Literature DB >> 20161272

An amine-derivatized, DOTA-loaded polymeric support for Fmoc Solid Phase Peptide Synthesis.

Byunghee Yoo1, Vipul R Sheth, Mark D Pagel.   

Abstract

An amine-derivatized DOTA has been used to modify the surface of a polymeric support for conventional Solid Phase Peptide Synthesis (SPPS) following standard Fmoc chemistry methods. This methodology was used to synthesize a peptide-DOTA conjugate that was demonstrated to be a PARACEST MRI contrast agent. Therefore, this synthesis methodology can facilitate Fmoc SPPS of molecular imaging contrast agents.

Entities:  

Year:  2009        PMID： 20161272      PMCID： PMC2702766          DOI： 10.1016/j.tetlet.2009.05.061

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  17 in total

1.  An improved method for conjugating monoclonal antibodies with N-hydroxysulfosuccinimidyl DOTA.

Authors:  M R Lewis; J Y Kao; A L Anderson; J E Shively; A Raubitschek
Journal:  Bioconjug Chem       Date:  2001 Mar-Apr       Impact factor: 4.774

Review 2.  PARACEST agents: modulating MRI contrast via water proton exchange.

Authors:  Shanrong Zhang; Matthew Merritt; Donald E Woessner; Robert E Lenkinski; A Dean Sherry
Journal:  Acc Chem Res       Date:  2003-10       Impact factor: 22.384

3.  The monitoring of reactions in solid-phase peptide synthesis with picric acid.

Authors:  B F Gisin
Journal:  Anal Chim Acta       Date:  1972-01       Impact factor: 6.558

4.  Zinc-promoted simple synthesis of oligomer-free N(alpha)-Fmoc-amino acids using Fmoc-Cl as an acylating agent under neutral conditions.

Authors:  H N Gopi; V V Suresh Babu
Journal:  J Pept Res       Date:  2000-04

Review 5.  PET (positron emission tomography) imaging of biomolecules using metal-DOTA complexes: a new collaborative challenge by chemists, biologists, and physicians for future diagnostics and exploration of in vivo dynamics.

Authors:  Katsunori Tanaka; Koichi Fukase
Journal:  Org Biomol Chem       Date:  2008-02-01       Impact factor: 3.876

6.  Solid-phase synthesis of DOTA-peptides.

Authors:  Luis M De León-Rodriguez; Zoltan Kovacs; Gregg R Dieckmann; A Dean Sherry
Journal:  Chemistry       Date:  2004-03-05       Impact factor: 5.236

Review 7.  The synthesis and chelation chemistry of DOTA-peptide conjugates.

Authors:  Luis M De León-Rodríguez; Zoltan Kovacs
Journal:  Bioconjug Chem       Date:  2007-12-12       Impact factor: 4.774

Review 8.  From combinatorial chemistry to cancer-targeting peptides.

Authors:  Olulanu H Aina; Ruiwu Liu; Julie L Sutcliffe; Jan Marik; Chong-Xian Pan; Kit S Lam
Journal:  Mol Pharm       Date:  2007-09-20       Impact factor: 4.939

9.  On-resin assembly of a linkerless lanthanide(III)-based luminescence label and its application to the total synthesis of site-specifically labeled mechanosensitive channels.

Authors:  Christian F W Becker; Daniel Clayton; George Shapovalov; Henry A Lester; Gerd G Kochendoerfer
Journal:  Bioconjug Chem       Date:  2004 Sep-Oct       Impact factor: 4.774

10.  Cell surface antigens in renal tumour cells: detection by immunoluminescence and enzymatic analysis.

Authors:  F Laube; B Göhring; H Sann; I Willhardt
Journal:  Br J Cancer       Date:  2001-09-14       Impact factor: 7.640
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  12 in total

1.  On the Synthesis of 1,4,7-Tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane.

Authors:  Bhumasamudram Jagadish; Gayle L Brickert-Albrecht; Gary S Nichol; Eugene A Mash; Natarajan Raghunand
Journal:  Tetrahedron Lett       Date:  2011-04-27       Impact factor: 2.415

2.  Strategies for the preparation of bifunctional gadolinium(III) chelators.

Authors:  Luca Frullano; Peter Caravan
Journal:  Curr Org Synth       Date:  2011-08-01       Impact factor: 1.975

3.  Fluorescent and lanthanide labeling for ligand screens, assays, and imaging.

Authors:  Jatinder S Josan; Channa R De Silva; Byunghee Yoo; Ronald M Lynch; Mark D Pagel; Josef Vagner; Victor J Hruby
Journal:  Methods Mol Biol       Date:  2011

4.  A CatalyCEST MRI Contrast Agent that Can Simultaneously Detect Two Enzyme Activities.

Authors:  Gabriela Fernández-Cuervo; Sanhita Sinharay; Mark D Pagel
Journal:  Chembiochem       Date:  2016-02-03       Impact factor: 3.164

Review 5.  A review of responsive MRI contrast agents: 2005-2014.

Authors:  Dina V Hingorani; Adam S Bernstein; Mark D Pagel
Journal:  Contrast Media Mol Imaging       Date:  2014-10-29       Impact factor: 3.161

Review 6.  Detecting enzyme activities with exogenous MRI contrast agents.

Authors:  Dina V Hingorani; Byunghee Yoo; Adam S Bernstein; Mark D Pagel
Journal:  Chemistry       Date:  2014-07-02       Impact factor: 5.236

7.  Diamagnetic Imaging Agents with a Modular Chemical Design for Quantitative Detection of β-Galactosidase and β-Glucuronidase Activities with CatalyCEST MRI.

Authors:  Gabriela Fernández-Cuervo; Kirsten A Tucker; Scott W Malm; Kyle M Jones; Mark D Pagel
Journal:  Bioconjug Chem       Date:  2016-10-06       Impact factor: 4.774

8.  A catalyCEST MRI contrast agent that detects the enzyme-catalyzed creation of a covalent bond.

Authors:  Dina V Hingorani; Edward A Randtke; Mark D Pagel
Journal:  J Am Chem Soc       Date:  2013-04-23       Impact factor: 15.419

9.  A single diamagnetic catalyCEST MRI contrast agent that detects cathepsin B enzyme activity by using a ratio of two CEST signals.

Authors:  Dina V Hingorani; Luis A Montano; Edward A Randtke; Yeon Sun Lee; Julio Cárdenas-Rodríguez; Mark D Pagel
Journal:  Contrast Media Mol Imaging       Date:  2015-12-03       Impact factor: 3.161

10.  Noninvasive detection of enzyme activity in tumor models of human ovarian cancer using catalyCEST MRI.

Authors:  Sanhita Sinharay; Edward A Randtke; Kyle M Jones; Christine M Howison; Setsuko K Chambers; Hisataka Kobayashi; Mark D Pagel
Journal:  Magn Reson Med       Date:  2016-05-25       Impact factor: 4.668
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