BACKGROUND: The aim of that study was to analyze the impact of German-S3-breast cancer guideline adherence on clinical outcomes. METHODS: A retrospective study analyzed 3976 patients first diagnosed with primary breast cancer according to an S3-guideline-based model that classified patients retrospectively into groups receiving "guideline-adherent and "guideline non-adherent" therapy. RESULTS: There was a significant association between treatment adherence and prolonged recurrence free and overall survival (p = 0.0001). The greater the number of violations in guideline adherence, the lower was overall survival (p = 0.0001). Advanced age at initial diagnosis was additionally associated with a reduction in guideline adherence. The percentage of guideline adherence for the therapeutic modalities BCT, mastectomy, axillary dissection and hormone therapy was greater than 80%. For chemotherapy, the percent of guideline adherence totaled 71.4%. CONCLUSION: Therapies dispensed in adherence with guidelines may improve recurrence-free survival and overall survival in patients with breast cancer. Copyright 2009 Elsevier Ltd. All rights reserved.
BACKGROUND: The aim of that study was to analyze the impact of German-S3-breast cancer guideline adherence on clinical outcomes. METHODS: A retrospective study analyzed 3976 patients first diagnosed with primary breast cancer according to an S3-guideline-based model that classified patients retrospectively into groups receiving "guideline-adherent and "guideline non-adherent" therapy. RESULTS: There was a significant association between treatment adherence and prolonged recurrence free and overall survival (p = 0.0001). The greater the number of violations in guideline adherence, the lower was overall survival (p = 0.0001). Advanced age at initial diagnosis was additionally associated with a reduction in guideline adherence. The percentage of guideline adherence for the therapeutic modalities BCT, mastectomy, axillary dissection and hormone therapy was greater than 80%. For chemotherapy, the percent of guideline adherence totaled 71.4%. CONCLUSION: Therapies dispensed in adherence with guidelines may improve recurrence-free survival and overall survival in patients with breast cancer. Copyright 2009 Elsevier Ltd. All rights reserved.
Authors: Gabrielle B Rocque; Courtney P Williams; Bradford E Jackson; Audrey S Wallace; Karina I Halilova; Kelly M Kenzik; Edward E Partridge; Maria Pisu Journal: J Oncol Pract Date: 2016-11-15 Impact factor: 3.840
Authors: Courtney P Williams; Kelly M Kenzik; Andres Azuero; Grant R Williams; Maria Pisu; Karina I Halilova; Stacey A Ingram; Supriya K Yagnik; Andres Forero; Smita Bhatia; Gabrielle B Rocque Journal: Oncologist Date: 2018-08-17
Authors: A Wöckel; R Wolters; T Wiegel; I Novopashenny; W Janni; R Kreienberg; M Wischnewsky; L Schwentner Journal: Ann Oncol Date: 2014-02-09 Impact factor: 32.976