BACKGROUND AND PURPOSE: Outcomes for selected patients with spinal metastases may be improved by dose escalation using stereotactic body radiation therapy (SBRT). As target geometry is complex, we compared SBRT plans using volumetric modulated arc radiotherapy (RapidArc, RA) and conventional intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS: RA and IMRT plans to deliver a fraction of 16 Gy to at least 90% of planning target volume (PTV) were compared for PTV coverage, normal organ sparing and estimated delivery times. Group 1 consisted of PTVs to only vertebral body (n=3), while group 2 had PTVs encompassing the entire vertebra (n=4). Finally, RA delivery parameters in four patients were assessed. RESULTS: Both techniques delivered 16 Gy to a mean of 95% and 85% of the PTV in groups 1 and 2, respectively. Spinal cord sparing was comparable; mean V(10-partial cord) for RA and IMRT in group 1 was 3.6%, and was 9.4% versus 11.5%, respectively, in group 2. Estimated mean treatment times for RA with 2-3 arcs and IMRT were comparable. Clinical RA beam-on times ranged from 11 to 15.4 min. CONCLUSIONS: Both RA and conventional IMRT plans deliver high quality vertebral SBRT, but plan quality was poorer when the PTV consisted of the entire vertebra. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
BACKGROUND AND PURPOSE: Outcomes for selected patients with spinal metastases may be improved by dose escalation using stereotactic body radiation therapy (SBRT). As target geometry is complex, we compared SBRT plans using volumetric modulated arc radiotherapy (RapidArc, RA) and conventional intensity-modulated radiotherapy (IMRT). MATERIALS AND METHODS:RA and IMRT plans to deliver a fraction of 16 Gy to at least 90% of planning target volume (PTV) were compared for PTV coverage, normal organ sparing and estimated delivery times. Group 1 consisted of PTVs to only vertebral body (n=3), while group 2 had PTVs encompassing the entire vertebra (n=4). Finally, RA delivery parameters in four patients were assessed. RESULTS: Both techniques delivered 16 Gy to a mean of 95% and 85% of the PTV in groups 1 and 2, respectively. Spinal cord sparing was comparable; mean V(10-partial cord) for RA and IMRT in group 1 was 3.6%, and was 9.4% versus 11.5%, respectively, in group 2. Estimated mean treatment times for RA with 2-3 arcs and IMRT were comparable. Clinical RA beam-on times ranged from 11 to 15.4 min. CONCLUSIONS: Both RA and conventional IMRT plans deliver high quality vertebral SBRT, but plan quality was poorer when the PTV consisted of the entire vertebra. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Authors: Matthew M Gestaut; Nitika Thawani; Sangroh Kim; Veera R Gutti; Sameer Jhavar; Niloyjyoti Deb; Andrew Morrow; Russell A Ward; Jason H Huang; Mehul Patel Journal: J Neurooncol Date: 2017-04-13 Impact factor: 4.130
Authors: David A Palma; Cornelis J A Haasbeek; George B Rodrigues; Max Dahele; Michael Lock; Brian Yaremko; Robert Olson; Mitchell Liu; Jason Panarotto; Gwendolyn H M J Griffioen; Stewart Gaede; Ben Slotman; Suresh Senan Journal: BMC Cancer Date: 2012-07-23 Impact factor: 4.430