Literature DB >> 20153644

Bisleuconothine A, an eburnane-aspidosperma bisindole alkaloid from Leuconotis griffithii.

Yusuke Hirasawa1, Tomokazu Shoji, Takashi Arai, Alfarius E Nugroho, Jun Deguchi, Takahiro Hosoya, Nahoko Uchiyama, Yukihiro Goda, Khalijah Awang, A Hamid A Hadi, Motoo Shiro, Hiroshi Morita.   

Abstract

A new bisindole alkaloid, bisleuconothine A (1) consisting of an eburnane-aspidosperma type skeleton, was isolated from the bark of Leuconotis griffithii. The structure including absolute stereochemistry was elucidated on the basis of 2D NMR data and X-ray analysis. Bisleuconothine A (1) showed cell growth inhibitory activity against various human cancer cell lines. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20153644     DOI： 10.1016/j.bmcl.2010.01.051

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  5 in total

1.  Haworforbins A-C, new phenolics from Haworthia cymbiformis.

Authors:  Fumie Yamasaki; Shoko Machida; Asami Nakata; Alfarius Eko Nugroho; Yusuke Hirasawa; Toshio Kaneda; Osamu Shirota; Naoyuki Hagane; Tadayoshi Sugizaki; Hiroshi Morita
Journal:  J Nat Med       Date:  2012-03-16       Impact factor: 2.343

2.  Leucophyllinines A and B, bisindole alkaloids from Leuconotis eugeniifolia.

Authors:  Yiming Tang; Alfarius Eko Nugroho; Yusuke Hirasawa; Takahiro Tougan; Toshihiro Horii; A Hamid A Hadi; Hiroshi Morita
Journal:  J Nat Med       Date:  2019-03-25       Impact factor: 2.343

3.  Reinereins A and B, new onocerane triterpenoids from Reinwardtiodendron cinereum.

Authors:  Alfarius Eko Nugroho; Daisuke Inoue; Chin Piow Wong; Yusuke Hirasawa; Toshio Kaneda; Osamu Shirota; A Hamid A Hadi; Hiroshi Morita
Journal:  J Nat Med       Date:  2018-02-16       Impact factor: 2.343

4.  Stereocontrolled Synthesis of (±)-Melokhanine E via an Intramolecular Formal [3 + 2] Cycloaddition.

Authors:  Anna E Cholewczynski; Peyton C Williams; Joshua G Pierce
Journal:  Org Lett       Date:  2020-01-07       Impact factor: 6.005

5.  Bisleuconothine A, a bisindole alkaloid, inhibits colorectal cancer cell in vitro and in vivo targeting Wnt signaling.

Authors:  Ling-Mei Kong; Tao Feng; Yuan-Yuan Wang; Xing-Yao Li; Zhen-Nan Ye; Tao An; Chen Qing; Xiao-Dong Luo; Yan Li
Journal:  Oncotarget       Date:  2016-03-01
  5 in total

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