor: 5.858
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