| Literature DB >> 2014262 |
R J Rotello1, R C Lieberman, A F Purchio, L E Gerschenson.
Abstract
Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.Entities:
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Year: 1991 PMID: 2014262 PMCID: PMC51457 DOI: 10.1073/pnas.88.8.3412
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN: 0027-8424 Impact factor: 11.205