| Literature DB >> 20141833 |
Monica Ransom1, Briana K Dennehey, Jessica K Tyler.
Abstract
Nuclear DNA is tightly packaged into chromatin, which profoundly influences DNA replication, transcription, repair, and recombination. The extensive interactions between the basic histone proteins and acidic DNA make the nucleosomal unit of chromatin a highly stable entity. For the cellular machinery to access the DNA, the chromatin must be unwound and the DNA cleared of histone proteins. Conversely, the DNA has to be repackaged into chromatin afterward. This review focuses on the roles of the histone chaperones in assembling and disassembling chromatin during the processes of DNA replication and repair. Copyright 2010 Elsevier Inc. All rights reserved.Entities:
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Year: 2010 PMID： 20141833 PMCID： PMC3433953 DOI： 10.1016/j.cell.2010.01.004
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582