Literature DB >> 15684087

Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration.

Paul M Kim1, Hiroyuki Aizawa, Peter S Kim, Alex S Huang, Sasrutha R Wickramasinghe, Amir H Kashani, Roxanne K Barrow, Richard L Huganir, Anirvan Ghosh, Solomon H Snyder.   

Abstract

Serine racemase (SR), localized to astrocytic glia that ensheathe synapses, converts L-serine to D-serine, an endogenous ligand of the NMDA receptor. We report the activation of SR by glutamate neurotransmission involving alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors via glutamate receptor interacting protein (GRIP) and the physiologic regulation of cerebellar granule cell migration by SR. GRIP physiologically binds SR, augmenting SR activity and D-serine release. GRIP infection of neonatal mouse cerebellum in vivo enhances granule cell migration. Selective degradation of D-serine by D-amino acid oxidase and pharmacologic inhibition of SR impede migration, whereas D-serine activates the process. Thus, in neuronal migration, glutamate stimulates Bergmann glia to form and release D-serine, which, together with glutamate, activates NMDA receptors on granule neurons, chemokinetically enhancing migration.

Entities:  

Mesh：

Substances：

Year:  2005        PMID： 15684087      PMCID： PMC548584          DOI： 10.1073/pnas.0409723102

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

1.  GRASP-1: a neuronal RasGEF associated with the AMPA receptor/GRIP complex.

Authors:  B Ye; D Liao; X Zhang; P Zhang; H Dong; R L Huganir
Journal:  Neuron       Date:  2000-06       Impact factor: 17.173

2.  Completion of neuronal migration regulated by loss of Ca(2+) transients.

Authors:  Tatsuro Kumada; Hitoshi Komuro
Journal:  Proc Natl Acad Sci U S A       Date:  2004-05-18       Impact factor: 11.205

3.  D-serine as a neuromodulator: regional and developmental localizations in rat brain glia resemble NMDA receptors.

Authors:  M J Schell; R O Brady; M E Molliver; S H Snyder
Journal:  J Neurosci       Date:  1997-03-01       Impact factor: 6.167

4.  Recognition of unique carboxyl-terminal motifs by distinct PDZ domains.

Authors:  Z Songyang; A S Fanning; C Fu; J Xu; S M Marfatia; A H Chishti; A Crompton; A C Chan; J M Anderson; L C Cantley
Journal:  Science       Date:  1997-01-03       Impact factor: 47.728

5.  Intracellular Ca2+ fluctuations modulate the rate of neuronal migration.

Authors:  H Komuro; P Rakic
Journal:  Neuron       Date:  1996-08       Impact factor: 17.173

6.  Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission.

Authors:  H Wolosker; S Blackshaw; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

7.  D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.

Authors:  J P Mothet; A T Parent; H Wolosker; R O Brady; D J Linden; C D Ferris; M A Rogawski; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

8.  The developmental onset of NMDA receptor-channel activity during neuronal migration.

Authors:  D J Rossi; N T Slater
Journal:  Neuropharmacology       Date:  1993-11       Impact factor: 5.250

9.  Endogenous D-serine in rat brain: N-methyl-D-aspartate receptor-related distribution and aging.

Authors:  A Hashimoto; T Nishikawa; T Oka; K Takahashi
Journal:  J Neurochem       Date:  1993-02       Impact factor: 5.372

10.  Determination of free amino acid enantiomers in rat brain and serum by high-performance liquid chromatography after derivatization with N-tert.-butyloxycarbonyl-L-cysteine and o-phthaldialdehyde.

Authors:  A Hashimoto; T Nishikawa; T Oka; K Takahashi; T Hayashi
Journal:  J Chromatogr       Date:  1992-11-06
View more
  73 in total

1.  A new look at glutamate and ischemia: NMDA agonist improves long-term functional outcome in a rat model of stroke.

Authors:  Jasbeer Dhawan; Helene Benveniste; Zhongchi Luo; Marta Nawrocky; S David Smith; Anat Biegon
Journal:  Future Neurol       Date:  2011-11-01

2.  Neuronal serine racemase associates with Disrupted-In-Schizophrenia-1 and DISC1 agglomerates: Implications for schizophrenia.

Authors:  Ariel A Jacobi; Sarah Halawani; David R Lynch; Hong Lin
Journal:  Neurosci Lett       Date:  2018-11-01       Impact factor: 3.046

3.  Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes.

Authors:  Masataka Suzuki; Jumpei Sasabe; Yurika Miyoshi; Kanako Kuwasako; Yutaka Muto; Kenji Hamase; Masaaki Matsuoka; Nobuaki Imanishi; Sadakazu Aiso
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-13       Impact factor: 11.205

4.  AMPA receptor-dependent, light-evoked D-serine release acts on retinal ganglion cell NMDA receptors.

Authors:  Steve J Sullivan; Robert F Miller
Journal:  J Neurophysiol       Date:  2012-05-16       Impact factor: 2.714

5.  Differential gene expression and functional analysis implicate novel mechanisms in enteric nervous system precursor migration and neuritogenesis.

Authors:  Bhupinder P S Vohra; Keiji Tsuji; Mayumi Nagashimada; Toshihiro Uesaka; Daniel Wind; Ming Fu; Jennifer Armon; Hideki Enomoto; Robert O Heuckeroth
Journal:  Dev Biol       Date:  2006-06-27       Impact factor: 3.582

6.  Glutamatergic and purinergic receptor-mediated calcium transients in Bergmann glial cells.

Authors:  Richard Piet; Craig E Jahr
Journal:  J Neurosci       Date:  2007-04-11       Impact factor: 6.167

7.  TRPA1 channels are regulators of astrocyte basal calcium levels and long-term potentiation via constitutive D-serine release.

Authors:  Eiji Shigetomi; Olan Jackson-Weaver; Robert T Huckstepp; Thomas J O'Dell; Baljit S Khakh
Journal:  J Neurosci       Date:  2013-06-12       Impact factor: 6.167

8.  D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis.

Authors:  Jumpei Sasabe; Tomohiro Chiba; Marina Yamada; Koichi Okamoto; Ikuo Nishimoto; Masaaki Matsuoka; Sadakazu Aiso
Journal:  EMBO J       Date:  2007-08-30       Impact factor: 11.598

9.  In vivo D-serine hetero-exchange through alanine-serine-cysteine (ASC) transporters detected by microelectrode biosensors.

Authors:  Caroline Maucler; Pierre Pernot; Natalia Vasylieva; Loredano Pollegioni; Stéphane Marinesco
Journal:  ACS Chem Neurosci       Date:  2013-04-12       Impact factor: 4.418

Review 10.  NMDA receptor regulation by D-serine: new findings and perspectives.

Authors:  Herman Wolosker
Journal:  Mol Neurobiol       Date:  2007-09-12       Impact factor: 5.590
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.