Literature DB >> 21516114

Combinations of antibiotics and nonantibiotic drugs enhance antimicrobial efficacy.

Linda Ejim1, Maya A Farha, Shannon B Falconer, Jan Wildenhain, Brian K Coombes, Mike Tyers, Eric D Brown, Gerard D Wright.   

Abstract

Combinations of antibiotics are commonly used in medicine to broaden antimicrobial spectrum and generate synergistic effects. Alternatively, combination of nonantibiotic drugs with antibiotics offers an opportunity to sample a previously untapped expanse of bioactive chemical space. We screened a collection of drugs to identify compounds that augment the activity of the antibiotic minocycline. Unexpected synergistic drug combinations exhibited in vitro and in vivo activity against bacterial pathogens, including multidrug-resistant isolates.

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Year:  2011        PMID： 21516114     DOI： 10.1038/nchembio.559

Source DB:  PubMed          Journal:  Nat Chem Biol        ISSN： 1552-4450            Impact factor:   15.040


  23 in total

1.  Proton motive force drives the interaction of the inner membrane TolA and outer membrane pal proteins in Escherichia coli.

Authors:  E Cascales; M Gavioli; J N Sturgis; R Lloubès
Journal:  Mol Microbiol       Date:  2000-11       Impact factor: 3.501

Review 2.  From large networks to small molecules.

Authors:  Jeffrey R Sharom; David S Bellows; Mike Tyers
Journal:  Curr Opin Chem Biol       Date:  2004-02       Impact factor: 8.822

Review 3.  Bacterial uptake of aminoglycoside antibiotics.

Authors:  H W Taber; J P Mueller; P F Miller; A S Arrow
Journal:  Microbiol Rev       Date:  1987-12

4.  Pretreatment of mice with streptomycin provides a Salmonella enterica serovar Typhimurium colitis model that allows analysis of both pathogen and host.

Authors:  Manja Barthel; Siegfried Hapfelmeier; Leticia Quintanilla-Martínez; Marcus Kremer; Manfred Rohde; Michael Hogardt; Klaus Pfeffer; Holger Rüssmann; Wolf-Dietrich Hardt
Journal:  Infect Immun       Date:  2003-05       Impact factor: 3.441

Review 5.  Reversal of resistance in microorganisms by help of non-antibiotics.

Authors:  Jette E Kristiansen; Oliver Hendricks; Thomas Delvin; Trine S Butterworth; Lone Aagaard; Jørn B Christensen; Vivian C Flores; Hendrik Keyzer
Journal:  J Antimicrob Chemother       Date:  2007-04-02       Impact factor: 5.790

6.  Promethazine renders Escherichia coli susceptible to penicillin G: real-time measurement of bacterial susceptibility by fluoro-luminometry.

Authors:  Janne Lehtinen; Esa-Matti Lilius
Journal:  Int J Antimicrob Agents       Date:  2007-05-01       Impact factor: 5.283

7.  The genetic landscape of a cell.

Authors:  Michael Costanzo; Anastasia Baryshnikova; Jeremy Bellay; Yungil Kim; Eric D Spear; Carolyn S Sevier; Huiming Ding; Judice L Y Koh; Kiana Toufighi; Sara Mostafavi; Jeany Prinz; Robert P St Onge; Benjamin VanderSluis; Taras Makhnevych; Franco J Vizeacoumar; Solmaz Alizadeh; Sondra Bahr; Renee L Brost; Yiqun Chen; Murat Cokol; Raamesh Deshpande; Zhijian Li; Zhen-Yuan Lin; Wendy Liang; Michaela Marback; Jadine Paw; Bryan-Joseph San Luis; Ermira Shuteriqi; Amy Hin Yan Tong; Nydia van Dyk; Iain M Wallace; Joseph A Whitney; Matthew T Weirauch; Guoqing Zhong; Hongwei Zhu; Walid A Houry; Michael Brudno; Sasan Ragibizadeh; Balázs Papp; Csaba Pál; Frederick P Roth; Guri Giaever; Corey Nislow; Olga G Troyanskaya; Howard Bussey; Gary D Bader; Anne-Claude Gingras; Quaid D Morris; Philip M Kim; Chris A Kaiser; Chad L Myers; Brenda J Andrews; Charles Boone
Journal:  Science       Date:  2010-01-22       Impact factor: 47.728

Review 8.  The anti-inflammatory non-antibiotic helper compound diclofenac: an antibacterial drug target.

Authors:  K Mazumdar; S G Dastidar; J H Park; N K Dutta
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2009-04-28       Impact factor: 3.267

9.  Effects of tetracyclines on the production of extracellular proteins by members of the propionibacteriaceae.

Authors:  I Chopra; K Hacker
Journal:  FEMS Microbiol Lett       Date:  1989-07-01       Impact factor: 2.742

10.  Chemical combination effects predict connectivity in biological systems.

Authors:  Joseph Lehár; Grant R Zimmermann; Andrew S Krueger; Raymond A Molnar; Jebediah T Ledell; Adrian M Heilbut; Glenn F Short; Leanne C Giusti; Garry P Nolan; Omar A Magid; Margaret S Lee; Alexis A Borisy; Brent R Stockwell; Curtis T Keith
Journal:  Mol Syst Biol       Date:  2007-02-27       Impact factor: 11.429
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  149 in total

Review 1.  Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?

Authors:  David Brown
Journal:  Nat Rev Drug Discov       Date:  2015-10-23       Impact factor: 84.694

Review 2.  Multidrug evolutionary strategies to reverse antibiotic resistance.

Authors:  Michael Baym; Laura K Stone; Roy Kishony
Journal:  Science       Date:  2016-01-01       Impact factor: 47.728

Review 3.  Antibacterial drug discovery in the resistance era.

Authors:  Eric D Brown; Gerard D Wright
Journal:  Nature       Date:  2016-01-21       Impact factor: 49.962

4.  Structure-guided optimization of protein kinase inhibitors reverses aminoglycoside antibiotic resistance.

Authors:  Peter J Stogios; Peter Spanogiannopoulos; Elena Evdokimova; Olga Egorova; Tushar Shakya; Nick Todorovic; Alfredo Capretta; Gerard D Wright; Alexei Savchenko
Journal:  Biochem J       Date:  2013-09-01       Impact factor: 3.857

5.  Minocycline attenuates HIV-1 infection and suppresses chronic immune activation in humanized NOD/LtsZ-scidIL-2Rγ(null) mice.

Authors:  Maneesh Singh; Pratibha Singh; Dolores Vaira; Mathieu Amand; Souad Rahmouni; Michel Moutschen
Journal:  Immunology       Date:  2014-08       Impact factor: 7.397

6.  Combinatorial drug discovery in nanoliter droplets.

Authors:  Anthony Kulesa; Jared Kehe; Juan E Hurtado; Prianca Tawde; Paul C Blainey
Journal:  Proc Natl Acad Sci U S A       Date:  2018-06-13       Impact factor: 11.205

7.  A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance.

Authors:  Benjamin M Vincent; Jean-Baptiste Langlois; Raja Srinivas; Alex K Lancaster; Ruth Scherz-Shouval; Luke Whitesell; Bruce Tidor; Stephen L Buchwald; Susan Lindquist
Journal:  Cell Chem Biol       Date:  2016-08-11       Impact factor: 8.116

8.  New life for an old drug: the anthelmintic drug niclosamide inhibits Pseudomonas aeruginosa quorum sensing.

Authors:  Francesco Imperi; Francesco Massai; Cejoice Ramachandran Pillai; Francesca Longo; Elisabetta Zennaro; Giordano Rampioni; Paolo Visca; Livia Leoni
Journal:  Antimicrob Agents Chemother       Date:  2012-12-17       Impact factor: 5.191

9.  Inhibitors of bacterial tubulin target bacterial membranes in vivo.

Authors:  Marie H Foss; Ye-Jin Eun; Charles I Grove; Daniel A Pauw; Nohemy A Sorto; Jarred W Rensvold; David J Pagliarini; Jared T Shaw; Douglas B Weibel
Journal:  Medchemcomm       Date:  2012-07-18       Impact factor: 3.597

10.  A High-Throughput Approach To Identify Compounds That Impair Envelope Integrity in Escherichia coli.

Authors:  Kristin R Baker; Bimal Jana; Henrik Franzyk; Luca Guardabassi
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191
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