OBJECTIVE: To determine, using a systematic review of case-control studies, whether head injury is a significant risk factor for Alzheimer's disease. We sought to replicate the findings of the meta-analysis of Mortimer et al (1991). METHODS: A predefined inclusion criterion specified case-control studies eligible for inclusion. A comprehensive and systematic search of various electronic databases, up to August 2001, was undertaken. Two independent reviewers screened studies for eligibility. Fifteen case-control studies were identified that met the inclusion criteria, of which seven postdated the study of Mortimer et al. RESULTS: We partially replicated the results of Mortimer et al. The meta-analysis of the seven studies conducted since 1991 did not reach significance. However, analysis of all 15 case-control studies was significant (OR 1.58, 95% CI 1.21 to 2.06), indicating an excess history of head injury in those with Alzheimer's disease. The finding of Mortimer et al that head injury is a risk factor for Alzheimer's disease only in males was replicated. The excess risk of head injury in those with Alzheimer's disease is only found in males (males: OR 2.29, 95% CI 1.47 to 2.06; females: OR 0.91, 95% CI 0.56 to 1.47). CONCLUSIONS: This study provides support for an association between a history of previous head injury and the risk of developing Alzheimer's disease.
OBJECTIVE: To determine, using a systematic review of case-control studies, whether head injury is a significant risk factor for Alzheimer's disease. We sought to replicate the findings of the meta-analysis of Mortimer et al (1991). METHODS: A predefined inclusion criterion specified case-control studies eligible for inclusion. A comprehensive and systematic search of various electronic databases, up to August 2001, was undertaken. Two independent reviewers screened studies for eligibility. Fifteen case-control studies were identified that met the inclusion criteria, of which seven postdated the study of Mortimer et al. RESULTS: We partially replicated the results of Mortimer et al. The meta-analysis of the seven studies conducted since 1991 did not reach significance. However, analysis of all 15 case-control studies was significant (OR 1.58, 95% CI 1.21 to 2.06), indicating an excess history of head injury in those with Alzheimer's disease. The finding of Mortimer et al that head injury is a risk factor for Alzheimer's disease only in males was replicated. The excess risk of head injury in those with Alzheimer's disease is only found in males (males: OR 2.29, 95% CI 1.47 to 2.06; females: OR 0.91, 95% CI 0.56 to 1.47). CONCLUSIONS: This study provides support for an association between a history of previous head injury and the risk of developing Alzheimer's disease.
Authors: A Hofman; W Schulte; T A Tanja; C M van Duijn; R Haaxma; A J Lameris; V M Otten; R J Saan Journal: Neurology Date: 1989-12 Impact factor: 9.910
Authors: G A Broe; A S Henderson; H Creasey; E McCusker; A E Korten; A F Jorm; W Longley; J C Anthony Journal: Neurology Date: 1990-11 Impact factor: 9.910
Authors: L A Amaducci; L Fratiglioni; W A Rocca; C Fieschi; P Livrea; D Pedone; L Bracco; A Lippi; C Gandolfo; G Bino Journal: Neurology Date: 1986-07 Impact factor: 9.910
Authors: Ann C McKee; Brandon E Gavett; Robert A Stern; Christopher J Nowinski; Robert C Cantu; Neil W Kowall; Daniel P Perl; E Tessa Hedley-Whyte; Bruce Price; Chris Sullivan; Peter Morin; Hyo-Soon Lee; Caroline A Kubilus; Daniel H Daneshvar; Megan Wulff; Andrew E Budson Journal: J Neuropathol Exp Neurol Date: 2010-09 Impact factor: 3.685
Authors: David C Perry; Virginia E Sturm; Matthew J Peterson; Carl F Pieper; Thomas Bullock; Bradley F Boeve; Bruce L Miller; Kevin M Guskiewicz; Mitchel S Berger; Joel H Kramer; Kathleen A Welsh-Bohmer Journal: J Neurosurg Date: 2015-08-28 Impact factor: 5.115
Authors: Christian LoBue; Kristin Wilmoth; C Munro Cullum; Heidi C Rossetti; Laura H Lacritz; Linda S Hynan; John Hart; Kyle B Womack Journal: J Neurol Neurosurg Psychiatry Date: 2015-09-10 Impact factor: 10.154
Authors: Ji Zhang; Suqing Wang; Wei Huang; David A Bennett; Dennis W Dickson; Dengshun Wang; Rui Wang Journal: Mol Neurobiol Date: 2015-09-19 Impact factor: 5.590
Authors: Raquel C Gardner; Ernesto Rivera; Megan O'Grady; Colin Doherty; Kristine Yaffe; John D Corrigan; Jennifer Bogner; Joel Kramer; Fiona Wilson Journal: J Alzheimers Dis Date: 2020 Impact factor: 4.472