Perineal descent and patients' symptoms of anorectal dysfunction, pelvic organ prolapse, and urinary incontinence.

INTRODUCTION AND HYPOTHESIS: The aim of this dynamic magnetic resonance (MR) imaging study was to assess the relation between the position and mobility of the perineum and patients' symptoms of pelvic floor dysfunction.
METHODS: Patients' symptoms were measured with the use of validated questionnaires. Univariate logistic regression analyses were used to study the relationship between the questionnaires domain scores and the perineal position on dynamic MR imaging, as well as baseline characteristics (age, body mass index, and parity).
RESULTS: Sixty-nine women were included in the analysis. Only the domain score genital prolapse was associated with the perineal position on dynamic MR imaging. This association was strongest at rest.
CONCLUSIONS: Pelvic organ prolapse symptoms were associated with the degree of descent of the perineum on dynamic MR imaging. Perineal descent was not related to anorectal and/or urinary incontinence symptoms.

Introduction

The descending perineum syndrome was first described in 1966 by Parks et al. [1]. Typically, the syndrome is described as ballooning of the perineum several centimeters below the bony outlet of the pelvis during strain, although descent can also occur at rest.

One of the main causes is thought to be excessive and repetitive straining. This straining forces the anterior rectal wall to protrude into the anal canal and creates a sensation of incomplete defecation and weakness of the pelvic floor musculature. In turn, this causes more straining, and a vicious cycle is established [1, 2]. Other possible causes reported are weakness of the muscles of the pelvic floor caused by either the neuropathic degeneration of muscle that accompanies old age [3-5], or trauma to the pelvic floor muscles or their nerve supply during pregnancy and childbirth [4, 6, 7].

Abnormal perineal descent has been described in relation to a variety of anorectal disorders such as constipation, fecal incontinence, obstructed defecation, and rectal or pelvic pain. A systematic review of these clinical studies, however, did not show an association of perineal descent with constipation [8-10] and rectal or pelvic pain [10, 11], and the existing data on the association of perineal descent with fecal incontinence [9, 10, 12, 13] and obstructed defecation [14, 15] were conflicting. Only few papers have reported on the relation of perineal descent with symptoms of pelvic organ prolapse and stress urinary incontinence [11, 16, 17]. In these studies, prolapse symptoms seemed to be associated with the degree of perineal descent, whereas an association with stress urinary incontinence symptoms was unlikely.

In the urogynecological literature, perineal descent has not been extensively studied. The clinical implication of the condition and the relation to patients’ symptoms is still unknown. As a consequence, there is no consensus whether diagnosis and treatment of perineal descent should be done at all. The aim of this dynamic magnetic resonance (MR) imaging study was to assess the relation between the position and mobility of the perineum with patients’ symptoms of pelvic floor dysfunction using standardized questionnaires.

Materials and methods

This observational study was performed at the Radboud University Nijmegen Medical Centre, the Netherlands. The center is a national tertiary referral center for women with pelvic organ dysfunctions. The study period was from September 2005 through January 2008. Inclusion criteria were consecutive women with pelvic organ dysfunction who had dynamic MR imaging in the inclusion period and had returned the questionnaires Urogenital Distress Inventory (UDI) and Defecatory Distress Inventory (DDI). MR imaging was performed as part of routine clinical practice in patients with recurrent prolapse, especially in the posterior compartment, and in case the patient’s complaints did not correspond with clinical findings. In the Netherlands, the Working Party on Pelvic Floor and Urogynecology of the Dutch Society of Obstetrics and Gynecology recommends each urogynecological center to assess the presence and the bother of pelvic floor dysfunction by taking a careful history and use of the UDI and the DDI. These questionnaires are handed out to all patients with urogynecological symptoms during intake and are completed and returned immediately or by return envelope.

The study was submitted to and deemed exempt by the local institutional review board.

Symptom assessment

Patients’ symptoms were measured with use of the disease specific quality of life questionnaires UDI and DDI. The UDI questionnaire has previously been revised and has been validated for the Dutch language [18]. The original UDI domain structure was developed with data from a highly selective population of higher educated women, aged 45 years or older [19]. The revised UDI can be applied to a broad population of women, and is therefore recommended. This UDI consist of 11 items and five domains on bothersome urogenital symptoms (overactive bladder, urinary incontinence, obstructive micturition, pain, and genital prolapse). Two domains (urinary incontinence and genital prolapse) were used in the study, because only these two urogenital symptoms have been described in relation to perineal descent in the literature [11, 16, 17]. The DDI measures bothersome defecatory symptoms, and consists of 11 items in five domains (constipation, obstructive defecation, pain, incontinence, and flatulence). This questionnaire has been validated, however, has not yet been published. In Appendix A, the questions from the DDI to assess the presence of defecatory symptoms are presented.

Participants were asked whether or not a symptom was present, and in case present, the bother the woman experiences from that symptom. The latter is measured with a four-point Likert scale ranging from not at all to a lot. For factor analysis, the scores of both parts of each question were transformed into 1 = no symptom; 2 = symptom present, no bother; 3 = symptom present, slightly bothersome; 4 = symptom present, moderately bothersome; 5 = symptom present, greatly bothersome. In calculating domain scores, women not having a symptom or having a symptom without bother are scored equally. The domain scores were transformed into a continuous scale ranging from 0 to 100. A high score on the domain indicates more bothersome symptoms on that particular domain. Therefore, the scores represent both the presence and bother of the symptoms.

Dynamic MR imaging protocol [20–22]

The dynamic MR imaging was performed with the patient in the supine position with parallel and slightly flexed legs. Patients were requested not to void for 1-2 h prior to the examination. The rectum was opacified using 100-150 ml ultrasound gel. The urethra, bladder, and vagina were not opacified. No premedication was given. MR images were acquired using a 3 T MR scanner (TIM TRIO, Siemens Medical, Germany) and an eight-channel body phased-array coil. MR images were obtained in the midsagittal plane using a half-Fourier acquisition single-shot turbo spin-echo sequence (2000 ms/ 90 ms repetition time/ echo time; 1500 flip angle), with a temporal resolution of 1 s during 2 min. During the MR examination, the patient was asked to relax the pelvic floor muscles, to contract the muscles slowly, relax again, and then to increase the intra-abdominal pressure and strain in order to defecate. To assure that the patient followed the instruction given, all images were viewed online on the MR console. A whirl of urine in the bladder and/or a dent into the cranial portion of the bladder indicated adequate straining.

The images were analyzed at a later stage on a console with zoom facilities and electronic calipers. The observer was blinded to the patients’ symptoms and the clinical findings. The images on maximal strain were used to assess the prolapse.

The perineal position was determined as the perpendicular distance between the pubococcygeal line and the caudal margin of the sphincter ani muscle in centimeters, at rest and during maximal strain (Fig. 1) [17, 23]. The pubococcygeal line was defined as a straight line between the inferior rim of the pubic bone and the last visible coccygeal joint. Perineal mobility was assessed by calculating the difference between the position of the perineum during maximal strain and at rest. The intra- and interobserver reliability of these measurements have shown to be good to excellent, with the exception of the interobserver reliability at rest, which was moderate [20].

Fig. 1

MR image obtained at rest. Dynamic midsagittal half-Fourier acquisition single-shot turbo spin-echo (2000/90; 150°) through the pelvis of a 62-year-old woman with symptoms of pelvic organ prolapse. The image shows the measurement of the perineal position in relation to the reference line used. PCL pubococcygeal line

Statistical methods

In this study, the ability of MR imaging measurements to discriminate women with clear symptom from those with no or minor symptoms was assessed. For this purpose, the questionnaire domain scores were dichotomized as follows: ‘no and minor symptoms’ which are equal to: ‘no symptom’, ‘symptom present, no bother’ or ‘symptom present, slightly bothersome’ (domain score < 33.33) and ‘clear symptoms’ which are equal to: ‘symptom present, moderately bothersome’ or ‘symptom present, greatly bothersome’ (domain score ≥ 33.33), respectively.

Univariate logistic regression was used to study the relationship between the questionnaire domain scores and each of the measurements of the perineal position, (using MR imaging) and the baseline characteristics (i.e., age, BMI, and parity), separately. The dependent variable was the probability that an individual is classified into the highest coded category of a specific domain score (i.e., ‘clear symptoms’). The independent variable was one of the MR imaging measurements or one of the baseline characteristics, respectively. The crude odds ratios with 95% confidence intervals are presented.

Spearman’s rank correlation test was used to test the correlation between measurements of the perineal position and age, BMI, and parity for statistical significance. Statistical analyses were performed using SPSS version 16.0 (SPSS, Inc.,Chicago, IL, USA). P values < 0.05 were considered statistically significant.

Results

Overall, 700 new patients with urogynecological symptoms were evaluated during the study period. One hundred and twenty women underwent dynamic MR imaging of the pelvic floor. Sixty-nine of these women had completed the questionnaires and was included in the study. There were no statistically significant differences in baseline characteristics such as age, pelvic organ prolapse questionnaire (POP-Q), and number of previous gynecological operations in the women who did and did not return the questionnaires. Women’s baseline characteristics, clinical measurements, and dynamic MR imaging measurements are shown in Table 1. All women had at least one vaginal delivery. Ninety percent of the women had a history of one or more gynecological operations, i.e., hysterectomy, POP surgery, or urinary incontinence surgery. There were some negative values of the calculated value of perineal mobility, which were within the range of reproducibility, except for two values which were the result of levator coactivation during straining, and thus perineal elevation.

Table 1

Characteristics of the women included in this study

	n	Median (range)/n (%)
Baseline characteristics
Age (years)	69	54 (31-75)
BMI (kg/m2)	47	26 (20-36)
Parity	65	2 (1-6)
Number of previous gynecological operations	69
None		7 (10%)
1 or 2 operations		22 (32%)
≥3 operations		40 (58%)
Types of gynecological surgerya	69
POP surgery		34 (49%)
Urinary incontinence surgery		16 (23%)
Hysterectomy		39 (57%)
Clinical measurements
POP-Q (cm)b	66
Ba		−2 (−3 to +4)
C		−6 (−9 to +3)
Bp		0 (−3 to +4)
UDI
Urinary incontinence	63	17 (0-100)
Domain score < 33.33		35 (56%)
Domain score ≥ 33.33		28 (44%)
Genital prolapse	65	33 (0-100)
Domain score < 33.33		28 (43%)
Domain score ≥ 33.33		37 (57%)
DDI
Constipation	65	17 (0-100)
Domain score < 33.33		42 (65%)
Domain score ≥ 33.33		23 (35%)
Obstructed defecation	65	17 (0-83)
Domain score < 33.33		46 (71%)
Domain score ≥ 33.33		19 (29%)
Pain	65	0 (0-100)
Domain score < 33.33		43 (66%)
Domain score ≥ 33.33		22 (34%)
Fecal incontinence	66	17 (0-100)
Domain score < 33.33		42 (64%)
Domain score ≥ 33.33		24 (36%)
Flatulence	66	33 (0-100)
Domain score < 33.33		41 (62%)
Domain score ≥ 33.33		25 (38%)
MR imaging measurements (cm)c
Perineal position at rest	69	5.3 (2.8-8.5)
Perineal position during strain		7.1 (3.5-10.7)
Perineal mobilityd		1.7 (−1.1 to 4.8)

n number of patients, BMI body mass index, POP(-Q) Pelvic Organ Prolapse (Quantification), Ba most descended edge on the anterior vaginal wall during strain, C most descended edge of the cervix or vaginal vault during strain, Bp most descended edge on the posterior vagina wall during strain, cm centimeters, UDI Urogenital Distress Inventory, DDI Defecatory Distress Inventory

Patients may have had multiple previous gynecological surgeries

bRelative to the hymen

cRelative to the pubococcygeal line

dMeasurement of the perineal position during strain minus the measurement of the perineal position at rest

Table 2 shows the crude odds ratio with 95% confidence interval, for the probability of symptoms (questionnaire domain scores), of the baseline characteristics (age, BMI, and parity). Only age was statistically significant related to complaints of fecal incontinence (OR = 1.07, 95% CI = 1.01-1.13).

Table 2

The crude odds ratio with 95% confidence interval, for the probability of symptoms, of the baseline characteristics, with use of univariate logistic regression analyses

Symptoms	Age (years)		BMI (kg/m2)		Parity (number)
	n	OR (95% CI)	n	OR (95% CI)	n	OR (95% CI)
UDI
Urinary incontinence	63	1.01 (0.96-1.06)	44	1.09 (0.90-1.31)	60	1.20 (0.67-2.17)
Genital prolapse	65	1.02 (0.97-1.07)	45	0.95 (0.80-1.13)	62	1.31 (0.71-2.42)
DDI
Constipation	65	1.01 (0.95-1.06)	46	1.04 (0.87-1.25)	62	1.68 (0.88-3.20)
Obstructed defecation	65	1.00 (0.95-1.05)	45	0.99 (0.83-1.19)	62	1.35 (0.74-2.44)
Pain	65	0.98 (0.93-1.04)	45	0.98 (0.81-1.19)	62	1.55 (0.83-2.89)
Fecal incontinence	66	1.07 (1.01-1.13)	45	0.92 (0.75-1.13)	63	1.17 (0.65-2.12)
Flatulence	66	1.02 (0.97-1.08)	45	1.15 (0.93-1.42)	63	1.19 (0.58-2.44)

BMI body mass index, n number of patients, OR odds ratio, CI confidence interval, UDI Urogenital Distress Inventory, DDI Defecatory Distress Inventory

The Spearman’s correlation coefficient between the baseline characteristics (age, BMI, and parity) and the perineal position and mobility was assessed. Aging was statistically significant, but only poorly correlated with the position of the perineum during strain (r s = −0.29, p = 0.01).

The correlation between the perineal position at rest and the perineal position during strain was statistically significant (r s = 0.53, p = 0.00). The correlations among the baseline characteristics (age, BMI, and parity) were not statistically significant.

Table 3 presents the crude odds ratio with 95% confidence interval for the probability of symptoms (questionnaire domain scores), of the perineal position, perineal mobility, and a history of previous gynecological surgery. Women with a lowered position of the perineum at rest have an increased risk of prolapse symptoms (OR = 2.15, 95% CI = 1.18-3.91). None of the other UDI or DDI domain scores was associated with the MR imaging measurements. Women with a history of prior gynecological surgery had statistically significant more prolapse symptoms (OR = 9.81, 95% CI = 1.11-87.01).

Table 3

The crude odds ratio with 95% confidence interval, for the probability of symptoms, of the perineal position and mobility (as measured on dynamic MR imaging), and previous gynecological operation with use of univariate logistic regression analyses

Symptoms	n	Perineal position at rest (cm) OR (95% CI)	Perineal position during strain (cm) OR (95% CI)	Perineal mobilitya (cm) OR (95% CI)	Previous operation OR (95% CI)
UDI
Urinary incontinence	63	1.16 (0.71-1.88)	0.81 (0.55-1.19)	0.66 (0.41-1.05)	1.68 (0.28-9.90)
Genital prolapse	65	2.15 (1.18-3.91)	1.37 (0.93-2.06)	0.88 (0.57-1.36)	9.81 (1.11-87.01)
DDI
Constipation	65	1.22 (0.70-2.11)	1.23 (0.78-1.92)	0.80 (0.51-1.27)	0.81 (0.14-4.84)
Obstructed defecation	65	1.51 (0.87-2.61)	1.07 (0.71-1.62)	1.09 (0.68-1.75)	1.11 (0.19-6.55)
Pain	65	0.95 (0.57-1.57)	0.92 (0.62-1.37)	0.93 (0.59-1.47)	1.32 (0.23-7.40)
Fecal incontinence	66	0.72 (0.43-1.20)	0.76 (0.51-1.14)	0.92 (0.59-1.43)	0.49 (0.27-8.32)
Flatulence	66	1.02 (0.59-1.77)	0.82 (0.53-1.28)	0.76 (0.47-1.25)	0.45 (0.05-4.02)

cm centimeters relative to the pubococcygeal line, n number of patients, OR odds ratio, CI confidence interval, UDI Urogenital Distress Inventory, DDI Defecatory Distress Inventory

aMeasurement of the perineal position during strain minus the measurement of the perineal position at rest

Using multivariate logistic regression, none of the baseline characteristics (age, BMI, and parity) showed to be a confounder in the relations afore mentioned.

Discussion

This observational dynamic MR imaging study reports on the relation between the position and mobility of the perineum and patients’ symptoms of pelvic floor dysfunction (i.e., anorectal dysfunction, prolapse, and urinary incontinence) using standardized questionnaires. Only pelvic organ prolapse symptoms at rest were associated with the degree of descent of the perineum. No association was found between perineal descent and symptoms of anorectal and/or urinary incontinence.

The present results are in agreement with earlier studies on symptoms of constipation, rectal or pelvic pain, and urinary incontinence since the vast majority of studies produced evidence for the absence of a statistically significant correlation with perineal descent [8–11, 16, 17]. Previous studies on the relation between perineal descent and fecal incontinence and obstructed defecation were conflicting [9, 10, 12–15]. In our study, we did not find a relation with regards to these symptoms.

The available studies, in which prolapse symptoms in relation to perineal descent had been assessed, have also reported a statistically significant correlation [11, 17]. In one of these studies, perineal descent had also been assessed with dynamic MR imaging [17]. In accordance with the present study, the pubococcygeal line and the sphincter ani muscle had been used as reference line and measurement point. In contrast, however, Hoyte et al. have reported no significant difference between the measurement of the perineum at rest in patients with and without symptoms of prolapse, but have found a statistically significant difference during straining. We did not find a good explanation for the fact that in the present study, a relation at rest was found, but not at strain, even though the rest and strain measurements were correlated.

The estimated OR for the relation of the perineal position and mobility with pain are all much closer to 1.00 (0.93-0.95) compared to nearly all other symptoms. Therefore, it is unlikely that, in this study, of all symptoms the relation of pain with the perineal position and mobility is of clinically relevance. Although the number of participants in this study is limited, Table 3 shows that this study is large enough to detect an OR of 2.15/cm increase in perineal position and mobility.

To our knowledge, no previous studies have assessed the patients’ BMI in relation to perineal descent. Although a high BMI seems a theoretical risk factor for perineal descent, no association could be established. The same held true for age and parity, although others have previously described a relation with perineal descent for these parameters [3, 4, 7, 24, 25].

We have assessed the agreement between the perineal position during straining and POP-Q points Ba, C, and Bp [26]. No statistically significant correlation has been found (data not shown). The study was performed in a tertiary referral center. One of the reasons for referral to our center is when there is a discrepancy between symptoms and clinical findings. This implies that patients where POP-Q findings could not explain symptoms were overrepresented. Therefore, this population is very appropriate to assess a relation between symptoms of pelvic floor dysfunction and less obvious measurements such as perineal descent. Even in this population where rare conditions are expected to be overrepresented, perineal descent only showed a limited correlation with symptoms. In our opinion, this shows that the clinical value of this measurement is probably limited.

The observational character of this study is a limitation. Only 60% of the women who have had dynamic MR imaging investigation of the pelvic floor had returned or completed the questionnaires. Furthermore, MR imaging was performed as part of routine clinical practice in patients with recurrent prolapse, especially in the posterior compartment and consequently these women had only little anterior or apical prolapse.

A shared problem, in the literature and this manuscript, is the lack of a method to objectively assess the effort of strain during MR examination of the pelvic floor. Other methods which have been used in the literature for standardization are the respiratory peak flow meter [27], the reversal of flow in the femoral veins as seen on the axial MR images [28], and repetitive cycles of straining until the degree of protrusion remained constant [29]. Whether one method is preferable is unknown.

We have assessed perineal descent in one direction and in one plane only. It is, however, unknown whether the direction of the movement of the perineum during strain varies and whether perineal bulging was adequately assessed by our measurements. We have not assessed for parallel displacement in relation to the pubococcygeal line, but only the perpendicular one. This might be relevant and thus a limitation of our study. The presence of a levator ani hernia, unilateral, or bilateral, has been described in association with perineal descent [30]. Although the significance of levator ani hernia is unknown, the presence of these hernias has not been assessed in this study. Dynamic MR imaging assessment in the coronal or axial plane may be a valuable adjunct in the evaluation of patients who present with the physical findings of perineal descent. No significant differences in symptoms of anorectal dysfunction, urinary incontinence, and pelvic pain in patients with or without a levator ani hernia, however, have been described thus far [30].

It is furthermore imaginable that the patients’ symptoms associated with perineal descent are still undefined, and that the right questions were just not asked. Considerable perineal descent might for example be accompanied by a heavy feeling in the lower abdomen and the pelvic floor. These questions were not represented in the questionnaires and further research is needed in this respect.

In conclusion, only pelvic organ prolapse symptoms were associated with the degree of descent of the perineum, but not the anorectal symptoms and symptoms of urinary incontinence. The clinical impact of perineal descent in urogynecology is still unclear at this time point. In view of our results it seems, however, justified to promote further research with regards to the descending perineum syndrome.

Table 4

Defecation distress inventory

Symptom	Question
Constipation	a. Do you have fewer than three episodes of bowel movement a week?
	1. Yes		2. No (please proceed to the next question)
	b. If yes, how much does this bother you?
	1. Not at all	2. Somewhat	3. Quite a bit	4. A lot
	a. Do you have to strain more than 25% of the time to produce any stool?
	1. Yes		2. No (please proceed to the next question)
	b. If yes, how much does this bother you?
	1. Not at all	2. Somewhat	3. Quite a bit	4. A lot
Obstructed defecation	a. Do you ever experience the urge to defecate without producing any stool once on the toilet?
	1. Yes		2. No (please proceed to the next question)
	b. If yes, how much does this bother you?
	1. Not at all	2. Somewhat	3. Quite a bit	4. A lot
	a. Do you ever experience a sensation of something extending out of the anus or anal blockage?
	1. Yes		2. No (please proceed to the next question)
	b. If yes, how much does this bother you?
	1. Not at all	2. Somewhat	3. Quite a bit	4. A lot
	a. Do you ever need to push at the vaginal wall to induce bowel movement?
	1. Yes		2. No (please proceed to the next question)
	b. If yes, how much does this bother you?
	1. Not at all	2. Somewhat	3. Quite a bit	4. A lot
	a. Do you ever need to remove stool from the anus by using your fingers?
	1. Yes		2. No (please proceed to the next question)
	b. If yes, how much does this bother you?
	1. Not at all	2. Somewhat	3. Quite a bit	4. A lot
Pain	a. Do you experience pain during periods of urge for defecation?
	1. Yes		2. No (please proceed to the next question)
	b. If yes, how much does this bother you?
	1. Not at all	2. Somewhat	3. Quite a bit	4. A lot
	a. Do you experience pain during or shortly after bowel movement?
	1.Yes		2. No (please proceed to the next question)
	b. If yes, how much does this bother you?
	1. Not at all	2. Somewhat	3. Quite a bit	4. A lot
Fecal incontinence	a. Do you experience incontinence for liquid stool?
	1. Yes		2. No (please proceed to the next question)
	b. If yes, how much does this bother you?
	1. Not at all	2. Somewhat	3. Quite a bit	4. A lot
	c. How often does this occur?
	1. Daily
	2. Several times a week
	3. Once a week
	4. Once a month
	5. once a year
	a. Do you experience incontinence for solid stool?
	1. Yes		2. No (please proceed to the next question)
	b. If yes, how much does this bother you?
	1. Not at all	2. Somewhat	3. Quite a bit	4. A lot
	c. How often does this occur?
	1. Daily
	2. Several times a week
	3. Once a week
	4. Once a month
	5. Once a year
Flatulence	a. Do you experience flatulence beyond your control?
	1. Yes		2. No (please proceed to the next question)
	b. If yes, how much does this bother you?
	1. Not at all	2. Somewhat	3. Quite a bit	4. A lot
	c. How often does this occur?
	1. Daily
	2. Several times a week
	3. Once a week
	4. Once a month
	5. Once a year