Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 A purinergic component in the anticonvulsant action of carbamazepine?

Literature DB >> 7128687

A purinergic component in the anticonvulsant action of carbamazepine?

Abstract

The tricyclic anticonvulsant carbamazepine inhibited the binding of [3H]phenylisopropyladenosine (PIA) to rat brain membranes with a K1 value of 44 microM, which is in the range of therapeutic levels of this drug in brain and serum. Other anticonvulsants and tricyclic antidepressants had little effect on PIA binding. Carbamazepine weakly inhibited adenosine uptake into rat brain slices at 400 microM. An effect on adenosine receptors may be an important component of the anticonvulsant action of carbamazepine.

Entities: Chemical Species

Mesh：

Substances：

Year: 1982 PMID： 7128687 DOI： 10.1016/0014-2999(82)90512-x

Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432

Keyword Cloud
Cited

11 in total

1. 4-aminopyridine and barium chloride attenuate the anti-epileptic effect of carbamazepine in hippocampal slices.

Authors: H Olpe; C N Kolb; A Hausdorf; H L Haas
Journal: Experientia Date: 1991-03-15

2. Purines and the Anti-Epileptic Actions of Ketogenic Diets.

Authors: Susan A Masino; Masahito Kawamura; David N Ruskin; Jeremy Gawryluk; Xuesong Chen; Jonathan D Geiger
Journal: Open Neurosci J Date: 2010-01-01

3. Differential effects of agents enhancing purinergic transmission upon the antielectroshock efficacy of carbamazepine, diphenylhydantoin, diazepam, phenobarbital, and valproate in mice.

Authors: S J Czuczwar; B Szczepanik; A Wamil; W Janusz; Z Kleinrok
Journal: J Neural Transm Gen Sect Date: 1990

4. Mood stabilizer psychopharmacology.

Authors: Todd D Gould; Guang Chen; Husseini K Manji
Journal: Clin Neurosci Res Date: 2002-11-14

5. Inhibition of agonist-stimulated inositol lipid metabolism by the anticonvulsant carbamazepine in rat hippocampus.

Authors: E E McDermott; S D Logan
Journal: Br J Pharmacol Date: 1989-10 Impact factor: 8.739

6. Influence of CGS 15943 A (a nonxanthine adenosine antagonist) on the protection offered by a variety of antiepileptic drugs against maximal electroshock-induced seizures in mice.

Authors: S J Czuczwar; W Janusz; B Szczepanik; Z Kleinrok
Journal: J Neural Transm Gen Sect Date: 1991

A purinergic component in the anticonvulsant action of carbamazepine?

1. 4-aminopyridine and barium chloride attenuate the anti-epileptic effect of carbamazepine in hippocampal slices.

2. Purines and the Anti-Epileptic Actions of Ketogenic Diets.

3. Differential effects of agents enhancing purinergic transmission upon the antielectroshock efficacy of carbamazepine, diphenylhydantoin, diazepam, phenobarbital, and valproate in mice.

4. Mood stabilizer psychopharmacology.

5. Inhibition of agonist-stimulated inositol lipid metabolism by the anticonvulsant carbamazepine in rat hippocampus.

6. Influence of CGS 15943 A (a nonxanthine adenosine antagonist) on the protection offered by a variety of antiepileptic drugs against maximal electroshock-induced seizures in mice.

7. Effects of carbamazepine and baclofen on 4-aminopyridine-induced epileptic activity in rat hippocampal slices.

Review 8. The use of carbamazepine in the treatment of schizophrenic and schizoaffective psychoses: a review.

9. Effects of carbamazepine on noradrenergic mechanisms in affectively ill patients.

10. Non-xanthine heterocycles: activity as antagonists of A1- and A2-adenosine receptors.