| Literature DB >> 2046748 |
A J Levine1, J Momand, C A Finlay.
Abstract
The cell cycle is composed of a series of steps which can be negatively or positively regulated by various factors. Chief among the negative regulators is the p53 protein. Alteration or inactivation of p53 by mutation, or by its interactions with oncogene products of DNA tumour viruses, can lead to cancer. These mutations seem to be the most common genetic change in human cancers.Entities:
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Year: 1991 PMID： 2046748 DOI： 10.1038/351453a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962