Vladimir Torchilin1. 1. Center for Pharmaceutical Biotechnology and Nanomedicine, Department of Pharmaceutical Sciences, Northeastern University, Boston, MA 02115, USA. v.torchilin@neu.edu
Abstract
BACKGROUND: Liposomes, phospholipids, nanosized bubbles with a bilayered membrane structure, have drawn a lot of interest as pharmaceutical carriers for drugs and genes. In particular, liposomes are widely used for drug delivery into tumors. OBJECTIVE: In many cases, to enhance the efficacy of the liposomal drugs, drug-loaded liposomes are targeted to the tumors by means of different specific ligands, such as monoclonal antibodies. Thus, this review analyzes the application of antibody-targeted liposomes loaded with various chemotherapeutic agents and various liposomal products under development at experimental and preclinical level. METHODS: The papers published on the subject of cancer-targeted liposomes mainly over the last 10 - 15 years are discussed. CONCLUSION: Antibody-targeted liposomes loaded with anticancer drugs demonstrate high potential for clinical applications.
BACKGROUND: Liposomes, phospholipids, nanosized bubbles with a bilayered membrane structure, have drawn a lot of interest as pharmaceutical carriers for drugs and genes. In particular, liposomes are widely used for drug delivery into tumors. OBJECTIVE: In many cases, to enhance the efficacy of the liposomal drugs, drug-loaded liposomes are targeted to the tumors by means of different specific ligands, such as monoclonal antibodies. Thus, this review analyzes the application of antibody-targeted liposomes loaded with various chemotherapeutic agents and various liposomal products under development at experimental and preclinical level. METHODS: The papers published on the subject of cancer-targeted liposomes mainly over the last 10 - 15 years are discussed. CONCLUSION: Antibody-targeted liposomes loaded with anticancer drugs demonstrate high potential for clinical applications.
Authors: Rajiv Kumar; Tymish Y Ohulchanskyy; Indrajit Roy; Sandesh K Gupta; Carsten Borek; Mark E Thompson; Paras N Prasad Journal: ACS Appl Mater Interfaces Date: 2009-07 Impact factor: 9.229
Authors: Xi Li; Hongyu Zhou; Lei Yang; Guoqing Du; Atmaram S Pai-Panandiker; Xuefei Huang; Bing Yan Journal: Biomaterials Date: 2011-01-12 Impact factor: 12.479
Authors: Subash C Jonnalagadda; Jonathan S Cruz; Ryan J Connell; Patricia M Scott; Venkatram R Mereddy Journal: Tetrahedron Lett Date: 2009-07-29 Impact factor: 2.415