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Literature DB >> 20160970

Synthesis of α-carboranyl-α-acyloxy-amides as potential BNCT agents.

Subash C Jonnalagadda¹, Jonathan S Cruz, Ryan J Connell, Patricia M Scott, Venkatram R Mereddy.

Abstract

Novel α-carboranyl-α-acyloxy-amides were prepared as potential BNCT agents utilizing three component Passerini reaction. Preliminary cytotoxicity of the representative compounds on two brain tumor cell lines (U-87 and A-172) showed no effect on cell viability; an essential requirement for utility as potential BNCT agents.

Entities: Chemical Disease Gene Species

Year: 2009 PMID： 20160970 PMCID： PMC2760853 DOI： 10.1016/j.tetlet.2009.05.026

Source DB: PubMed Journal: Tetrahedron Lett ISSN： 0040-4039 Impact factor: 2.415

16 in total

1. The Chemistry of Neutron Capture Therapy.

Authors: Albert H. Soloway; Werner Tjarks; Beverly A. Barnum; Feng-Guang Rong; Rolf F. Barth; Iwona M. Codogni; J. Gerald Wilson
Journal: Chem Rev Date: 1998-06-18 Impact factor: 60.622

2. Synthesis of functionalized carboranes as potential anticancer and BNCT agents.

Authors: Venkata Jaganmohan Reddy; Matthew M Roforth; Chalet Tan; M Venkat Ram Reddy
Journal: Inorg Chem Date: 2007-01-22 Impact factor: 5.165

3. Synthesis, preformulation and liposomal formulation of cholesteryl carborane esters with various fatty chains.

Authors: Fars Alanazi; Hengguang Li; David S Halpern; Svein Øie; D Robert Lu
Journal: Int J Pharm Date: 2003-04-14 Impact factor: 5.875

4. Synthesis of boron cluster lipids: closo-dodecaborate as an alternative hydrophilic function of boronated liposomes for neutron capture therapy.

Authors: Jong-Dae Lee; Manabu Ueno; Yusuke Miyajima; Hiroyuki Nakamura
Journal: Org Lett Date: 2007-01-18 Impact factor: 6.005

Review 5. Boron neutron capture therapy of cancer: current status and future prospects.

Authors: Rolf F Barth; Jeffrey A Coderre; M Graça H Vicente; Thomas E Blue
Journal: Clin Cancer Res Date: 2005-06-01 Impact factor: 12.531

6. Human glioblastoma cell lines: levels of low-density lipoprotein receptor and low-density lipoprotein receptor-related protein.

Authors: L Maletínská; E A Blakely; K A Bjornstad; D F Deen; L J Knoff; T M Forte
Journal: Cancer Res Date: 2000-04-15 Impact factor: 12.701

Synthesis of α-carboranyl-α-acyloxy-amides as potential BNCT agents.

1. The Chemistry of Neutron Capture Therapy.

2. Synthesis of functionalized carboranes as potential anticancer and BNCT agents.

3. Synthesis, preformulation and liposomal formulation of cholesteryl carborane esters with various fatty chains.

4. Synthesis of boron cluster lipids: closo-dodecaborate as an alternative hydrophilic function of boronated liposomes for neutron capture therapy.

Review 5. Boron neutron capture therapy of cancer: current status and future prospects.

6. Human glioblastoma cell lines: levels of low-density lipoprotein receptor and low-density lipoprotein receptor-related protein.

7. Catalytic phenylborylation reaction by iridium(0) nanoparticles produced from hydridoiridium carborane.

Review 8. Boron containing macromolecules and nanovehicles as delivery agents for neutron capture therapy.

Review 9. Antibody-modified liposomes for cancer chemotherapy.

10. In vitro uptake of a new cholesteryl carborane ester compound by human glioma cell lines.

1. Synthesis and evaluation of functionalized benzoboroxoles as potential anti-tuberculosis agents.

2. Therapeutic potential of atmospheric neutrons.