Literature DB >> 17293453

Nitric oxide S-nitrosylates serine racemase, mediating feedback inhibition of D-serine formation.

Asif K Mustafa1, Manish Kumar, Balakrishnan Selvakumar, Gary P H Ho, Jeffrey T Ehmsen, Roxanne K Barrow, L Mario Amzel, Solomon H Snyder.   

Abstract

Serine racemase (SR) generates D-serine, a coagonist with glutamate at NMDA receptors. We show that SR is physiologically S-nitrosylated leading to marked inhibition of enzyme activity. Inhibition involves interactions with the cofactor ATP reflecting juxtaposition of the ATP-binding site and cysteine-113 (C113), the site for physiological S-nitrosylation. NMDA receptor physiologically enhances SR S-nitrosylation by activating neuronal nitric-oxide synthase (nNOS). These findings support a model whereby postsynaptic stimulation of nitric-oxide (NO) formation feeds back to presynaptic cells to S-nitrosylate SR and decrease D-serine availability to postsynaptic NMDA receptors.

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Year:  2007        PMID： 17293453      PMCID： PMC1815287          DOI： 10.1073/pnas.0611620104

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  21 in total

1.  Glia-derived D-serine controls NMDA receptor activity and synaptic memory.

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Authors:  Kazuo Shoji; Sofia Mariotto; Anna Rosa Ciampa; Hisanori Suzuki
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3.  Regulation of serine racemase activity by D-serine and nitric oxide in human glioblastoma cells.

Authors:  Kazuo Shoji; Sofia Mariotto; Anna Rosa Ciampa; Hisanori Suzuki
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4.  Receptor-regulated dynamic S-nitrosylation of endothelial nitric-oxide synthase in vascular endothelial cells.

Authors:  Phillip A Erwin; Alison J Lin; David E Golan; Thomas Michel
Journal:  J Biol Chem       Date:  2005-03-17       Impact factor: 5.157

5.  Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission.

Authors:  H Wolosker; S Blackshaw; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

6.  D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor.

Authors:  J P Mothet; A T Parent; H Wolosker; R O Brady; D J Linden; C D Ferris; M A Rogawski; S H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2000-04-25       Impact factor: 11.205

7.  Serine racemase: activation by glutamate neurotransmission via glutamate receptor interacting protein and mediation of neuronal migration.

Authors:  Paul M Kim; Hiroyuki Aizawa; Peter S Kim; Alex S Huang; Sasrutha R Wickramasinghe; Amir H Kashani; Roxanne K Barrow; Richard L Huganir; Anirvan Ghosh; Solomon H Snyder
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-31       Impact factor: 11.205

8.  Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity.

Authors:  Veronika N Foltyn; Inna Bendikov; Joari De Miranda; Rogerio Panizzutti; Elena Dumin; Maria Shleper; Pu Li; Michael D Toney; Elena Kartvelishvily; Herman Wolosker
Journal:  J Biol Chem       Date:  2004-11-09       Impact factor: 5.157

Review 9.  Lessons from genetically engineered animal models. IV. Nitric oxide synthase gene knockout mice.

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Journal:  Am J Physiol       Date:  1999-10

10.  Neuron-derived D-serine release provides a novel means to activate N-methyl-D-aspartate receptors.

Authors:  Elena Kartvelishvily; Maria Shleper; Livia Balan; Elena Dumin; Herman Wolosker
Journal:  J Biol Chem       Date:  2006-03-21       Impact factor: 5.157
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  47 in total

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2.  Encoding of the cough reflex in anesthetized guinea pigs.

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Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2010-10-06       Impact factor: 3.619

Review 3.  Redox regulation of protein misfolding, mitochondrial dysfunction, synaptic damage, and cell death in neurodegenerative diseases.

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Journal:  Exp Neurol       Date:  2012-07-05       Impact factor: 5.330

4.  Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes.

Authors:  Masataka Suzuki; Jumpei Sasabe; Yurika Miyoshi; Kanako Kuwasako; Yutaka Muto; Kenji Hamase; Masaaki Matsuoka; Nobuaki Imanishi; Sadakazu Aiso
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-13       Impact factor: 11.205

Review 5.  Neuropathogenesis of HIV-1-associated neurocognitive disorders: a possible involvement of D-serine.

Authors:  Jianxun Xia; Huangui Xiong
Journal:  Int J Physiol Pathophysiol Pharmacol       Date:  2013-09-10

6.  In vivo D-serine hetero-exchange through alanine-serine-cysteine (ASC) transporters detected by microelectrode biosensors.

Authors:  Caroline Maucler; Pierre Pernot; Natalia Vasylieva; Loredano Pollegioni; Stéphane Marinesco
Journal:  ACS Chem Neurosci       Date:  2013-04-12       Impact factor: 4.418

7.  Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation.

Authors:  Karthik Raju; Paschalis-Thomas Doulias; Perry Evans; Elizabeth N Krizman; Joshua G Jackson; Oksana Horyn; Yevgeny Daikhin; Ilana Nissim; Marc Yudkoff; Itzhak Nissim; Kim A Sharp; Michael B Robinson; Harry Ischiropoulos
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Review 8.  Central regulation of the cough reflex: therapeutic implications.

Authors:  Brendan J Canning
Journal:  Pulm Pharmacol Ther       Date:  2009-01-20       Impact factor: 3.410

Review 9.  Aberrant protein s-nitrosylation in neurodegenerative diseases.

Authors:  Tomohiro Nakamura; Shichun Tu; Mohd Waseem Akhtar; Carmen R Sunico; Shu-Ichi Okamoto; Stuart A Lipton
Journal:  Neuron       Date:  2013-05-22       Impact factor: 17.173

10.  D-Serine metabolism in C6 glioma cells: Involvement of alanine-serine-cysteine transporter (ASCT2) and serine racemase (SRR) but not D-amino acid oxidase (DAO).

Authors:  Pilleriin Sikka; Rosie Walker; Rebecca Cockayne; Matthew J A Wood; Paul J Harrison; Philip W J Burnet
Journal:  J Neurosci Res       Date:  2010-06       Impact factor: 4.164
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