BACKGROUND: The study was conducted to examine the impact of oral contraceptives (OCs) on serum antimullerian hormone (AMH) levels by obesity status in reproductive-age women. STUDY DESIGN: Ovulatory women, ages 18-35 years, of normal (<25 kg/m(2); n=10) and obese (>30 kg/m(2); n=10) body mass index (BMI) received a low-dose OC (20 mcg ethinyl estradiol/100 mcg levonorgestrel) for two cycles. Serum samples obtained at several time points during active pill use and hormone-free intervals were analyzed for AMH, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol and inhibin B. RESULTS: AMH levels did not differ by OC cycle day in either BMI group. On average, AMH levels were 34% lower in the obese group (2.9+/-2.1 vs. 4.4+/-1.8 ng/mL, p<.05). Modeling to determine differences in AMH throughout the cycle based on obesity status demonstrated significantly lower levels (p<.05), whereas serum AMH, FSH, LH, estradiol and inhibin B levels revealed no correlations when all time points were included. CONCLUSIONS: In reproductive-age women, serum AMH levels do not appear to fluctuate during OC use, but AMH levels are significantly lower in obese women. Lower levels do not appear to be due to differences in gonadotropin levels or ovarian activity. Copyright (c) 2010 Elsevier Inc. All rights reserved.
BACKGROUND: The study was conducted to examine the impact of oral contraceptives (OCs) on serum antimullerian hormone (AMH) levels by obesity status in reproductive-age women. STUDY DESIGN: Ovulatory women, ages 18-35 years, of normal (<25 kg/m(2); n=10) and obese (>30 kg/m(2); n=10) body mass index (BMI) received a low-dose OC (20 mcg ethinyl estradiol/100 mcg levonorgestrel) for two cycles. Serum samples obtained at several time points during active pill use and hormone-free intervals were analyzed for AMH, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol and inhibin B. RESULTS:AMH levels did not differ by OC cycle day in either BMI group. On average, AMH levels were 34% lower in the obese group (2.9+/-2.1 vs. 4.4+/-1.8 ng/mL, p<.05). Modeling to determine differences in AMH throughout the cycle based on obesity status demonstrated significantly lower levels (p<.05), whereas serum AMH, FSH, LH, estradiol and inhibin B levels revealed no correlations when all time points were included. CONCLUSIONS: In reproductive-age women, serum AMH levels do not appear to fluctuate during OC use, but AMH levels are significantly lower in obesewomen. Lower levels do not appear to be due to differences in gonadotropin levels or ovarian activity. Copyright (c) 2010 Elsevier Inc. All rights reserved.
Authors: I A J van Rooij; F J M Broekmans; E R te Velde; B C J M Fauser; L F J M M Bancsi; F H de Jong; A P N Themmen Journal: Hum Reprod Date: 2002-12 Impact factor: 6.918
Authors: Wouter J K Hehenkamp; Caspar W N Looman; Axel P N Themmen; Frank H de Jong; E R Te Velde; Frank J M Broekmans Journal: J Clin Endocrinol Metab Date: 2006-06-27 Impact factor: 5.958
Authors: Sandra Ledoux; Danila B Campos; Flavia L Lopes; Mira Dobias-Goff; Marie-France Palin; Bruce D Murphy Journal: Endocrinology Date: 2006-08-17 Impact factor: 4.736
Authors: Y Arita; S Kihara; N Ouchi; M Takahashi; K Maeda; J Miyagawa; K Hotta; I Shimomura; T Nakamura; K Miyaoka; H Kuriyama; M Nishida; S Yamashita; K Okubo; K Matsubara; M Muraguchi; Y Ohmoto; T Funahashi; Y Matsuzawa Journal: Biochem Biophys Res Commun Date: 1999-04-02 Impact factor: 3.575
Authors: Ilse A J van Rooij; Frank J M Broekmans; Gabrielle J Scheffer; Caspar W N Looman; J Dik F Habbema; Frank H de Jong; Bart J C M Fauser; Axel P N Themmen; Egbert R te Velde Journal: Fertil Steril Date: 2005-04 Impact factor: 7.329
Authors: Alison B Edelman; Nichole E Carlson; Ganesh Cherala; Myrna Y Munar; Richard L Stouffer; Judy L Cameron; Frank Z Stanczyk; Jeffrey T Jensen Journal: Contraception Date: 2009-06-04 Impact factor: 3.375
Authors: Rebecca Scherzer; Peter Bacchetti; Geralyn Messerlian; Johanna Goderre; Pauline M Maki; David B Seifer; Kathryn Anastos; Roksana Karim; Ruth M Greenblatt Journal: Am J Reprod Immunol Date: 2014-10-23 Impact factor: 3.886
Authors: Lia A Bernardi; Mercedes R Carnethon; Peter J de Chavez; Deborah E Ikhena; Lisa M Neff; Donna D Baird; Erica E Marsh Journal: Obesity (Silver Spring) Date: 2016-12-07 Impact factor: 5.002
Authors: Christiana M Shaw; Frank Z Stanczyk; Brian L Egleston; L L Kahle; Cynthia S Spittle; Andrew K Godwin; Louise A Brinton; Joanne F Dorgan Journal: Fertil Steril Date: 2011-06-30 Impact factor: 7.329
Authors: Ellen M Mikkelsen; Anders H Riis; Lauren A Wise; Elizabeth E Hatch; Kenneth J Rothman; Henrik Toft Sørensen Journal: Hum Reprod Date: 2013-02-20 Impact factor: 6.918
Authors: Kimberly A Bertrand; Heather J Baer; E John Orav; Catherine Klifa; Ajay Kumar; Nola M Hylton; Erin S LeBlanc; Linda G Snetselaar; Linda Van Horn; Joanne F Dorgan Journal: Cancer Epidemiol Biomarkers Prev Date: 2016-05-09 Impact factor: 4.254
Authors: Lauren W Roth; Amanda A Allshouse; Erica L Bradshaw-Pierce; Jennifer Lesh; Justin Chosich; Wendy Kohrt; Andrew P Bradford; Alex J Polotsky; Nanette Santoro Journal: Clin Endocrinol (Oxf) Date: 2014-03-20 Impact factor: 3.478