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Literature DB >> 12613590

Binding of an inhibitor of the p53/MDM2 interaction to MDM2.

Sara J Duncan¹, Matthew A Cooper, Dudley H Williams.

Abstract

The mode of action of the secondary metabolite chlorofusin, which antagonises the interaction between p53 and MDM2, involves direct binding to the N-terminal domain of MDM2.

Entities: Chemical Gene

Mesh：

Substances：

Year: 2003 PMID： 12613590 DOI： 10.1039/b211889k

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

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Cited

14 in total

1. Total synthesis, stereochemical reassignment, and absolute configuration of chlorofusin.

Authors: Sang Yeul Lee; Ryan C Clark; Dale L Boger
Journal: J Am Chem Soc Date: 2007-07-19 Impact factor: 15.419

2. Beta-peptides with improved affinity for hDM2 and hDMX.

Authors: Elizabeth A Harker; Douglas S Daniels; Danielle A Guarracino; Alanna Schepartz
Journal: Bioorg Med Chem Date: 2009-01-23 Impact factor: 3.641

3. Cytotoxic effect of a non-peptidic small molecular inhibitor of the p53-HDM2 interaction on tumor cells.

Authors: Wen-Dong Li; Mi-Juan Wang; Fang Ding; Da-Li Yin; Zhi-Hua Liu
Journal: World J Gastroenterol Date: 2005-05-21 Impact factor: 5.742

Review 4. E3 ubiquitin ligases as cancer targets and biomarkers.

Authors: Yi Sun
Journal: Neoplasia Date: 2006-08 Impact factor: 5.715

Review 5. The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interaction.

Authors: Ryan C Clark; Sang Yeul Lee; Mark Searcey; Dale L Boger
Journal: Nat Prod Rep Date: 2009-04 Impact factor: 13.423

Binding of an inhibitor of the p53/MDM2 interaction to MDM2.

1. Total synthesis, stereochemical reassignment, and absolute configuration of chlorofusin.

2. Beta-peptides with improved affinity for hDM2 and hDMX.

3. Cytotoxic effect of a non-peptidic small molecular inhibitor of the p53-HDM2 interaction on tumor cells.

Review 4. E3 ubiquitin ligases as cancer targets and biomarkers.

Review 5. The isolation, total synthesis and structure elucidation of chlorofusin, a natural product inhibitor of the p53-mDM2 protein-protein interaction.

6. Therapeutic considerations for Mdm2: not just a one trick pony.

7. Synthesis of the Chlorofusin Cyclic Peptide.

8. Total synthesis of chlorofusin, its seven chromophore diastereomers, and key partial structures.

9. Evaluation of Chlorofusin, its Seven Chromophore Diastereomers, and Key Analogues.

10. Peptide, Peptidomimetic, and Small-molecule Antagonists of the p53-HDM2 Protein-Protein Interaction.