OBJECTIVE: An increased risk of ALS has been reported for US veterans, but the cause is unknown. Since head injury and cigarette smoking are two previously implicated environmental risk factors that are more common in military than civilian study populations, we tested their association with ALS in a US veteran study population. METHODS: We used logistic regression to examine the association of ALS with head injury and cigarette smoking in 241 incident cases and 597 controls. Since APOE is a plausible ALS candidate gene, we also tested its main effect and its statistical interaction with these environmental exposures. RESULTS: Cigarette smoking was not associated with ALS in this predominantly male and Caucasian population. Veterans who had experienced head injuries during the last 15years before the reference date had an adjusted odds ratio of 2.33 (95% confidence interval 1.18-4.61), relative to veterans without any head injuries. This association was strongest in APOE-4 carriers. CONCLUSIONS: Our results add to the body of evidence suggesting that head injuries may be a risk factor for multiple neurodegenerative diseases, including ALS. We hypothesize that the strength of association between head injuries and ALS may depend upon APOE genotype. Copyright 2010 Elsevier B.V. All rights reserved.
OBJECTIVE: An increased risk of ALS has been reported for US veterans, but the cause is unknown. Since head injury and cigarette smoking are two previously implicated environmental risk factors that are more common in military than civilian study populations, we tested their association with ALS in a US veteran study population. METHODS: We used logistic regression to examine the association of ALS with head injury and cigarette smoking in 241 incident cases and 597 controls. Since APOE is a plausible ALS candidate gene, we also tested its main effect and its statistical interaction with these environmental exposures. RESULTS: Cigarette smoking was not associated with ALS in this predominantly male and Caucasian population. Veterans who had experienced head injuries during the last 15years before the reference date had an adjusted odds ratio of 2.33 (95% confidence interval 1.18-4.61), relative to veterans without any head injuries. This association was strongest in APOE-4 carriers. CONCLUSIONS: Our results add to the body of evidence suggesting that head injuries may be a risk factor for multiple neurodegenerative diseases, including ALS. We hypothesize that the strength of association between head injuries and ALS may depend upon APOE genotype. Copyright 2010 Elsevier B.V. All rights reserved.
Authors: Margaret A K Ryan; Tyler C Smith; Besa Smith; Paul Amoroso; Edward J Boyko; Gregory C Gray; Gary D Gackstetter; James R Riddle; Timothy S Wells; Gia Gumbs; Thomas E Corbeil; Tomoko I Hooper Journal: J Clin Epidemiol Date: 2006-09-28 Impact factor: 6.437
Authors: B L Plassman; R J Havlik; D C Steffens; M J Helms; T N Newman; D Drosdick; C Phillips; B A Gau; K A Welsh-Bohmer; J R Burke; J M Guralnik; J C Breitner Journal: Neurology Date: 2000-10-24 Impact factor: 9.910
Authors: Samuel M Goldman; Caroline M Tanner; David Oakes; Grace S Bhudhikanok; Anjali Gupta; J William Langston Journal: Ann Neurol Date: 2006-07 Impact factor: 10.422
Authors: L A Farrer; L A Cupples; J L Haines; B Hyman; W A Kukull; R Mayeux; R H Myers; M A Pericak-Vance; N Risch; C M van Duijn Journal: JAMA Date: 1997 Oct 22-29 Impact factor: 56.272
Authors: Freya Kamel; David M Umbach; Lillian Stallone; Marie Richards; Howard Hu; Dale P Sandler Journal: Environ Health Perspect Date: 2008-07 Impact factor: 9.031
Authors: Ann C McKee; Brandon E Gavett; Robert A Stern; Christopher J Nowinski; Robert C Cantu; Neil W Kowall; Daniel P Perl; E Tessa Hedley-Whyte; Bruce Price; Chris Sullivan; Peter Morin; Hyo-Soon Lee; Caroline A Kubilus; Daniel H Daneshvar; Megan Wulff; Andrew E Budson Journal: J Neuropathol Exp Neurol Date: 2010-09 Impact factor: 3.685
Authors: David C Perry; Virginia E Sturm; Matthew J Peterson; Carl F Pieper; Thomas Bullock; Bradley F Boeve; Bruce L Miller; Kevin M Guskiewicz; Mitchel S Berger; Joel H Kramer; Kathleen A Welsh-Bohmer Journal: J Neurosurg Date: 2015-08-28 Impact factor: 5.115
Authors: Christina N Fournier; Marla Gearing; Saila R Upadhyayula; Mitch Klein; Jonathan D Glass Journal: Neurology Date: 2015-04-01 Impact factor: 9.910
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Authors: Teresa M Evans; Holly Van Remmen; Anjali Purkar; Swetha Mahesula; J Al Gelfond; Marian Sabia; Wenbo Qi; Ai-Ling Lin; Carlos A Jaramillo; William E Haskins Journal: Transl Proteom Date: 2014-06-01
Authors: John D Beard; Lawrence S Engel; David B Richardson; Marilie D Gammon; Coleen Baird; David M Umbach; Kelli D Allen; Catherine L Stanwyck; Jean Keller; Dale P Sandler; Silke Schmidt; Freya Kamel Journal: Environ Int Date: 2016-02-23 Impact factor: 9.621
Authors: Erika N Guerrero; Haibo Wang; Joy Mitra; Pavana M Hegde; Sara E Stowell; Nicole F Liachko; Brian C Kraemer; Ralph M Garruto; K S Rao; Muralidhar L Hegde Journal: Prog Neurobiol Date: 2016-09-28 Impact factor: 11.685
Authors: Brandon E Gavett; Robert A Stern; Robert C Cantu; Christopher J Nowinski; Ann C McKee Journal: Alzheimers Res Ther Date: 2010-06-25 Impact factor: 6.982