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Literature DB >> 2009935

4-aminopyridine and barium chloride attenuate the anti-epileptic effect of carbamazepine in hippocampal slices.

H Olpe¹, C N Kolb, A Hausdorf, H L Haas.

Abstract

The exact mode of action of the anti-epileptic agent carbamazepine is unknown. In hippocampal slices in which epileptiform discharges were induced by addition of penicillin to the perfusion medium, the depressant effect of carbamazepine was attenuated by the potassium-channel blockers barium chloride (0.1 mM) and 4-aminopyridine (200 microM), which suggested that potassium fluxes might be involved in the mechanism of action of carbamazepine.

Entities: Chemical Disease

Mesh：

Substances：

Year: 1991 PMID： 2009935 DOI： 10.1007/bf01958152

Source DB: PubMed Journal: Experientia ISSN： 0014-4754

10 in total

1. Comparison of the antimanic efficacy of carbamazepine and chlorpromazine: a double-blind controlled study.

Authors: T Okuma; K Inanaga; S Otsuki; K Sarai; R Takahashi; H Hazama; A Mori; M Watanabe
Journal: Psychopharmacology (Berl) Date: 1979 Impact factor: 4.530

2. Neuronal sensitivity to substance P is increased after repeated treatment with tranylcypromine, carbamazepine or oxaprotaline, but decreased after repeated electroconvulsive shock.

Authors: R S Jones; C Mondadori; H R Olpe
Journal: Neuropharmacology Date: 1985-07 Impact factor: 5.250

Review 3. The intrinsic electrophysiological properties of mammalian neurons: insights into central nervous system function.

Authors: R R Llinás
Journal: Science Date: 1988-12-23 Impact factor: 47.728

4. K+ channels openers prevent epilepsy induced by the bee venom peptide MCD.

Authors: G Gandolfo; C Gottesmann; J N Bidard; M Lazdunski
Journal: Eur J Pharmacol Date: 1989-01-17 Impact factor: 4.432

5. Electrophysiological and neurochemical investigations on the action of carbamazepine on the rat hippocampus.

Authors: H R Olpe; M Baudry; R S Jones
Journal: Eur J Pharmacol Date: 1985-03-26 Impact factor: 4.432

6. Analysis of carbamazepine actions in hippocampal slices of the rat.

Authors: T W Hood; J Siegfried; H L Haas
Journal: Cell Mol Neurobiol Date: 1983-09 Impact factor: 5.046

7. The action of piracetam on the electrical activity of the hippocampal slice preparation: a field potential analysis.

Authors: H R Olpe; G S Lynch
Journal: Eur J Pharmacol Date: 1982-06-04 Impact factor: 4.432

8. Penicillin-induced epileptiform activity in the hippocampal in vitro prepatation.

Authors: P A Schwartzkroin; D A Prince
Journal: Ann Neurol Date: 1977-05 Impact factor: 10.422

9. A purinergic component in the anticonvulsant action of carbamazepine?

Authors: J H Skeritt; L P Davies; G A Johnston
Journal: Eur J Pharmacol Date: 1982-08-27 Impact factor: 4.432

10. Carbamazepine and 10,11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture.

Authors: M J McLean; R L Macdonald
Journal: J Pharmacol Exp Ther Date: 1986-08 Impact factor: 4.030