| Literature DB >> 16979900 |
Elizabeth S Evans1, Zafer Kocak, Su-Min Zhou, Daniel A Kahn, Hong Huang, Donna R Hollis, Kim L Light, Mitchell S Anscher, Lawrence B Marks.
Abstract
The purpose of the study was to reassess the utility of transforming growth factor-beta-1 (TGF-beta1) together with dosimetric and tumor parameters as a predictor for radiation pneumonitis (RP). Of the 121 patients studied, 32 (26.4%) developed grade > or =1 RP, and 27 (22.3%) developed grade > or =2 RP. For the endpoint of grade > or =1 RP, those with V30>30% and an end-RT/baseline TGF-beta1 ratio> or =1 had a significantly higher incidence of RP than did those with V30>30% and an end-RT/baseline TGF-beta1 ratio<1. For most other patient groups, there were no clear associations between TGF-beta1 values and rates of RP. These findings suggest that TGF-beta1 is generally not predictive for RP except for the group of patients with a high V30.Entities:
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Year: 2006 PMID： 16979900 PMCID： PMC1829192 DOI： 10.1016/j.cyto.2006.07.021
Source DB: PubMed Journal: Cytokine ISSN： 1043-4666 Impact factor: 3.861