Literature DB >> 20161293

Evaluation of Chlorofusin, its Seven Chromophore Diastereomers, and Key Analogues.

Ryan C Clark1, Sang Yeul Lee, Inkyu Hwang, Mark Searcey, Dale L Boger.   

Abstract

Chlorofusin, its seven chromophore diastereomers, and key analogues were comparatively examined for inhibition of MDM2-p53 binding revealing that the chromophore, but not simple replacements, contributes significantly to the natural products properties, and that this contribution is independent of its relative and absolute stereochemistry.

Entities:  

Year:  2009        PMID： 20161293      PMCID： PMC2697908          DOI： 10.1016/j.tetlet.2009.01.081

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  26 in total

Review 1.  p53: death star.

Authors:  K H Vousden
Journal:  Cell       Date:  2000-11-22       Impact factor: 41.582

2.  Binding of an inhibitor of the p53/MDM2 interaction to MDM2.

Authors:  Sara J Duncan; Matthew A Cooper; Dudley H Williams
Journal:  Chem Commun (Camb)       Date:  2003-02-07       Impact factor: 6.222

Review 3.  Small-molecule inhibitors of the p53 suppressor HDM2: have protein-protein interactions come of age as drug targets?

Authors:  Peter M Fischer; David P Lane
Journal:  Trends Pharmacol Sci       Date:  2004-07       Impact factor: 14.819

4.  Total synthesis, stereochemical reassignment, and absolute configuration of chlorofusin.

Authors:  Sang Yeul Lee; Ryan C Clark; Dale L Boger
Journal:  J Am Chem Soc       Date:  2007-07-19       Impact factor: 15.419

5.  Mapping of the p53 and mdm-2 interaction domains.

Authors:  J Chen; V Marechal; A J Levine
Journal:  Mol Cell Biol       Date:  1993-07       Impact factor: 4.272

6.  Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.

Authors:  P H Kussie; S Gorina; V Marechal; B Elenbaas; J Moreau; A J Levine; N P Pavletich
Journal:  Science       Date:  1996-11-08       Impact factor: 47.728

Review 7.  The p53 tumour suppressor gene.

Authors:  A J Levine; J Momand; C A Finlay
Journal:  Nature       Date:  1991-06-06       Impact factor: 49.962

8.  Synthesis of the chlorofusin cyclic peptide: assignment of the asparagine stereochemistry.

Authors:  Pankaj Desai; Steven S Pfeiffer; Dale L Boger
Journal:  Org Lett       Date:  2003-12-25       Impact factor: 6.005

9.  Synthesis of the Chlorofusin Cyclic Peptide.

Authors:  Sang Yeul Lee; Dale L Boger
Journal:  Tetrahedron       Date:  2009       Impact factor: 2.457

10.  Total synthesis of chlorofusin, its seven chromophore diastereomers, and key partial structures.

Authors:  Ryan C Clark; Sang Yeul Lee; Dale L Boger
Journal:  J Am Chem Soc       Date:  2008-08-20       Impact factor: 15.419
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  1 in total

Review 1.  Pharmacological targets in the ubiquitin system offer new ways of treating cancer, neurodegenerative disorders and infectious diseases.

Authors:  Mariola J Edelmann; Benjamin Nicholson; Benedikt M Kessler
Journal:  Expert Rev Mol Med       Date:  2011-11-17       Impact factor: 5.600
  1 in total

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