Literature DB >> 2014262

Coordinated regulation of apoptosis and cell proliferation by transforming growth factor beta 1 in cultured uterine epithelial cells.

R J Rotello1, R C Lieberman, A F Purchio, L E Gerschenson.   

Abstract

Cell and tissue growth is regulated through a complex interplay of stimulatory and inhibitory signals. We describe two biological actions of transforming growth factor beta 1 (TGF-beta 1) in primary cultures of rabbit uterine epithelial cells: (i) inhibition of cell proliferation and (ii) a concomitant increase in cells undergoing apoptosis (programmed cell death). It is proposed that proliferation and apoptosis together comprise normal cell growth regulation.

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Year:  1991        PMID: 2014262      PMCID: PMC51457          DOI: 10.1073/pnas.88.8.3412

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN: 0027-8424            Impact factor:   11.205


  28 in total

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  45 in total

Review 1.  Hormonal regulation of physiological cell turnover and apoptosis.

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Authors:  Shara N Pantry; Peter G Medveczky
Journal:  Semin Cancer Biol       Date:  2009-02-21       Impact factor: 15.707

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10.  Role of mesenchymal cell death in lung remodeling after injury.

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Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

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