Literature DB >> 20107067

Serine racemase deletion protects against cerebral ischemia and excitotoxicity.

Asif K Mustafa1, Abdullah S Ahmad, Emil Zeynalov, Sadia K Gazi, Gautam Sikka, Jeffrey T Ehmsen, Roxanne K Barrow, Joseph T Coyle, Solomon H Snyder, Sylvain Doré.   

Abstract

D-Serine, formed from L-serine by serine racemase (SR), is a physiologic coagonist at NMDA receptors. Using mice with targeted deletion of SR, we demonstrate a role for D-serine in NMDA receptor-mediated neurotoxicity and stroke. Brain cultures of SR-deleted mice display markedly diminished nitric oxide (NO) formation and neurotoxicity. In intact SR knock-out mice, NO formation and nitrosylation of NO targets are substantially reduced. Infarct volume following middle cerebral artery occlusion is dramatically diminished in several regions of the brains of SR mutant mice despite evidence of increased NMDA receptor number and sensitivity.

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Year:  2010        PMID： 20107067      PMCID： PMC2841469          DOI： 10.1523/JNEUROSCI.4297-09.2010

Source DB:  PubMed          Journal:  J Neurosci        ISSN： 0270-6474            Impact factor:   6.167


  18 in total

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Review 4.  D-serine regulation of NMDA receptor activity.

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Authors:  Paul M Kim; Hiroyuki Aizawa; Peter S Kim; Alex S Huang; Sasrutha R Wickramasinghe; Amir H Kashani; Roxanne K Barrow; Richard L Huganir; Anirvan Ghosh; Solomon H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-31       Impact factor: 11.205

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Authors:  Asif K Mustafa; Manish Kumar; Balakrishnan Selvakumar; Gary P H Ho; Jeffrey T Ehmsen; Roxanne K Barrow; L Mario Amzel; Solomon H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2007-02-09       Impact factor: 11.205

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Journal:  J Neurosci       Date:  2008-12-31       Impact factor: 6.167

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  34 in total

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2.  Enhanced astrocytic d-serine underlies synaptic damage after traumatic brain injury.

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6.  Paradoxical roles of serine racemase and D-serine in the G93A mSOD1 mouse model of amyotrophic lateral sclerosis.

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Review 7.  Controlling reaction specificity in pyridoxal phosphate enzymes.

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8.  Brain-specific Phgdh deletion reveals a pivotal role for L-serine biosynthesis in controlling the level of D-serine, an N-methyl-D-aspartate receptor co-agonist, in adult brain.

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9.  FBXO22 protein is required for optimal synthesis of the N-methyl-D-aspartate (NMDA) receptor coagonist D-serine.

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10.  Storage and uptake of D-serine into astrocytic synaptic-like vesicles specify gliotransmission.

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