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Literature DB >> 21147255

Angiotensin II receptors and drug discovery in cardiovascular disease.

Abstract

Hypertension is one of the cardiovascular diseases that might cause cardiovascular remodeling and endothelial dysfunction besides high blood pressure. Angiotensin II (Ang II) receptors are implicated in hypertension. Genetic and epigenetic manipulations of the Ang II receptors play a crucial part in the programming of cardiovascular diseases, and certain variants of the Ang II type 1 and Ang II type 2 receptors are constitutively predisposed to higher cardiovascular risk and hypertension. In this review, we focus on the expression, mode of action of Ang II receptors, and their role in programming the cardiovascular diseases in utero. In addition, we discuss possible therapeutic interventions of Ang II stimulation. Collectively, this information might lead us to new drug designs against cardiovascular diseases.

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Year: 2010 PMID： 21147255 PMCID： PMC3022115 DOI： 10.1016/j.drudis.2010.11.016

Source DB: PubMed Journal: Drug Discov Today ISSN： 1359-6446 Impact factor: 7.851

139 in total

1. The angiotensin II AT2 receptor is an AT1 receptor antagonist.

Authors: S AbdAlla; H Lother; A M Abdel-tawab; U Quitterer
Journal: J Biol Chem Date: 2001-08-15 Impact factor: 5.157

2. Angiotensin II-induced insulin resistance is associated with enhanced insulin signaling.

Authors: Takehide Ogihara; Tomoichiro Asano; Katsuyuki Ando; Yuko Chiba; Hideyuki Sakoda; Motonobu Anai; Nobuhiro Shojima; Hiraku Ono; Yukiko Onishi; Midori Fujishiro; Hideki Katagiri; Yasushi Fukushima; Masatoshi Kikuchi; Noriko Noguchi; Hiroyuki Aburatani; Issei Komuro; Toshiro Fujita
Journal: Hypertension Date: 2002-12 Impact factor: 10.190

3. p47phox associates with the cytoskeleton through cortactin in human vascular smooth muscle cells: role in NAD(P)H oxidase regulation by angiotensin II.

Authors: R M Touyz; G Yao; M T Quinn; P J Pagano; E L Schiffrin
Journal: Arterioscler Thromb Vasc Biol Date: 2004-12-23 Impact factor: 8.311

4. Cross-talk between the insulin and angiotensin signaling systems.

Authors: L A Velloso; F Folli; X J Sun; M F White; M J Saad; C R Kahn
Journal: Proc Natl Acad Sci U S A Date: 1996-10-29 Impact factor: 11.205

5. Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II.

Authors: Koichi Yamamoto; Mitsuru Ohishi; Tomohiro Katsuya; Norihisa Ito; Masashi Ikushima; Masaharu Kaibe; Yuji Tatara; Atsushi Shiota; Sumio Sugano; Satoshi Takeda; Hiromi Rakugi; Toshio Ogihara
Journal: Hypertension Date: 2006-02-27 Impact factor: 10.190

Review 6. TGF-beta1 and angiotensin networking in cardiac remodeling.

Authors: Stephan Rosenkranz
Journal: Cardiovasc Res Date: 2004-08-15 Impact factor: 10.787

Review 7. Pathophysiological role of angiotensin II type 2 receptor in cardiovascular and renal diseases.

Authors: H Matsubara
Journal: Circ Res Date: 1998 Dec 14-28 Impact factor: 17.367

8. Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung.

Authors: G Koike; M Horiuchi; T Yamada; C Szpirer; H J Jacob; V J Dzau
Journal: Biochem Biophys Res Commun Date: 1994-09-30 Impact factor: 3.575

9. Cloning of cDNA and analysis of the gene for mouse angiotensin II type 2 receptor.

Authors: M Nakajima; M Mukoyama; R E Pratt; M Horiuchi; V J Dzau
Journal: Biochem Biophys Res Commun Date: 1993-12-15 Impact factor: 3.575

10. Maternal low-protein diet in rat pregnancy programs blood pressure through sex-specific mechanisms.

Authors: Sarah McMullen; Simon C Langley-Evans
Journal: Am J Physiol Regul Integr Comp Physiol Date: 2004-09-16 Impact factor: 3.619

34 in total

Review 1. The brain renin-angiotensin system: a diversity of functions and implications for CNS diseases.

Authors: John W Wright; Joseph W Harding
Journal: Pflugers Arch Date: 2012-04-26 Impact factor: 3.657

Review 2. Fetal hypoxia and programming of matrix metalloproteinases.

Authors: Wenni Tong; Lubo Zhang
Journal: Drug Discov Today Date: 2011-09-18 Impact factor: 7.851

Review 3. International Union of Basic and Clinical Pharmacology. XCIX. Angiotensin Receptors: Interpreters of Pathophysiological Angiotensinergic Stimuli [corrected].

Authors: Sadashiva S Karnik; Hamiyet Unal; Jacqueline R Kemp; Kalyan C Tirupula; Satoru Eguchi; Patrick M L Vanderheyden; Walter G Thomas
Journal: Pharmacol Rev Date: 2015-10 Impact factor: 25.468

Review 4. Fetal stress and programming of hypoxic/ischemic-sensitive phenotype in the neonatal brain: mechanisms and possible interventions.

Authors: Yong Li; Pablo Gonzalez; Lubo Zhang
Journal: Prog Neurobiol Date: 2012-05-22 Impact factor: 11.685

5. A novel rodent model of pregnancy complications associated with genetically determined angiotensin-converting enzyme (ACE) activity.

Authors: Eugenia Mata-Greenwood; Arlin B Blood; LeeAnna D Sands; Shannon L Bragg; Daliao Xiao; Lubo Zhang
Journal: Am J Physiol Endocrinol Metab Date: 2018-01-23 Impact factor: 4.310

6. Differential expression and DNA methylation of angiotensin type 1A receptors in vascular tissues during genetic hypertension development.

Authors: Fang Pei; Xinquan Wang; Rongchuan Yue; Caiyu Chen; Ji Huang; Jie Huang; Xiaohui Li; Chunyu Zeng
Journal: Mol Cell Biochem Date: 2015-01-18 Impact factor: 3.396