Literature DB >> 19272019

Azole-resistant central nervous system aspergillosis.

Jan W M van der Linden1, Rogier R Jansen, Dorine Bresters, Caroline E Visser, Suzanne E Geerlings, Ed J Kuijper, Willem J G Melchers, Paul E Verweij.   

Abstract

Three patients with central nervous system aspergillosis due to azole-resistant Aspergillus fumigatus (associated with a leucine substitution for histidine at codon 98 [L98H] and a 34-base pair repeat in tandem in the promoter region) are described. The patients were treated with combination therapy or with polyenes, but all patients died. Azole resistance significantly complicates the management of aspergillosis by delaying the initiation of adequate therapy and because effective alternative antifungal drugs are lacking.

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Year:  2009        PMID： 19272019     DOI： 10.1086/597465

Source DB:  PubMed          Journal:  Clin Infect Dis        ISSN： 1058-4838            Impact factor:   9.079


  42 in total

1.  Molecular epidemiology of Aspergillus fumigatus isolates harboring the TR34/L98H azole resistance mechanism.

Authors:  Simone M T Camps; Antonius J M M Rijs; Corné H W Klaassen; Jacques F Meis; Céline M O'Gorman; Paul S Dyer; Willem J G Melchers; Paul E Verweij
Journal:  J Clin Microbiol       Date:  2012-06-06       Impact factor: 5.948

2.  Comparison of the broth microdilution methods of the European Committee on Antimicrobial Susceptibility Testing and the Clinical and Laboratory Standards Institute for testing itraconazole, posaconazole, and voriconazole against Aspergillus isolates.

Authors:  M Pfaller; L Boyken; R Hollis; J Kroeger; S Messer; S Tendolkar; D Diekema
Journal:  J Clin Microbiol       Date:  2011-01-05       Impact factor: 5.948

3.  Evaluating retinal toxicity of intravitreal caspofungin in the mouse eye.

Authors:  Deb K Mojumder; Francis A Concepcion; Shil K Patel; Andrew J Barkmeier; Petros E Carvounis; John H Wilson; Eric R Holz; Theodore G Wensel
Journal:  Invest Ophthalmol Vis Sci       Date:  2010-05-26       Impact factor: 4.799

Review 4.  [Resistant fungi].

Authors:  M J G T Vehreschild; O A Cornely
Journal:  Internist (Berl)       Date:  2015-11       Impact factor: 0.743

Review 5.  Rapid induction of multiple resistance mechanisms in Aspergillus fumigatus during azole therapy: a case study and review of the literature.

Authors:  Simone M T Camps; Jan W M van der Linden; Yi Li; Ed J Kuijper; Jaap T van Dissel; Paul E Verweij; Willem J G Melchers
Journal:  Antimicrob Agents Chemother       Date:  2011-10-17       Impact factor: 5.191

6.  In vitro acquisition of secondary azole resistance in Aspergillus fumigatus isolates after prolonged exposure to itraconazole: presence of heteroresistant populations.

Authors:  Pilar Escribano; Sandra Recio; Teresa Peláez; Milagros González-Rivera; Emilio Bouza; Jesús Guinea
Journal:  Antimicrob Agents Chemother       Date:  2011-10-17       Impact factor: 5.191

7.  Rapid diagnosis of azole-resistant aspergillosis by direct PCR using tissue specimens.

Authors:  Jan W M van der Linden; Eveline Snelders; Jan P Arends; Simon M Daenen; Willem J G Melchers; Paul E Verweij
Journal:  J Clin Microbiol       Date:  2010-01-27       Impact factor: 5.948

Review 8.  Molecular Tools for the Detection and Deduction of Azole Antifungal Drug Resistance Phenotypes in Aspergillus Species.

Authors:  Anna Dudakova; Birgit Spiess; Marut Tangwattanachuleeporn; Christoph Sasse; Dieter Buchheidt; Michael Weig; Uwe Groß; Oliver Bader
Journal:  Clin Microbiol Rev       Date:  2017-10       Impact factor: 26.132

9.  Development of azole resistance in Aspergillus fumigatus during azole therapy associated with change in virulence.

Authors:  Maiken Cavling Arendrup; Eleftheria Mavridou; Klaus Leth Mortensen; Eveline Snelders; Niels Frimodt-Møller; Humara Khan; Willem J G Melchers; Paul E Verweij
Journal:  PLoS One       Date:  2010-04-09       Impact factor: 3.240

10.  Frequency and evolution of Azole resistance in Aspergillus fumigatus associated with treatment failure.

Authors:  Susan J Howard; Dasa Cerar; Michael J Anderson; Ahmed Albarrag; Matthew C Fisher; Alessandro C Pasqualotto; Michel Laverdiere; Maiken C Arendrup; David S Perlin; David W Denning
Journal:  Emerg Infect Dis       Date:  2009-07       Impact factor: 6.883
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