INTRODUCTION: Carotid intima-media thickness (IMT) is a subclinical marker of atherosclerosis and a strong predictor of stroke. Pericardial fat (PF), the fat depot around the heart, has been associated with several atherosclerosis risk factors. We sought to examine the association between carotid IMT and PF, and to examine whether such an association is independent from common atherosclerosis risk factors including measures of overall adiposity. METHODS: Unadjusted and multivariable-adjusted linear regression analysis was used to examine associations between common carotid artery (CCA) IMT and internal carotid artery (ICA) IMT with PF in a random sample of 996 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent carotid ultrasound and chest computed tomography at baseline examination. RESULTS: A significant positive correlation was observed between PF and CCA-IMT (r=0.27, P < .0001) and ICA-IMT (r=0.17, P < .0001). In an unadjusted sex-specific linear regression analysis, there was a significant association between PF (1-SD difference) and CCA-IMT (mm) in both women (beta coefficient [95% confidence interval]: 0.06 [0.04, 0.08], P < .0001) and men (0.03 [0.01, 0.05], P < .0002), an association that persisted after further adjusting for age and ethnicity (0.02 [+0.00, 0.04], P=.0120 for women, and 0.02 [+0.00, 0.03], P=.0208 for men). However, after additional adjustment for atherosclerosis risk factors and either body mass index or waist circumference, these relations were no longer significant in either sex. In similar analyses, PF was significantly associated with ICA-IMT in both men (0.11 [0.06, 0.15], P < .0001) and women (0.08 [0.02, 0.13], P=.0041). These relations were no longer significant in women in multivariable-adjusted models, but persisted in men in all models except after adjusting for age, ethnicity, and waist circumference. CONCLUSIONS: In the general population PF is associated with carotid IMT, an association that possibly is not independent from markers of overall adiposity or common atherosclerosis risk factors. (c) 2010 National Stroke Association. Published by Elsevier Inc. All rights reserved.
INTRODUCTION: Carotid intima-media thickness (IMT) is a subclinical marker of atherosclerosis and a strong predictor of stroke. Pericardial fat (PF), the fat depot around the heart, has been associated with several atherosclerosis risk factors. We sought to examine the association between carotid IMT and PF, and to examine whether such an association is independent from common atherosclerosis risk factors including measures of overall adiposity. METHODS: Unadjusted and multivariable-adjusted linear regression analysis was used to examine associations between common carotid artery (CCA) IMT and internal carotid artery (ICA) IMT with PF in a random sample of 996 participants from the Multi-Ethnic Study of Atherosclerosis (MESA) who underwent carotid ultrasound and chest computed tomography at baseline examination. RESULTS: A significant positive correlation was observed between PF and CCA-IMT (r=0.27, P < .0001) and ICA-IMT (r=0.17, P < .0001). In an unadjusted sex-specific linear regression analysis, there was a significant association between PF (1-SD difference) and CCA-IMT (mm) in both women (beta coefficient [95% confidence interval]: 0.06 [0.04, 0.08], P < .0001) and men (0.03 [0.01, 0.05], P < .0002), an association that persisted after further adjusting for age and ethnicity (0.02 [+0.00, 0.04], P=.0120 for women, and 0.02 [+0.00, 0.03], P=.0208 for men). However, after additional adjustment for atherosclerosis risk factors and either body mass index or waist circumference, these relations were no longer significant in either sex. In similar analyses, PF was significantly associated with ICA-IMT in both men (0.11 [0.06, 0.15], P < .0001) and women (0.08 [0.02, 0.13], P=.0041). These relations were no longer significant in women in multivariable-adjusted models, but persisted in men in all models except after adjusting for age, ethnicity, and waist circumference. CONCLUSIONS: In the general population PF is associated with carotid IMT, an association that possibly is not independent from markers of overall adiposity or common atherosclerosis risk factors. (c) 2010 National Stroke Association. Published by Elsevier Inc. All rights reserved.
Authors: Guy L Wheeler; Rong Shi; Stephanie R Beck; Carl D Langefeld; Leon Lenchik; Lynne E Wagenknecht; Barry I Freedman; Stephen S Rich; Donald W Bowden; Michael Y Chen; J Jeffrey Carr Journal: Invest Radiol Date: 2005-02 Impact factor: 6.016
Authors: Diane E Bild; Robert Detrano; Do Peterson; Alan Guerci; Kiang Liu; Eyal Shahar; Pamela Ouyang; Sharon Jackson; Mohammed F Saad Journal: Circulation Date: 2005-03-15 Impact factor: 29.690
Authors: Mikko Kankaanpää; Hanna-Riikka Lehto; Jussi P Pärkkä; Markku Komu; Antti Viljanen; Ele Ferrannini; Juhani Knuuti; Pirjo Nuutila; Riitta Parkkola; Patricia Iozzo Journal: J Clin Endocrinol Metab Date: 2006-08-22 Impact factor: 5.958
Authors: Gianluca Iacobellis; Adriano M Pellicelli; Arya M Sharma; Benvenuto Grisorio; Giorgio Barbarini; Giuseppe Barbaro Journal: Am J Cardiol Date: 2007-04-05 Impact factor: 2.778
Authors: Jingzhong Ding; Stephen B Kritchevsky; Tamara B Harris; Gregory L Burke; Robert C Detrano; Moyses Szklo; J Jeffrey Carr Journal: Obesity (Silver Spring) Date: 2008-05-29 Impact factor: 5.002
Authors: Guido A Rosito; Joseph M Massaro; Udo Hoffmann; Frederick L Ruberg; Amir A Mahabadi; Ramachandran S Vasan; Christopher J O'Donnell; Caroline S Fox Journal: Circulation Date: 2008-01-22 Impact factor: 29.690
Authors: Patrizio Prati; Alberto Tosetto; Diego Vanuzzo; Giovanni Bader; Marco Casaroli; Luigi Canciani; Sergio Castellani; Pierre-Jean Touboul Journal: Stroke Date: 2008-07-10 Impact factor: 7.914
Authors: Jingzhong Ding; Stephen B Kritchevsky; Fang-Chi Hsu; Tamara B Harris; Gregory L Burke; Robert C Detrano; Moyses Szklo; Michael H Criqui; Matthew Allison; Pamela Ouyang; Elizabeth R Brown; J Jeffrey Carr Journal: Am J Clin Nutr Date: 2008-09 Impact factor: 7.045
Authors: Diane E Bild; David A Bluemke; Gregory L Burke; Robert Detrano; Ana V Diez Roux; Aaron R Folsom; Philip Greenland; David R Jacob; Richard Kronmal; Kiang Liu; Jennifer Clark Nelson; Daniel O'Leary; Mohammed F Saad; Steven Shea; Moyses Szklo; Russell P Tracy Journal: Am J Epidemiol Date: 2002-11-01 Impact factor: 4.897
Authors: N Hasegawa; S Fujie; T Kurihara; T Homma; K Sanada; K Sato; T Hamaoka; M Iemitsu Journal: J Hum Hypertens Date: 2016-05-12 Impact factor: 3.012
Authors: Gary Huang; Dan Wang; Irfan Zeb; Matthew J Budoff; S Mitchell Harman; Virginia Miller; Eliot A Brinton; Samar R El Khoudary; JoAnn E Manson; MaryFran R Sowers; Howard N Hodis; George R Merriam; Marcelle I Cedars; Hugh S Taylor; Frederick Naftolin; Rogerio A Lobo; Nanette Santoro; Rachel P Wildman Journal: Atherosclerosis Date: 2011-12-09 Impact factor: 5.162
Authors: Corey M Gill; Debora C Azevedo; Adriana L Oliveira; Edgar L Martinez-Salazar; Martin Torriani; Miriam A Bredella Journal: Acta Radiol Date: 2018-02-14 Impact factor: 1.990
Authors: Kwok-Leung Ong; Jingzhong Ding; Robyn L McClelland; Bernard M Y Cheung; Michael H Criqui; Philip J Barter; Kerry-Anne Rye; Matthew A Allison Journal: Atherosclerosis Date: 2015-06-18 Impact factor: 5.162
Authors: Aprilianto Eddy Wiria; Linda J Wammes; Firdaus Hamid; Olaf M Dekkers; Margaretta A Prasetyani; Linda May; Maria M M Kaisar; Jaco J Verweij; Jouke T Tamsma; Felix Partono; Erliyani Sartono; Taniawati Supali; Maria Yazdanbakhsh; Johannes W A Smit Journal: PLoS One Date: 2013-01-24 Impact factor: 3.240