Literature DB >> 20107096

Rapid diagnosis of azole-resistant aspergillosis by direct PCR using tissue specimens.

Jan W M van der Linden1, Eveline Snelders, Jan P Arends, Simon M Daenen, Willem J G Melchers, Paul E Verweij.   

Abstract

We report the use of PCR techniques on a formalin-fixed and paraffin-embedded tissue specimen for direct detection of one dominant azole resistance mechanism in a case of disseminated invasive aspergillosis. Rapid detection of mutations associated with azole resistance directly in tissue significantly reduces diagnostic delay.

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Year:  2010        PMID: 20107096      PMCID: PMC2849623          DOI: 10.1128/JCM.02221-09

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN: 0095-1137            Impact factor:   5.948


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