Literature DB >> 2014981

Delta pH-dependent accumulation of tetracycline in Escherichia coli.

A Yamaguchi1, H Ohmori, M Kaneko-Ohdera, T Nomura, T Sawai.   

Abstract

The effects of ionophores on tetracycline accumulation in Escherichia coli cells were investigated in the presence of polymyxin B nonapeptide. Accumulation was inhibited by nigericin but not by valinomycin. Tetracycline accumulation was stimulated by decreasing the pH of the medium and inhibited by the addition of magnesium ions. These results indicated that tetracycline enters cells through diffusion as a protonated form (TH2) and is accumulated as a membrane-impermeable magnesium-tetracycline chelate complex (THMg+). This noncarrier diffusion hypothesis was confirmed by the fact that tetracycline accumulated in protein-free liposomes through an artificially imposed pH difference.

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Year:  1991        PMID： 2014981      PMCID： PMC244940          DOI： 10.1128/AAC.35.1.53

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  20 in total

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Journal:  Antimicrob Agents Chemother       Date:  1978-08       Impact factor: 5.191

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Authors:  I Chopra; P Ball
Journal:  Adv Microb Physiol       Date:  1982       Impact factor: 3.517

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Authors:  P W Flatman
Journal:  J Membr Biol       Date:  1984       Impact factor: 1.843

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Authors:  A Yamaguchi; T Udagawa; T Sawai
Journal:  J Biol Chem       Date:  1990-03-25       Impact factor: 5.157

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Authors:  E V Lindley; G R Munske; J A Magnuson
Journal:  J Bacteriol       Date:  1984-04       Impact factor: 3.490

8.  Energetics of tetracycline transport into Escherichia coli.

Authors:  M C Smith; I Chopra
Journal:  Antimicrob Agents Chemother       Date:  1984-04       Impact factor: 5.191

9.  Streptococcus faecalis proton gradients and tetracycline transport.

Authors:  G R Munske; E V Lindley; J A Magnuson
Journal:  J Bacteriol       Date:  1984-04       Impact factor: 3.490

10.  Polycations sensitize enteric bacteria to antibiotics.

Authors:  M Vaara; T Vaara
Journal:  Antimicrob Agents Chemother       Date:  1983-07       Impact factor: 5.191
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  28 in total

Review 1.  Agents that increase the permeability of the outer membrane.

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Journal:  Microbiol Rev       Date:  1992-09

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Authors:  Linda Ejim; Maya A Farha; Shannon B Falconer; Jan Wildenhain; Brian K Coombes; Mike Tyers; Eric D Brown; Gerard D Wright
Journal:  Nat Chem Biol       Date:  2011-04-24       Impact factor: 15.040

3.  L-lysine potentiates aminoglycosides against Acinetobacter baumannii via regulation of proton motive force and antibiotics uptake.

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Authors:  Ronald Domalaon; Temilolu Idowu; George G Zhanel; Frank Schweizer
Journal:  Clin Microbiol Rev       Date:  2018-03-14       Impact factor: 26.132

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Authors:  J Cheng; D B Hicks; T A Krulwich
Journal:  Proc Natl Acad Sci U S A       Date:  1996-12-10       Impact factor: 11.205

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Authors:  H Nikaido; D G Thanassi
Journal:  Antimicrob Agents Chemother       Date:  1993-07       Impact factor: 5.191

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Authors:  L M Hansen; L M McMurry; S B Levy; D C Hirsh
Journal:  Antimicrob Agents Chemother       Date:  1993-12       Impact factor: 5.191

Review 8.  Tetracycline Antibiotics and Resistance.

Authors:  Trudy H Grossman
Journal:  Cold Spring Harb Perspect Med       Date:  2016-04-01       Impact factor: 6.915

9.  Na+/H+ antiport activity conferred by Bacillus subtilis tetA(L), a 5' truncation product of tetA(L), and related plasmid genes upon Escherichia coli.

Authors:  J Cheng; K Baldwin; A A Guffanti; T A Krulwich
Journal:  Antimicrob Agents Chemother       Date:  1996-04       Impact factor: 5.191

10.  Iron blocks the accumulation and activity of tetracyclines in bacteria.

Authors:  Angela M Avery; Helen J Goddard; Edward R Sumner; Simon V Avery
Journal:  Antimicrob Agents Chemother       Date:  2004-05       Impact factor: 5.191
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