Literature DB >> 20170743

Angiotensin-converting enzymes and drug discovery in cardiovascular diseases.

Lijun Shi1, Caiping Mao, Zhice Xu, Lubo Zhang.   

Abstract

Angiotensin-converting enzyme (ACE) is a major target in the treatment of cardiovascular diseases (CVDs). In addition to ACE, ACE2 - which is a homolog of ACE and promotes the degradation of angiotensin II (Ang II) to Ang (1-7) - has been recognized recently as a potential therapeutic target in the management of CVDs. This article reviews different metabolic pathways of ACE and ACE2 (Ang I-Ang II-AT1 receptors and Ang I-Ang (1-7)-Mas receptors) in the regulation of cardiovascular function and their potential in new drug development in the therapy of CVDs. In addition, recent progress in the study of angiotensin and ACE in fetal origins of CVD, which might present an interesting field in perinatal medicine and preventive medicine, is briefly summarized. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20170743      PMCID： PMC3005694          DOI： 10.1016/j.drudis.2010.02.003

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN： 1359-6446            Impact factor:   7.851


  103 in total

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Journal:  Circulation       Date:  2004-01-06       Impact factor: 29.690

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Journal:  Circulation       Date:  2003-09-22       Impact factor: 29.690

10.  Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis.

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  20 in total

1.  High Na intake increases renal angiotensin II levels and reduces expression of the ACE2-AT(2)R-MasR axis in obese Zucker rats.

Authors:  Preethi Samuel; Quaisar Ali; Rifat Sabuhi; Yonnie Wu; Tahir Hussain
Journal:  Am J Physiol Renal Physiol       Date:  2012-05-16

2.  Thrombospondin-1 and angiotensin II inhibit soluble guanylyl cyclase through an increase in intracellular calcium concentration.

Authors:  Saumya Ramanathan; Stacy Mazzalupo; Scott Boitano; William R Montfort
Journal:  Biochemistry       Date:  2011-08-16       Impact factor: 3.162

Review 3.  Fetal stress and programming of hypoxic/ischemic-sensitive phenotype in the neonatal brain: mechanisms and possible interventions.

Authors:  Yong Li; Pablo Gonzalez; Lubo Zhang
Journal:  Prog Neurobiol       Date:  2012-05-22       Impact factor: 11.685

4.  A novel rodent model of pregnancy complications associated with genetically determined angiotensin-converting enzyme (ACE) activity.

Authors:  Eugenia Mata-Greenwood; Arlin B Blood; LeeAnna D Sands; Shannon L Bragg; Daliao Xiao; Lubo Zhang
Journal:  Am J Physiol Endocrinol Metab       Date:  2018-01-23       Impact factor: 4.310

5.  High-salt diets during pregnancy affected fetal and offspring renal renin-angiotensin system.

Authors:  Caiping Mao; Rong Liu; Le Bo; Ningjing Chen; Shigang Li; Shuixiu Xia; Jie Chen; Dawei Li; Lubo Zhang; Zhice Xu
Journal:  J Endocrinol       Date:  2013-06-01       Impact factor: 4.286

Review 6.  Angiotensin II receptors and drug discovery in cardiovascular disease.

Authors:  Chiranjib Dasgupta; Lubo Zhang
Journal:  Drug Discov Today       Date:  2010-12-13       Impact factor: 7.851

Review 7.  Differential expression of microRNAs in ischemic heart disease.

Authors:  Minwoo A Song; Alexandra N Paradis; Maresha S Gay; John Shin; Lubo Zhang
Journal:  Drug Discov Today       Date:  2014-10-23       Impact factor: 7.851

8.  Understanding electrostatic and steric requirements related to hypertensive action of AT(1) antagonists using molecular modeling techniques.

Authors:  Danielle da C Silva; Vinicius G Maltarollo; Emmanuela Ferreira de Lima; Karen Cacilda Weber; Kathia M Honorio
Journal:  J Mol Model       Date:  2014-06-17       Impact factor: 1.810

9.  Antenatal betamethasone exposure is associated with lower ANG-(1-7) and increased ACE in the CSF of adult sheep.

Authors:  Allyson C Marshall; Hossam A Shaltout; Nancy T Pirro; James C Rose; Debra I Diz; Mark C Chappell
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2013-08-15       Impact factor: 3.619

10.  Effects of rosuvastatin on expression of angiotensin-converting enzyme 2 after vascular balloon injury in rats.

Authors:  Yong-Hong Li; Qi-Xin Wang; Jing-Wei Zhou; Xian-Ming Chu; Yu-Lin Man; Ping Liu; Bei-Bei Ren; Ting-Ru Sun; Yi An
Journal:  J Geriatr Cardiol       Date:  2013-06       Impact factor: 3.327
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