Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Use of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step.

Literature DB >> 20173034

Use of the kinase inhibitor analog 1NM-PP1 reveals a role for Toxoplasma gondii CDPK1 in the invasion step.

Tatsuki Sugi¹, Kentaro Kato, Kyosuke Kobayashi, Shumpei Watanabe, Hitomi Kurokawa, Haiyan Gong, Kishor Pandey, Hitoshi Takemae, Hiroomi Akashi.

Abstract

Toxoplasma gondii CDPK1 (TgCDPK1) was found to be the target of the toxoplasmocidal compound 1NM-PP1. When TgCDPK1 was mutated at position 128 from glycine to methionine, resistance was gained. Inhibition of gliding motility without inhibition of micronemal secretion by 1NM-PP1 suggests a function for TgCDPK1 in gliding motility.

Entities: Chemical Disease Gene Mutation

Mesh：

Substances：

Year: 2010 PMID： 20173034 PMCID： PMC2863409 DOI： 10.1128/EC.00351-09

Source DB: PubMed Journal: Eukaryot Cell ISSN： 1535-9786

25 in total

Review 1. Lytic cycle of Toxoplasma gondii.

Authors: M W Black; J C Boothroyd
Journal: Microbiol Mol Biol Rev Date: 2000-09 Impact factor: 11.056

2. KinG: a database of protein kinases in genomes.

Authors: A Krupa; K R Abhinandan; N Srinivasan
Journal: Nucleic Acids Res Date: 2004-01-01 Impact factor: 16.971

Review 3. Novel chemical genetic approaches to the discovery of signal transduction inhibitors.

Authors: Kevan Shokat; Mark Velleca
Journal: Drug Discov Today Date: 2002-08-15 Impact factor: 7.851

4. Toxoplasma gondii attachment to host cells is regulated by a calmodulin-like domain protein kinase.

Authors: H Kieschnick; T Wakefield; C A Narducci; C Beckers
Journal: J Biol Chem Date: 2001-01-11 Impact factor: 5.157

5. Secretion of micronemal proteins is associated with toxoplasma invasion of host cells.

Authors: V B Carruthers; O K Giddings; L D Sibley
Journal: Cell Microbiol Date: 1999-11 Impact factor: 3.715

Review 6. Protein kinases 6. The eukaryotic protein kinase superfamily: kinase (catalytic) domain structure and classification.

Authors: S K Hanks; T Hunter
Journal: FASEB J Date: 1995-05 Impact factor: 5.191

Review 7. Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii.

Authors: D S Roos; R G Donald; N S Morrissette; A L Moulton
Journal: Methods Cell Biol Date: 1994 Impact factor: 1.441

8. Actin filament polymerization regulates gliding motility by apicomplexan parasites.

Authors: D M Wetzel; S Håkansson; K Hu; D Roos; L D Sibley
Journal: Mol Biol Cell Date: 2003-02 Impact factor: 4.138

9. TgM2AP participates in Toxoplasma gondii invasion of host cells and is tightly associated with the adhesive protein TgMIC2.

Authors: K E Rabenau; A Sohrabi; A Tripathy; C Reitter; J W Ajioka; F M Tomley; V B Carruthers
Journal: Mol Microbiol Date: 2001-08 Impact factor: 3.501

10. Molecular analyses of Toxoplasma gondii calmodulin-like domain protein kinase isoform 3.

Authors: Tatsuki Sugi; Kentaro Kato; Kyousuke Kobayashi; Kishor Pandey; Hitoshi Takemae; Hitomi Kurokawa; Yukinobu Tohya; Hiroomi Akashi
Journal: Parasitol Int Date: 2009-08-20 Impact factor: 2.230

34 in total

1. A parasite calcium switch and Achilles' heel revealed.

Authors: Christian Doerig; Oliver Billker
Journal: Nat Struct Mol Biol Date: 2010-05 Impact factor: 15.369

2. Comparative Monomethylarginine Proteomics Suggests that Protein Arginine Methyltransferase 1 (PRMT1) is a Significant Contributor to Arginine Monomethylation in Toxoplasma gondii.

Authors: Rama R Yakubu; Natalie C Silmon de Monerri; Edward Nieves; Kami Kim; Louis M Weiss
Journal: Mol Cell Proteomics Date: 2017-01-31 Impact factor: 5.911

3. The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries.

Authors: Moritz Treeck; John L Sanders; Joshua E Elias; John C Boothroyd
Journal: Cell Host Microbe Date: 2011-10-20 Impact factor: 21.023

4. The Toxoplasma gondii inhibitor-2 regulates protein phosphatase 1 activity through multiple motifs.

Authors: Quentin Deveuve; Kevin Lesage; Thomas Mouveaux; Mathieu Gissot
Journal: Parasitol Res Date: 2017-06-30 Impact factor: 2.289

5. Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.

Authors: Eric T Larson; Kayode K Ojo; Ryan C Murphy; Steven M Johnson; Zhongsheng Zhang; Jessica E Kim; David J Leibly; Anna M W Fox; Molly C Reid; Edward J Dale; B Gayani K Perera; Jae Kim; Stephen N Hewitt; Wim G J Hol; Christophe L M J Verlinde; Erkang Fan; Wesley C Van Voorhis; Dustin J Maly; Ethan A Merritt
Journal: J Med Chem Date: 2012-03-13 Impact factor: 7.446

6. Distinct signalling pathways control Toxoplasma egress and host-cell invasion.

Authors: Sebastian Lourido; Keliang Tang; L David Sibley
Journal: EMBO J Date: 2012-11-13 Impact factor: 11.598

7. Serum Albumin Stimulates Protein Kinase G-dependent Microneme Secretion in Toxoplasma gondii.

Authors: Kevin M Brown; Sebastian Lourido; L David Sibley
Journal: J Biol Chem Date: 2016-03-01 Impact factor: 5.157

8. CDPKs of Cryptosporidium parvum--stage-specific expression in vitro.

Authors: Manja Etzold; Matthias Lendner; Arwid Daugschies; Viktor Dyachenko
Journal: Parasitol Res Date: 2014-05-09 Impact factor: 2.289

9. Calcium-dependent protein kinase 1 is an essential regulator of exocytosis in Toxoplasma.

Authors: Sebastian Lourido; Joel Shuman; Chao Zhang; Kevan M Shokat; Raymond Hui; L David Sibley
Journal: Nature Date: 2010-05-20 Impact factor: 49.962

10. Optimizing small molecule inhibitors of calcium-dependent protein kinase 1 to prevent infection by Toxoplasma gondii.

Authors: Sebastian Lourido; Chao Zhang; Michael S Lopez; Keliang Tang; Jennifer Barks; Qiuling Wang; Scott A Wildman; Kevan M Shokat; L David Sibley
Journal: J Med Chem Date: 2013-03-26 Impact factor: 7.446