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Literature DB >> 20171510

Biomarkers and surrogate endpoints for normal-tissue effects of radiation therapy: the importance of dose-volume effects.

Søren M Bentzen¹, Matthew Parliament, Joseph O Deasy, Adam Dicker, Walter J Curran, Jacqueline P Williams, Barry S Rosenstein.

Abstract

Biomarkers are of interest for predicting or monitoring normal tissue toxicity of radiation therapy. Advances in molecular radiobiology provide novel leads in the search for normal tissue biomarkers with sufficient sensitivity and specificity to become clinically useful. This article reviews examples of studies of biomarkers as predictive markers, as response markers, or as surrogate endpoints for radiation side effects. Single nucleotide polymorphisms are briefly discussed in the context of candidate gene and genomewide association studies. The importance of adjusting for radiation dose distribution in normal tissue biomarker studies is underlined. Finally, research priorities in this field are identified and discussed. Copyright 2010 Elsevier Inc. All rights reserved.

Entities: Chemical Disease Gene Mutation Species

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Year: 2010 PMID： 20171510 PMCID： PMC3431963 DOI： 10.1016/j.ijrobp.2009.08.076

Source DB: PubMed Journal: Int J Radiat Oncol Biol Phys ISSN： 0360-3016 Impact factor: 7.038

35 in total

1. Association of DNA repair and steroid metabolism gene polymorphisms with clinical late toxicity in patients treated with conformal radiotherapy for prostate cancer.

Authors: Sambasivarao Damaraju; David Murray; Jennifer Dufour; Diana Carandang; Sten Myrehaug; Gino Fallone; Colin Field; Russell Greiner; John Hanson; Carol E Cass; Matthew Parliament
Journal: Clin Cancer Res Date: 2006-04-15 Impact factor: 12.531

2. The relation between tumour lethal doses and the radiosensitivity of tumour cells.

Authors: T R MUNRO; C W GILBERT
Journal: Br J Radiol Date: 1961-04 Impact factor: 3.039

3. Does transforming growth factor-beta1 predict for radiation-induced pneumonitis in patients treated for lung cancer?

Authors: Elizabeth S Evans; Zafer Kocak; Su-Min Zhou; Daniel A Kahn; Hong Huang; Donna R Hollis; Kim L Light; Mitchell S Anscher; Lawrence B Marks
Journal: Cytokine Date: 2006-09-18 Impact factor: 3.861

Review 4. Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology.

Authors: Søren M Bentzen
Journal: Nat Rev Cancer Date: 2006-09 Impact factor: 60.716

5. Erythropoietin: high profile, high scrutiny.

Authors: Jeffrey Crawford
Journal: J Clin Oncol Date: 2007-02-20 Impact factor: 44.544

Review 6. Surrogate end points for median overall survival in metastatic colorectal cancer: literature-based analysis from 39 randomized controlled trials of first-line chemotherapy.

Authors: Patricia A Tang; Søren M Bentzen; Eric X Chen; Lillian L Siu
Journal: J Clin Oncol Date: 2007-09-17 Impact factor: 44.544

7. Interleukin (IL)-1A and IL-6: applications to the predictive diagnostic testing of radiation pneumonitis.

Authors: Yuhchyau Chen; Ollivier Hyrien; Jacqueline Williams; Paul Okunieff; Therese Smudzin; Philip Rubin
Journal: Int J Radiat Oncol Biol Phys Date: 2005-05-01 Impact factor: 7.038

8. A genetically determined dose-volume histogram predicts for rectal bleeding among patients treated with prostate brachytherapy.

Authors: Jamie A Cesaretti; Richard G Stock; David P Atencio; Sheila A Peters; Christopher A Peters; Ryan J Burri; Nelson N Stone; Barry S Rosenstein
Journal: Int J Radiat Oncol Biol Phys Date: 2007-05-09 Impact factor: 7.038

9. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

Authors:
Journal: Nature Date: 2007-06-07 Impact factor: 49.962

10. Genome-wide association study identifies novel breast cancer susceptibility loci.

Authors: Douglas F Easton; Karen A Pooley; Alison M Dunning; Paul D P Pharoah; Deborah Thompson; Dennis G Ballinger; Jeffery P Struewing; Jonathan Morrison; Helen Field; Robert Luben; Nicholas Wareham; Shahana Ahmed; Catherine S Healey; Richard Bowman; Kerstin B Meyer; Christopher A Haiman; Laurence K Kolonel; Brian E Henderson; Loic Le Marchand; Paul Brennan; Suleeporn Sangrajrang; Valerie Gaborieau; Fabrice Odefrey; Chen-Yang Shen; Pei-Ei Wu; Hui-Chun Wang; Diana Eccles; D Gareth Evans; Julian Peto; Olivia Fletcher; Nichola Johnson; Sheila Seal; Michael R Stratton; Nazneen Rahman; Georgia Chenevix-Trench; Stig E Bojesen; Børge G Nordestgaard; Christen K Axelsson; Montserrat Garcia-Closas; Louise Brinton; Stephen Chanock; Jolanta Lissowska; Beata Peplonska; Heli Nevanlinna; Rainer Fagerholm; Hannaleena Eerola; Daehee Kang; Keun-Young Yoo; Dong-Young Noh; Sei-Hyun Ahn; David J Hunter; Susan E Hankinson; David G Cox; Per Hall; Sara Wedren; Jianjun Liu; Yen-Ling Low; Natalia Bogdanova; Peter Schürmann; Thilo Dörk; Rob A E M Tollenaar; Catharina E Jacobi; Peter Devilee; Jan G M Klijn; Alice J Sigurdson; Michele M Doody; Bruce H Alexander; Jinghui Zhang; Angela Cox; Ian W Brock; Gordon MacPherson; Malcolm W R Reed; Fergus J Couch; Ellen L Goode; Janet E Olson; Hanne Meijers-Heijboer; Ans van den Ouweland; André Uitterlinden; Fernando Rivadeneira; Roger L Milne; Gloria Ribas; Anna Gonzalez-Neira; Javier Benitez; John L Hopper; Margaret McCredie; Melissa Southey; Graham G Giles; Chris Schroen; Christina Justenhoven; Hiltrud Brauch; Ute Hamann; Yon-Dschun Ko; Amanda B Spurdle; Jonathan Beesley; Xiaoqing Chen; Arto Mannermaa; Veli-Matti Kosma; Vesa Kataja; Jaana Hartikainen; Nicholas E Day; David R Cox; Bruce A J Ponder
Journal: Nature Date: 2007-06-28 Impact factor: 49.962

24 in total

Review 1. Missing link between microRNA and prostate cancer.

Authors: Balraj Singh Gill; Jimi Marin Alex; Sanjeev Kumar
Journal: Tumour Biol Date: 2016-01-28

Review 2. Inclusion of dosimetric data as covariates in toxicity-related radiogenomic studies : A systematic review.

Authors: Noorazrul Yahya; Xin-Jane Chua; Hanani A Manan; Fuad Ismail
Journal: Strahlenther Onkol Date: 2018-05-17 Impact factor: 3.621

3. Redesigning radiotherapy quality assurance: opportunities to develop an efficient, evidence-based system to support clinical trials--report of the National Cancer Institute Work Group on Radiotherapy Quality Assurance.

Authors: Justin E Bekelman; James A Deye; Bhadrasain Vikram; Soren M Bentzen; Deborah Bruner; Walter J Curran; James Dignam; Jason A Efstathiou; T J FitzGerald; Coen Hurkmans; Geoffrey S Ibbott; J Jack Lee; Thomas E Merchant; Jeff Michalski; Jatinder R Palta; Richard Simon; Randal K Ten Haken; Robert Timmerman; Sean Tunis; C Norman Coleman; James Purdy
Journal: Int J Radiat Oncol Biol Phys Date: 2012-03-15 Impact factor: 7.038

4. An orthotopic non-small cell lung cancer model for image-guided small animal radiotherapy platforms.

Authors: Venus Sosa Iglesias; Stefan J van Hoof; Ana Vaniqui; Lotte Ejr Schyns; Natasja Lieuwes; Ala Yaromina; Linda Spiegelberg; Arjan J Groot; Frank Verhaegen; Jan Theys; Ludwig Dubois; Marc Vooijs
Journal: Br J Radiol Date: 2018-11-30 Impact factor: 3.039

5. Single-nucleotide polymorphisms of TGFβ1 and ATM associated with radiation-induced pneumonitis: a prospective cohort study of thoracic cancer patients in China.

Authors: Ying Xiao; Xianglin Yuan; Hong Qiu; Qianxia Li
Journal: Int J Clin Exp Med Date: 2015-09-15

Review 10. Strategic evaluation of interventions to prevent consequential late proctitis after prostate radiation therapy: new clinical trial designs should be considered.

Authors: Timothy N Showalter; Nolan A Wages; Nitin Ohri
Journal: Cancer Biol Ther Date: 2014-02-04 Impact factor: 4.742