Literature DB >> 1516682

Carbamazepine inhibits NMDA-induced depolarizations in cortical wedges prepared from DBA/2 mice.

J M Lancaster1, J A Davies.   

Abstract

There is some doubt as to the mechanism of action of the widely-used anticonvulsant drug, carbamazepine. In cortical wedges prepared from genetically epilepsy-prone DBA/2 mice, carbamazepine at therapeutic concentrations (1-10 microM) markedly reduced the depolarization produced by N-methyl-D-aspartate (NMDA). The NMDA sub-type of glutamate receptor has been implicated in the pathogenesis of epilepsy and the inhibitory action of carbamazepine on this response suggests that the anticonvulsant action of the drug may be due to its blockade of NMDA receptor-mediated events.

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Year:  1992        PMID： 1516682     DOI： 10.1007/bf02124294

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Comparison of the antimanic efficacy of carbamazepine and chlorpromazine: a double-blind controlled study.

Authors:  T Okuma; K Inanaga; S Otsuki; K Sarai; R Takahashi; H Hazama; A Mori; M Watanabe
Journal:  Psychopharmacology (Berl)       Date:  1979       Impact factor: 4.530

2.  4-aminopyridine and barium chloride attenuate the anti-epileptic effect of carbamazepine in hippocampal slices.

Authors:  H Olpe; C N Kolb; A Hausdorf; H L Haas
Journal:  Experientia       Date:  1991-03-15

3.  Desmethylimipramine potentiates NMDA responses in a mouse cortical slice preparation.

Authors:  J M Lancaster; J A Davies
Journal:  Neuroreport       Date:  1991-11       Impact factor: 1.837

4.  CSF concentrations and serum protein binding of carbamazepine and carbamazepine-10,11-epoxide in epileptic patients.

Authors:  S I Johannessen; M Gerna; J Bakke; R E Strandjord; P L Morselli
Journal:  Br J Clin Pharmacol       Date:  1976-08       Impact factor: 4.335

5.  Carbamazepine blocks NMDA-activated currents in cultured spinal cord neurons.

Authors:  H Lampe; H Bigalke
Journal:  Neuroreport       Date:  1990-09       Impact factor: 1.837

6.  NMDA antagonists differentiate epileptogenesis from seizure expression in an in vitro model.

Authors:  S F Stasheff; W W Anderson; S Clark; W A Wilson
Journal:  Science       Date:  1989-08-11       Impact factor: 47.728

7.  The mouse neocortical slice: preparation and responses to excitatory amino acids.

Authors:  N R Burton; D A Smith; T W Stone
Journal:  Comp Biochem Physiol C       Date:  1987

8.  Carbamazepine and 10,11-epoxycarbamazepine produce use- and voltage-dependent limitation of rapidly firing action potentials of mouse central neurons in cell culture.

Authors:  M J McLean; R L Macdonald
Journal:  J Pharmacol Exp Ther       Date:  1986-08       Impact factor: 4.030
  8 in total
  2 in total

Review 1.  Mechanisms of action of carbamazepine and its derivatives, oxcarbazepine, BIA 2-093, and BIA 2-024.

Authors:  António F Ambrósio; Patrício Soares-Da-Silva; Caetana M Carvalho; Arsélio P Carvalho
Journal:  Neurochem Res       Date:  2002-02       Impact factor: 3.996

2.  Chronic carbamazepine administration reduces N-methyl-D-aspartate receptor-initiated signaling via arachidonic acid in rat brain.

Authors:  Mireille Basselin; Nelly E Villacreses; Mei Chen; Jane M Bell; Stanley I Rapoport
Journal:  Biol Psychiatry       Date:  2007-07-12       Impact factor: 13.382
  2 in total

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