Literature DB >> 20095602

DNA methylation increases nucleosome compaction and rigidity.

John S Choy1, Sijie Wei, Ju Yeon Lee, Song Tan, Steven Chu, Tae-Hee Lee.   

Abstract

Cytosine methylation on CpG dinucleotides is an essential epigenetic modification in eukaryotes. How DNA methylation modulates nucleosome structure and dynamics has been a long-standing question. We implemented a single-molecule method to monitor the effects of DNA methylation on the structure and dynamics of mononucleosomes. Our studies show that DNA methylation induces a more compact and rigid nucleosome structure, providing a physical basis for how DNA methylation might contribute to regulating chromatin structure.

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Year:  2010        PMID： 20095602      PMCID： PMC4167393          DOI： 10.1021/ja910264z

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


  13 in total

1.  Preparation of nucleosome core particle from recombinant histones.

Authors:  K Luger; T J Rechsteiner; T J Richmond
Journal:  Methods Enzymol       Date:  1999       Impact factor: 1.600

Review 2.  DNA methylation patterns and epigenetic memory.

Authors:  Adrian Bird
Journal:  Genes Dev       Date:  2002-01-01       Impact factor: 11.361

Review 3.  Structure and dynamic behavior of nucleosomes.

Authors:  Karolin Luger
Journal:  Curr Opin Genet Dev       Date:  2003-04       Impact factor: 5.578

Review 4.  DNA methylation, nucleosome formation and positioning.

Authors:  Sari Pennings; James Allan; Colin S Davey
Journal:  Brief Funct Genomic Proteomic       Date:  2005-02

Review 5.  Genomic patterns of DNA methylation: targets and function of an epigenetic mark.

Authors:  Michael Weber; Dirk Schübeler
Journal:  Curr Opin Cell Biol       Date:  2007-04-26       Impact factor: 8.382

6.  Structural variability of nucleosomes detected by single-pair Förster resonance energy transfer: histone acetylation, sequence variation, and salt effects.

Authors:  Alex Gansen; Katalin Tóth; Nathalie Schwarz; Jörg Langowski
Journal:  J Phys Chem B       Date:  2009-03-05       Impact factor: 2.991

7.  Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex.

Authors:  X Nan; H H Ng; C A Johnson; C D Laherty; B M Turner; R N Eisenman; A Bird
Journal:  Nature       Date:  1998-05-28       Impact factor: 49.962

8.  Distribution of 5-methylcytosine in chromatin.

Authors:  A Razin; H Cedar
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205

Review 9.  Effects of DNA methylation on DNA-binding proteins and gene expression.

Authors:  P H Tate; A P Bird
Journal:  Curr Opin Genet Dev       Date:  1993-04       Impact factor: 5.578

10.  Organization of 5-methylcytosine in chromosomal DNA.

Authors:  A Solage; H Cedar
Journal:  Biochemistry       Date:  1978-07-11       Impact factor: 3.162
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  89 in total

1.  Effects of DNA methylation on the structure of nucleosomes.

Authors:  Ju Yeon Lee; Tae-Hee Lee
Journal:  J Am Chem Soc       Date:  2011-12-15       Impact factor: 15.419

2.  5'-Cytosine-phosphoguanine (CpG) methylation impacts the activity of natural and engineered meganucleases.

Authors:  Julien Valton; Fayza Daboussi; Sophie Leduc; Rafael Molina; Pilar Redondo; Rachel Macmaster; Guillermo Montoya; Philippe Duchateau
Journal:  J Biol Chem       Date:  2012-06-27       Impact factor: 5.157

3.  Chromatin density and splicing destiny: on the cross-talk between chromatin structure and splicing.

Authors:  Schraga Schwartz; Gil Ast
Journal:  EMBO J       Date:  2010-04-20       Impact factor: 11.598

4.  Ethnic diversity of DNA methylation in the OPRM1 promoter region in lymphocytes of heroin addicts.

Authors:  David A Nielsen; Sara Hamon; Vadim Yuferov; Colin Jackson; Ann Ho; Jurg Ott; Mary Jeanne Kreek
Journal:  Hum Genet       Date:  2010-03-18       Impact factor: 4.132

5.  A lattice model for transcription factor access to nucleosomal DNA.

Authors:  Vladimir B Teif; Ramona Ettig; Karsten Rippe
Journal:  Biophys J       Date:  2010-10-20       Impact factor: 4.033

6.  Maternal micronutrient supplementation suppresses T cell chemokine receptor expression and function in F1 mice.

Authors:  Colin Delaney; Mark Hoeltzel; Sanjay K Garg; Roscoe Warner; Kent Johnson; Raymond Yung
Journal:  J Nutr       Date:  2012-05-30       Impact factor: 4.798

7.  Etiology of Obesity Over the Life Span: Ecological and Genetic Highlights from Asian Countries.

Authors:  Pei Nee Chong; Christinal Pey Wen Teh; Bee Koon Poh; Mohd Ismail Noor
Journal:  Curr Obes Rep       Date:  2014-03

8.  A Conformational Switch in the Zinc Finger Protein Kaiso Mediates Differential Readout of Specific and Methylated DNA Sequences.

Authors:  Evgenia N Nikolova; Robyn L Stanfield; H Jane Dyson; Peter E Wright
Journal:  Biochemistry       Date:  2020-05-12       Impact factor: 3.162

Review 9.  Cross-talk between site-specific transcription factors and DNA methylation states.

Authors:  Adam Blattler; Peggy J Farnham
Journal:  J Biol Chem       Date:  2013-10-22       Impact factor: 5.157

10.  Effects of histone acetylation by Piccolo NuA4 on the structure of a nucleosome and the interactions between two nucleosomes.

Authors:  Ju Yeon Lee; Sijie Wei; Tae-Hee Lee
Journal:  J Biol Chem       Date:  2011-01-31       Impact factor: 5.157
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